IL-1 as a systemic modifier of B lymphopoiesis. Recombinant IL-1 alpha binds to stromal cells and sinusoid endothelium in bone marrow and perturbs precursor B cell dynamics
B lymphopoiesis in mouse bone marrow (BM) can be stimulated by circulating products derived from activated macrophages in the spleen. To examine whether IL-1 could mediate this effect, we have administered murine rIL-1 alpha in a range of doses, determining its effect on precursor B cells and its ca...
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| Veröffentlicht in: | The Journal of immunology (1950) 1996-04, Vol.156 (7), p.2376-2383 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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