Caloric restriction mimetics: towards a molecular definition

Caloric restriction can promote health and extend the lifespan of model organisms, and diverse classes of compounds that mimic the biochemical and functional effects of caloric restriction have attracted considerable interest as potential pharmacotherapies for diseases such as diabetes and obesity....

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Veröffentlicht in:	Nature reviews. Drug discovery 2014-10, Vol.13 (10), p.727-740
Hauptverfasser:	Madeo, Frank, Pietrocola, Federico, Eisenberg, Tobias, Kroemer, Guido
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/555 631/337/458/1275 631/80/39 692/699/2743/2037 Acetyl Coenzyme A - metabolism Acetylation - drug effects Acetyltransferases - antagonists & inhibitors Animals Autophagy - drug effects Biomedicine Biotechnology Caloric Restriction - methods Cancer Research Drug Design Drug therapy Humans Innovations Medicinal Chemistry Metabolic diseases Molecular Medicine Molecular targeted therapy opinion-2 Pharmacology, Experimental Pharmacology/Toxicology Weight reducing preparations
Online-Zugang:	Volltext
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