Oleanolic acid improves hepatic insulin resistance via antioxidant, hypolipidemic and anti-inflammatory effects

•Oleanolic acid (OA) improves hepatic insulin resistance in db/db mice.•OA inhibits mitochondrial oxidative stress via activation of Nrf2–GCLc signal.•OA suppresses hepatic lipid accumulation and inflammation. Insulin resistance is the hallmark of type 2 diabetes mellitus (T2DM), which is closely re...

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Veröffentlicht in:	Molecular and cellular endocrinology 2013-08, Vol.376 (1-2), p.70-80
Hauptverfasser:	Wang, Xin, Liu, Rui, Zhang, Wei, Zhang, Xiaodi, Liao, Nai, Wang, Zhao, Li, Wenli, Qin, Xujun, Hai, Chunxu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anti-inflammatory activity Anti-Inflammatory Agents, Non-Steroidal - pharmacology antioxidants Antioxidants - pharmacology biogenesis blood glucose Blood Glucose - metabolism blood serum body weight Body Weight - drug effects Cellular cholesterol Cytokines - antagonists & inhibitors Cytokines - biosynthesis Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - metabolism Dyslipidemia fasting free fatty acids Gluconeogenesis Glucose glutathione Hepatic insulin resistance high density lipoprotein Hypolipidemic Agents - pharmacology Inflammation Injections, Intraperitoneal Insulin Insulin - metabolism Insulin Resistance interleukin-1beta interleukin-6 lipid metabolism Lipid Metabolism - drug effects Liver Liver - drug effects Liver - metabolism low density lipoprotein Male Mice Mice, Transgenic Mitochondrial Turnover - drug effects Noise levels noninsulin-dependent diabetes mellitus Oleanolic acid Oleanolic Acid - pharmacology Organ Size - drug effects Reactive oxygen species Reactive Oxygen Species - antagonists & inhibitors Serums triacylglycerols tumor necrosis factor-alpha ultrastructure Weight reduction
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