Moonlighting cell-surface GAPDH recruits apotransferrin to effect iron egress from mammalian cells

Iron (Fe(2+), Fe(3+)) homeostasis is a tightly regulated process, involving precise control of iron influx and egress from cells. Although the mechanisms of its import into cells by iron carrier molecules are well characterized, iron export remains poorly understood. The current paradigm envisages u...

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Veröffentlicht in:	Journal of cell science 2014-10, Vol.127 (Pt 19), p.4279-4291
Hauptverfasser:	Sheokand, Navdeep, Malhotra, Himanshu, Kumar, Santosh, Tillu, Vikas A, Chauhan, Anoop S, Raje, Chaaya I, Raje, Manoj
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoproteins - metabolism Ferric Compounds - metabolism Ferrous Compounds - metabolism Glyceraldehyde-3-Phosphate Dehydrogenases - metabolism Humans Rabbits Rats Rats, Sprague-Dawley Transferrin - metabolism
Online-Zugang:	Volltext
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