Different associations of apoE gene polymorphism with metabolic syndrome in the Vojvodina Province (Serbia)
The metabolic syndrome (MetS) is a polygenic multifactorial metabolic disorder with strong socioeconomic influence. MetS has became a worldwide epidemic, that directly increases the risk of cardiovascular diseases and type 2 diabetes mellitus. The human apoE gene, coding Apolipoprotein E, has three...
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| Veröffentlicht in: | Molecular biology reports 2014-08, Vol.41 (8), p.5221-5227 |
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| description | The metabolic syndrome (MetS) is a polygenic multifactorial metabolic disorder with strong socioeconomic influence. MetS has became a worldwide epidemic, that directly increases the risk of cardiovascular diseases and type 2 diabetes mellitus. The human apoE gene, coding Apolipoprotein E, has three common polymorphisms in human population: e2, e3 and e4, which are proved to be associated with impaired lipid metabolism. The contribution of apoE polymorphism to MetS disorders has not been investigated previously in Vojvodina Province, region with the highest number of obese people in Serbia. The aim of this study was to evaluate apoE gene polymorphism in relation to MetS disorders. The healthy control group of 30 individuals and 63 MetS patients were examined for apoE variants in relation to biochemical and anthropometric parameters. The genotypes were determined by PCR–RFLP. Regarding all parameters, significantly higher values were detected in MetS group compared to control. The MetS group of patients had significantly higher frequency of e4 allele. In addition, positive relation was revealed between e4 allele presence and all measured parameters. It was found that the e4 allele was related with a significantly increased OR of MetS disorders according to the International Diabetes Federation definition. These results suggested that e4 allele may act as a one of determinants for development of metabolic syndrome. |
| doi_str_mv | 10.1007/s11033-014-3390-4 |
| format | Article |
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MetS has became a worldwide epidemic, that directly increases the risk of cardiovascular diseases and type 2 diabetes mellitus. The human apoE gene, coding Apolipoprotein E, has three common polymorphisms in human population: e2, e3 and e4, which are proved to be associated with impaired lipid metabolism. The contribution of apoE polymorphism to MetS disorders has not been investigated previously in Vojvodina Province, region with the highest number of obese people in Serbia. The aim of this study was to evaluate apoE gene polymorphism in relation to MetS disorders. The healthy control group of 30 individuals and 63 MetS patients were examined for apoE variants in relation to biochemical and anthropometric parameters. The genotypes were determined by PCR–RFLP. Regarding all parameters, significantly higher values were detected in MetS group compared to control. The MetS group of patients had significantly higher frequency of e4 allele. In addition, positive relation was revealed between e4 allele presence and all measured parameters. It was found that the e4 allele was related with a significantly increased OR of MetS disorders according to the International Diabetes Federation definition. These results suggested that e4 allele may act as a one of determinants for development of metabolic syndrome.</description><identifier>ISSN: 0301-4851</identifier><identifier>EISSN: 1573-4978</identifier><identifier>DOI: 10.1007/s11033-014-3390-4</identifier><identifier>PMID: 24879316</identifier><language>eng</language><publisher>Dordrecht: Springer-Verlag</publisher><subject>Adult ; Aged ; Alleles ; Animal Anatomy ; Animal Biochemistry ; apolipoprotein E ; Apolipoproteins E - genetics ; Biomedical and Life Sciences ; Blood Glucose - metabolism ; Body Mass Index ; cardiovascular diseases ; Case-Control Studies ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Female ; genetic polymorphism ; Genetics ; Genotype ; Genotyping Techniques ; Histology ; human population ; Humans ; Life Sciences ; Lipid Metabolism ; Male ; Metabolic syndrome ; Metabolic Syndrome - genetics ; Middle Aged ; Molecular biology ; Morphology ; noninsulin-dependent diabetes mellitus ; patients ; people ; Polymorphism ; Polymorphism, Genetic ; risk ; Serbia ; Triglycerides - blood ; Waist Circumference ; Young Adult ; Yugoslavia</subject><ispartof>Molecular biology reports, 2014-08, Vol.41 (8), p.5221-5227</ispartof><rights>Springer Science+Business Media Dordrecht 