The MAP1B case: An old MAP that is new again
ABSTRACT The functions of microtubule‐associated protein 1B (MAP1B) have historically been linked to the development of the nervous system, based on its very early expression in neurons and glial cells. Moreover, mice in which MAP1B is genetically inactivated have been used extensively to show its r...
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| Veröffentlicht in: | Developmental neurobiology (Hoboken, N.J.) N.J.), 2014-10, Vol.74 (10), p.953-971 |
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| container_title | Developmental neurobiology (Hoboken, N.J.) |
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| creator | Villarroel‐Campos, David Gonzalez‐Billault, Christian |
| description | ABSTRACT
The functions of microtubule‐associated protein 1B (MAP1B) have historically been linked to the development of the nervous system, based on its very early expression in neurons and glial cells. Moreover, mice in which MAP1B is genetically inactivated have been used extensively to show its role in axonal elongation, neuronal migration, and axonal guidance. In the last few years, it has become apparent that MAP1B has other cellular and molecular functions that are not related to its microtubule‐stabilizing properties in the embryonic and adult brain. In this review, we present a systematic review of the canonical and novel functions of MAP1B and propose that, in addition to regulating the polymerization of microtubule and actin microfilaments, MAP1B also acts as a signaling protein involved in normal physiology and pathological conditions in the nervous system. © 2014 Wiley Periodicals, Inc. Develop Neurobiol 74: 953–971, 2014 |
| doi_str_mv | 10.1002/dneu.22178 |
| format | Article |
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The functions of microtubule‐associated protein 1B (MAP1B) have historically been linked to the development of the nervous system, based on its very early expression in neurons and glial cells. Moreover, mice in which MAP1B is genetically inactivated have been used extensively to show its role in axonal elongation, neuronal migration, and axonal guidance. In the last few years, it has become apparent that MAP1B has other cellular and molecular functions that are not related to its microtubule‐stabilizing properties in the embryonic and adult brain. In this review, we present a systematic review of the canonical and novel functions of MAP1B and propose that, in addition to regulating the polymerization of microtubule and actin microfilaments, MAP1B also acts as a signaling protein involved in normal physiology and pathological conditions in the nervous system. © 2014 Wiley Periodicals, Inc. Develop Neurobiol 74: 953–971, 2014</description><subject>Animals</subject><subject>Brain - metabolism</subject><subject>cytoskeleton</subject><subject>FMRP</subject><subject>Humans</subject><subject>Microtubule-Associated Proteins - metabolism</subject><subject>Myasthenia Gravis</subject><subject>neuronal differentiation</subject><subject>neuronal signaling</subject><subject>Neurons - metabolism</subject><subject>neurotransmitter receptors</subject><issn>1932-8451</issn><issn>1932-846X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0E1Lw0AQBuBFFFurF3-ABLyI2Lqz2d1svNVaP6B-HFrwFjazW5uSJjXbUPrvTZrqwYN4mmF4eGFeQk6B9oBSdm0yW_YYg0DtkTaEPusqLt_3f3YBLXLk3JxS4TNJD0mL8YBSScM2uRrPrPfcf4NbD7WzN14_8_LU1CdvNdMrL3FeZtee_tBJdkwOpjp19mQ3O2RyPxwPHruj14enQX_URS6p6mJghGYoOQLqwMdpgDGAD7EKpcE4NAKZNiFHbTmaqQKIDSqFKuDocx76HXLR5C6L_LO0bhUtEoc2TXVm89JFIKRUggru_4dCKMMAREXPf9F5XhZZ9chWMcECv1aXjcIid66w02hZJAtdbCKgUV13VNcdbeuu8NkusowX1vzQ734rAA1YJ6nd_BEV3b0MJ03oF-TChhM</recordid><startdate>201410</startdate><enddate>201410</enddate><creator>Villarroel‐Campos, David</creator><creator>Gonzalez‐Billault, Christian</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201410</creationdate><title>The MAP1B case: An old MAP that is new again</title><author>Villarroel‐Campos, David ; Gonzalez‐Billault, Christian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4608-c7d5a2c64c1ca73cf7cb1131b896dcb9d5c2ad94cae4cdf811bdc88c874c34493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Brain - metabolism</topic><topic>cytoskeleton</topic><topic>FMRP</topic><topic>Humans</topic><topic>Microtubule-Associated Proteins - metabolism</topic><topic>Myasthenia Gravis</topic><topic>neuronal differentiation</topic><topic>neuronal signaling</topic><topic>Neurons - metabolism</topic><topic>neurotransmitter receptors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Villarroel‐Campos, David</creatorcontrib><creatorcontrib>Gonzalez‐Billault, Christian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental neurobiology (Hoboken, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Villarroel‐Campos, David</au><au>Gonzalez‐Billault, Christian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The MAP1B case: An old MAP that is new again</atitle><jtitle>Developmental neurobiology (Hoboken, N.J.)</jtitle><addtitle>Dev Neurobiol</addtitle><date>2014-10</date><risdate>2014</risdate><volume>74</volume><issue>10</issue><spage>953</spage><epage>971</epage><pages>953-971</pages><issn>1932-8451</issn><eissn>1932-846X</eissn><abstract>ABSTRACT
The functions of microtubule‐associated protein 1B (MAP1B) have historically been linked to the development of the nervous system, based on its very early expression in neurons and glial cells. Moreover, mice in which MAP1B is genetically inactivated have been used extensively to show its role in axonal elongation, neuronal migration, and axonal guidance. In the last few years, it has become apparent that MAP1B has other cellular and molecular functions that are not related to its microtubule‐stabilizing properties in the embryonic and adult brain. In this review, we present a systematic review of the canonical and novel functions of MAP1B and propose that, in addition to regulating the polymerization of microtubule and actin microfilaments, MAP1B also acts as a signaling protein involved in normal physiology and pathological conditions in the nervous system. © 2014 Wiley Periodicals, Inc. Develop Neurobiol 74: 953–971, 2014</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>24700609</pmid><doi>10.1002/dneu.22178</doi><tpages>19</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Free Content; EZB-FREE-00999 freely available EZB journals; Wiley Online Library All Journals |
| subjects | Animals Brain - metabolism cytoskeleton FMRP Humans Microtubule-Associated Proteins - metabolism Myasthenia Gravis neuronal differentiation neuronal signaling Neurons - metabolism neurotransmitter receptors |
| title | The MAP1B case: An old MAP that is new again |
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