An Efficient Synthetic Method and Theoretical Calculations of Olmesartan Methyl Ether: Study of Biological Function of AT1 Antagonism

The dissolution of the antihypertensive AT1 antagonist olmesartan in methanol generates in situ a new highly bioactive methyl ether analogue via S N 1 mechanism involving an intramolecular proton transfer from carboxyl to hydroxyl group. Theoretical calculations confirmed the thermodynamic control p...

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Veröffentlicht in:	Combinatorial chemistry & high throughput screening 2014-01, Vol.17 (8), p.652-662
Hauptverfasser:	Ntountaniotis, Dimitrios, Agelis, George, Resvani, Amalia, Halabalaki, Maria, Liapakis, George, Spyridaki, Katerina, Grdadolnik, Simona Golic, Merzel, Franci, Kostidis, Sarantos, Potamitis, Constantinos, Tselios, Theodore, Matsoukas, John, Skaltsounis, Leandros Alexios, Mavromoustakos, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin Receptor Antagonists - chemical synthesis Angiotensin Receptor Antagonists - chemistry Antihypertensive Agents - chemical synthesis Antihypertensive Agents - chemistry Imidazoles - chemical synthesis Imidazoles - chemistry Models, Theoretical Molecular Structure Tetrazoles - chemical synthesis Tetrazoles - chemistry
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