ABCA12 Regulates ABCA1-Dependent Cholesterol Efflux from Macrophages and the Development of Atherosclerosis

ABCA12 is involved in the transport of ceramides in skin, but it may play a wider role in lipid metabolism. We show that, in Abca12-deficient macrophages, cholesterol efflux failed to respond to activation with LXR agonists. Abca12 deficiency caused a reduction in the abundance of Abca1, Abcg1, and...

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Veröffentlicht in:	Cell metabolism 2013-08, Vol.18 (2), p.225-238
Hauptverfasser:	Fu, Ying, Mukhamedova, Nigora, Ip, Sally, D’Souza, Wilissa, Henley, Katya J., DiTommaso, Tia, Kesani, Rajitha, Ditiatkovski, Michael, Jones, Lynelle, Lane, Rachael M., Jennings, Garry, Smyth, Ian M., Kile, Benjamin T., Sviridov, Dmitri
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atherosclerosis - genetics Atherosclerosis - metabolism ATP Binding Cassette Transporter 1 - metabolism ATP Binding Cassette Transporter, Sub-Family G, Member 1 ATP-Binding Cassette Transporters - deficiency ATP-Binding Cassette Transporters - metabolism Biological Transport - genetics Cell Line Cholesterol - metabolism Foam Cells - metabolism HeLa Cells Humans Lipid Metabolism - genetics Lipoproteins - metabolism Liver X Receptors Macrophages - metabolism Mice Mice, Inbred C57BL Mice, Transgenic Orphan Nuclear Receptors - biosynthesis Orphan Nuclear Receptors - metabolism
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