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-26a2fe5104353a31ea562ce343864858f4bb0f48f2520e0047d0f0956b7c0fa63</citedby><cites>FETCH-LOGICAL-c462t-26a2fe5104353a31ea562ce343864858f4bb0f48f2520e0047d0f0956b7c0fa63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11033-014-3390-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11033-014-3390-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27933,27934,41497,42566,51328</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24879316$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vučinić, Nataša</creatorcontrib><creatorcontrib>Djan, Igor</creatorcontrib><creatorcontrib>Stokić, Edita</creatorcontrib><creatorcontrib>Božin, Biljana</creatorcontrib><creatorcontrib>Obreht, Dragana</creatorcontrib><creatorcontrib>Stankov, Karmen</creatorcontrib><creatorcontrib>Djan, Mihajla</creatorcontrib><title>Different associations of apoE gene polymorphism with metabolic syndrome in the Vojvodina Province (Serbia)</title><title>Molecular biology reports</title><addtitle>Mol Biol Rep</addtitle><addtitle>Mol Biol Rep</addtitle><description>The metabolic syndrome (MetS) is a polygenic multifactorial metabolic disorder with strong socioeconomic influence. MetS has became a worldwide epidemic, that directly increases the risk of cardiovascular diseases and type 2 diabetes mellitus. The human apoE gene, coding Apolipoprotein E, has three common polymorphisms in human population: e2, e3 and e4, which are proved to be associated with impaired lipid metabolism. The contribution of apoE polymorphism to MetS disorders has not been investigated previously in Vojvodina Province, region with the highest number of obese people in Serbia. The aim of this study was to evaluate apoE gene polymorphism in relation to MetS disorders. The healthy control group of 30 individuals and 63 MetS patients were examined for apoE variants in relation to biochemical and anthropometric parameters. The genotypes were determined by PCR–RFLP. Regarding all parameters, significantly higher values were detected in MetS group compared to control. The MetS group of patients had significantly higher frequency of e4 allele. In addition, positive relation was revealed between e4 allele presence and all measured parameters. It was found that the e4 allele was related with a significantly increased OR of MetS disorders according to the International Diabetes Federation definition. These results suggested that e4 allele may act as a one of determinants for development of metabolic syndrome.</description><subject>Adult</subject><subject>Aged</subject><subject>Alleles</subject><subject>Animal Anatomy</subject><subject>Animal Biochemistry</subject><subject>apolipoprotein E</subject><subject>Apolipoproteins E - genetics</subject><subject>Biomedical and Life Sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Body Mass Index</subject><subject>cardiovascular diseases</subject><subject>Case-Control Studies</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Female</subject><subject>genetic polymorphism</subject><subject>Genetics</subject><subject>Genotype</subject><subject>Genotyping Techniques</subject><subject>Histology</subject><subject>human population</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Lipid Metabolism</subject><subject>Male</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - genetics</subject><subject>Middle Aged</subject><subject>Molecular biology</subject><subject>Morphology</subject><subject>noninsulin-dependent diabetes mellitus</subject><subject>patients</subject><subject>people</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>risk</subject><subject>Serbia</subject><subject>Triglycerides - blood</subject><subject>Waist Circumference</subject><subject>Young Adult</subject><subject>Yugoslavia</subject><issn>0301-4851</issn><issn>1573-4978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkU1v1DAURS1ERYfCD2ADltiUReA5_sosUVugUqUilbK1nMzzjIfETu1Mq_n3uKQg1AVi5YXPvfbVIeQVg_cMQH_IjAHnFTBRcb6ESjwhCyY1r8RSN0_JAjiwSjSSHZLnOW8BQDAtn5HDWjR6yZlakB-n3jlMGCZqc46dt5OPIdPoqB3jGV1jQDrGfj_ENG58HuidnzZ0wMm2sfcdzfuwSnFA6gOdNki_x-1tXPlg6dcUb33okB5fYWq9ffeCHDjbZ3z5cB6R609n306-VBeXn89PPl5UnVD1VNXK1g4lA8Elt5yhlarukAveqDKmcaJtwYnG1bIGLJv0ChwspWp1B84qfkSO594xxZsd5skMPnfY9zZg3GXDpFKN5Err_0BFo3ijGSvo20foNu5SKEN-UUyr8sFCsZnqUsw5oTNj8oNNe8PA3EszszRTpJl7aUaUzOuH5l074OpP4relAtQzkMtVWGP66-l_tL6ZQ85GY9fJZ3N9VRcAgBVCAP8JVrqpnA</recordid><startdate>20140801</startdate><enddate>20140801</enddate><creator>Vučinić, Nataša</creator><creator>Djan, Igor</creator><creator>Stokić, Edita</creator><creator>Božin, Biljana</creator><creator>Obreht, Dragana</creator><creator>Stankov, Karmen</creator><creator>Djan, Mihajla</creator><general>Springer-Verlag</general><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20140801</creationdate><title>Different associations of apoE gene polymorphism with metabolic syndrome in the Vojvodina Province (Serbia)</title><author>Vučinić, Nataša ; Djan, Igor ; Stokić, Edita ; Božin, Biljana ; Obreht, Dragana ; Stankov, Karmen ; Djan, Mihajla</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-26a2fe5104353a31ea562ce343864858f4bb0f48f2520e0047d0f0956b7c0fa63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alleles</topic><topic>Animal Anatomy</topic><topic>Animal Biochemistry</topic><topic>apolipoprotein E</topic><topic>Apolipoproteins E - genetics</topic><topic>Biomedical and Life Sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Body Mass Index</topic><topic>cardiovascular diseases</topic><topic>Case-Control Studies</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Female</topic><topic>genetic polymorphism</topic><topic>Genetics</topic><topic>Genotype</topic><topic>Genotyping Techniques</topic><topic>Histology</topic><topic>human population</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Lipid Metabolism</topic><topic>Male</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - genetics</topic><topic>Middle Aged</topic><topic>Molecular biology</topic><topic>Morphology</topic><topic>noninsulin-dependent diabetes mellitus</topic><topic>patients</topic><topic>people</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>risk</topic><topic>Serbia</topic><topic>Triglycerides - blood</topic><topic>Waist Circumference</topic><topic>Young Adult</topic><topic>Yugoslavia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vučinić, Nataša</creatorcontrib><creatorcontrib>Djan, Igor</creatorcontrib><creatorcontrib>Stokić, Edita</creatorcontrib><creatorcontrib>Božin, Biljana</creatorcontrib><creatorcontrib>Obreht, Dragana</creatorcontrib><creatorcontrib>Stankov, Karmen</creatorcontrib><creatorcontrib>Djan, Mihajla</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular biology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vučinić, Nataša</au><au>Djan, Igor</au><au>Stokić, Edita</au><au>Božin, Biljana</au><au>Obreht, Dragana</au><au>Stankov, Karmen</au><au>Djan, Mihajla</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Different associations of apoE gene polymorphism with metabolic syndrome in the Vojvodina Province (Serbia)</atitle><jtitle>Molecular biology reports</jtitle><stitle>Mol Biol Rep</stitle><addtitle>Mol Biol Rep</addtitle><date>2014-08-01</date><risdate>2014</risdate><volume>41</volume><issue>8</issue><spage>5221</spage><epage>5227</epage><pages>5221-5227</pages><issn>0301-4851</issn><eissn>1573-4978</eissn><abstract>The metabolic syndrome (MetS) is a polygenic multifactorial metabolic disorder with strong socioeconomic influence. MetS has became a worldwide epidemic, that directly increases the risk of cardiovascular diseases and type 2 diabetes mellitus. The human apoE gene, coding Apolipoprotein E, has three common polymorphisms in human population: e2, e3 and e4, which are proved to be associated with impaired lipid metabolism. The contribution of apoE polymorphism to MetS disorders has not been investigated previously in Vojvodina Province, region with the highest number of obese people in Serbia. The aim of this study was to evaluate apoE gene polymorphism in relation to MetS disorders. The healthy control group of 30 individuals and 63 MetS patients were examined for apoE variants in relation to biochemical and anthropometric parameters. The genotypes were determined by PCR–RFLP. Regarding all parameters, significantly higher values were detected in MetS group compared to control. The MetS group of patients had significantly higher frequency of e4 allele. In addition, positive relation was revealed between e4 allele presence and all measured parameters. It was found that the e4 allele was related with a significantly increased OR of MetS disorders according to the International Diabetes Federation definition. These results suggested that e4 allele may act as a one of determinants for development of metabolic syndrome.</abstract><cop>Dordrecht</cop><pub>Springer-Verlag</pub><pmid>24879316</pmid><doi>10.1007/s11033-014-3390-4</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Alleles Animal Anatomy Animal Biochemistry apolipoprotein E Apolipoproteins E - genetics Biomedical and Life Sciences Blood Glucose - metabolism Body Mass Index cardiovascular diseases Case-Control Studies Cholesterol, HDL - blood Cholesterol, LDL - blood Female genetic polymorphism Genetics Genotype Genotyping Techniques Histology human population Humans Life Sciences Lipid Metabolism Male Metabolic syndrome Metabolic Syndrome - genetics Middle Aged Molecular biology Morphology noninsulin-dependent diabetes mellitus patients people Polymorphism Polymorphism, Genetic risk Serbia Triglycerides - blood Waist Circumference Young Adult Yugoslavia |
| title | Different associations of apoE gene polymorphism with metabolic syndrome in the Vojvodina Province (Serbia) |
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