Industrial R&D on Catalytic CC and CN Coupling Reactions: A Personal Account on Goals, Approaches and Results

R&D issues for the application of Pd‐ and Ni‐catalyzed CC and CN coupling reactions in the fine chemicals industry are discussed. In a first part, some background is given on industrial R&D and the role of CC and CN coupling for preparative applications is described. The following princi...

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Veröffentlicht in:Advanced synthesis & catalysis 2004-12, Vol.346 (13-15), p.1583-1598
Hauptverfasser: Blaser, Hans-Ulrich, Indolese, Adriano, Naud, Frédéric, Nettekoven, Ulrike, Schnyder, Anita
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Sprache:eng
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Zusammenfassung:R&D issues for the application of Pd‐ and Ni‐catalyzed CC and CN coupling reactions in the fine chemicals industry are discussed. In a first part, some background is given on industrial R&D and the role of CC and CN coupling for preparative applications is described. The following principal approaches to industrial research are illustrated with relevant examples from the literature and from our own laboratories: i) development of catalysts and catalytic methodologies with industrial potential; ii) finding shorter routes to target molecules using catalytic methods; iii) development of industrial catalytic processes in multi‐step syntheses.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.200404156