Steroid hormone synthesis in mitochondria

Mitochondria are essential sites for steroid hormone biosynthesis. Mitochondria in the steroidogenic cells of the adrenal, gonad, placenta and brain contain the cholesterol side-chain cleavage enzyme, P450scc, and its two electron-transfer partners, ferredoxin reductase and ferredoxin. This enzyme s...

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Veröffentlicht in:	Molecular and cellular endocrinology 2013-10, Vol.379 (1-2), p.62-73
1. Verfasser:	Miller, Walter L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Adrenal Cortex Hormones - biosynthesis aldosterone Biological Transport - physiology biosynthesis brain Cholesterol Cholesterol - metabolism Cholesterol side chain cleavage Cholesterol Side-Chain Cleavage Enzyme - metabolism Cholesterol transport Cyclic AMP-Dependent Protein Kinase Catalytic Subunits - metabolism deficiency diseases electron transfer Enzymes Gonadal Steroid Hormones - biosynthesis Hormones Humans imports Kinases Membrane Proteins - metabolism Mitochondria Mitochondria - enzymology Mitochondria - metabolism mitochondrial membrane Mitochondrial Membranes - enzymology Mitochondrial Membranes - metabolism Outer mitochondrial membrane Phosphoproteins - metabolism placenta Placental Hormones - biosynthesis pregnenolone Pregnenolone - biosynthesis Proteins Receptors, GABA - metabolism Regulators steroid hormones Steroidogenesis Steroidogenic acute regulatory protein Steroids Vitamin D Vitamin D - metabolism Voltage-Dependent Anion Channel 1 - metabolism
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