Cytocompatibility Evaluation of Grafted IKVAV PLEOF Hydrogels with Bone Marrow Mesenchymal Stem Cells
The novel hydrogels-grafted IKVAV poly（lactide-co-ethylene oxide-co-fumarate）（PLEOF） hydrogels（GIPHs） were developed. The rat bone marrow mesenchymal stem cells（BMMSCs） were employed, and the cell vitality and apoptosis assays were carried out to evaluate the cytocomptibility of GIPHs. Our data demo...
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| Veröffentlicht in: | Journal of Wuhan University of Technology. Materials science edition 2014-08, Vol.29 (4), p.824-831 |
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| container_title | Journal of Wuhan University of Technology. Materials science edition |
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| creator | Li, Binbin Zhang, Ping Yin, Yixia Qiu, Tong Tao, Yuan Wang, Xinyu Li, Shipu |
| description | The novel hydrogels-grafted IKVAV poly（lactide-co-ethylene oxide-co-fumarate）（PLEOF） hydrogels（GIPHs） were developed. The rat bone marrow mesenchymal stem cells（BMMSCs） were employed, and the cell vitality and apoptosis assays were carried out to evaluate the cytocomptibility of GIPHs. Our data demonstrated that the infl uence of GIPHs on the proliferation of BMMSCs was in a concentration and time dependent manner. The proliferative ability of BMMSCs in GIPHs-treated group（100 μg/mL） after 72 h presented a maximum response which was 30.1% more than that of control group. The numbers of apoptotic cells in GIPHs-treated group（100 μg/mL） were just as much as that of control group after 24 h treatment. The GIPHs are able to provide an appropriate environment for BMMSCs survival and proliferation. |
| doi_str_mv | 10.1007/s11595-014-1004-6 |
| format | Article |
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The rat bone marrow mesenchymal stem cells（BMMSCs） were employed, and the cell vitality and apoptosis assays were carried out to evaluate the cytocomptibility of GIPHs. Our data demonstrated that the infl uence of GIPHs on the proliferation of BMMSCs was in a concentration and time dependent manner. The proliferative ability of BMMSCs in GIPHs-treated group（100 μg/mL） after 72 h presented a maximum response which was 30.1% more than that of control group. The numbers of apoptotic cells in GIPHs-treated group（100 μg/mL） were just as much as that of control group after 24 h treatment. 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The GIPHs are able to provide an appropriate environment for BMMSCs survival and proliferation.</description><subject>Apoptosis</subject><subject>Assaying</subject><subject>Biomaterials</subject><subject>Bone marrow</subject><subject>Chemistry and Materials Science</subject><subject>Grafting</subject><subject>Hydrogels</subject><subject>Materials Science</subject><subject>Stem cells</subject><subject>Survival</subject><subject>增殖能力</subject><subject>嫁接</subject><subject>时间依赖性</subject><subject>水凝胶</subject><subject>环氧乙烷</subject><subject>细胞相容性</subject><subject>评价</subject><subject>骨髓间充质干细胞</subject><issn>1000-2413</issn><issn>1993-0437</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp9kEtPwkAUhRujiYj-AHcT3bipznRedImEV4RgorJtpu0dKGk7OFMk_fcOgRjjwtW9J_nOfZwguCX4kWAsnxwhPOYhJiz0moXiLOiQOKYhZlSe-x5jHEaM0MvgyrmNRzAVohPAoG1MZqqtaoq0KIumRcMvVe68NDUyGo2t0g3kaPqy7C_R62y4GKFJm1uzgtKhfdGs0bOpAc2VtWaP5uCgztZtpUr01kCFBlCW7jq40Kp0cHOq3eBjNHwfTMLZYjwd9GdhRqVowkiICCTLNaSSpyAVyFxpIrlSeeQf7HECNCU6ixgTuRYyz6Ie4akErWKQknaDh-PcrTWfO3BNUhUu8xeoGszOJYQLSbCknHv0_g-6MTtb--s8xbFkNI6Yp8iRyqxxzoJOtraolG0TgpND8Mkx-MQHf9AsEd4THT3Os_UK7K_J_5juTovWpl59et_PJh8K4Yfv6Td0U5C-</recordid><startdate>20140801</startdate><enddate>20140801</enddate><creator>Li, Binbin</creator><creator>Zhang, Ping</creator><creator>Yin, Yixia</creator><creator>Qiu, Tong</creator><creator>Tao, Yuan</creator><creator>Wang, Xinyu</creator><creator>Li, Shipu</creator><general>Wuhan University of Technology</general><general>Springer Nature B.V</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W92</scope><scope>~WA</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8AO</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7U5</scope><scope>L7M</scope></search><sort><creationdate>20140801</creationdate><title>Cytocompatibility Evaluation of Grafted IKVAV PLEOF Hydrogels with Bone Marrow Mesenchymal Stem Cells</title><author>Li, Binbin ; 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Materials science edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Binbin</au><au>Zhang, Ping</au><au>Yin, Yixia</au><au>Qiu, Tong</au><au>Tao, Yuan</au><au>Wang, Xinyu</au><au>Li, Shipu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytocompatibility Evaluation of Grafted IKVAV PLEOF Hydrogels with Bone Marrow Mesenchymal Stem Cells</atitle><jtitle>Journal of Wuhan University of Technology. Materials science edition</jtitle><stitle>J. Wuhan Univ. Technol.-Mat. Sci. Edit</stitle><addtitle>Journal of Wuhan University of Technology. 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| ispartof | Journal of Wuhan University of Technology. Materials science edition, 2014-08, Vol.29 (4), p.824-831 |
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| subjects | Apoptosis Assaying Biomaterials Bone marrow Chemistry and Materials Science Grafting Hydrogels Materials Science Stem cells Survival 增殖能力 嫁接 时间依赖性 水凝胶 环氧乙烷 细胞相容性 评价 骨髓间充质干细胞 |
| title | Cytocompatibility Evaluation of Grafted IKVAV PLEOF Hydrogels with Bone Marrow Mesenchymal Stem Cells |
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