Discovery and characterization of a disulfide-locked C(2)-symmetric defensin peptide

We report the discovery of HD5-CD, an unprecedented C2-symmetric β-barrel-like covalent dimer of the cysteine-rich host-defense peptide human defensin 5 (HD5). Dimerization results from intermonomer disulfide exchange between the canonical α-defensin Cys(II)-Cys(IV) (Cys(5)-Cys(20)) bonds located at...

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Veröffentlicht in:	Journal of the American Chemical Society 2014-10, Vol.136 (39), p.13494-13497
Hauptverfasser:	Wommack, Andrew J, Ziarek, Joshua J, Tomaras, Jill, Chileveru, Haritha R, Zhang, Yunfei, Wagner, Gerhard, Nolan, Elizabeth M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinetobacter baumannii - drug effects alpha-Defensins - chemical synthesis alpha-Defensins - chemistry alpha-Defensins - metabolism Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Dimerization Disulfides - chemistry Humans Models, Molecular Structure-Activity Relationship
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