Exhaled Nitric Oxide Predicts Eosinophilic Airway Inflammation in COPD
Purpose Chronic obstructive pulmonary disease (COPD) with eosinophilic airway inflammation may represent a unique phenotype, possibly with shared features of COPD and asthma. The role of exhaled nitric oxide (eNO) in identifying COPD patients with sputum eosinophilia was examined in this study. Meth...
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| Veröffentlicht in: | Lung 2014-08, Vol.192 (4), p.499-504 |
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| creator | Chou, Kun-Ta Su, Kang-Cheng Huang, Shiang-Fen Hsiao, Yi-Han Tseng, Ching-Min Su, Vincent Yi-Fong Hung, Shih-Chieh Perng, Diahn-Warng |
| description | Purpose
Chronic obstructive pulmonary disease (COPD) with eosinophilic airway inflammation may represent a unique phenotype, possibly with shared features of COPD and asthma. The role of exhaled nitric oxide (eNO) in identifying COPD patients with sputum eosinophilia was examined in this study.
Methods
Ninety COPD patients without past medical history of asthma or allergic diseases were prospectively enrolled, and their eNO, lung function, and cellular profile of induced sputum were measured. Eosinophil cationic protein and IgE in sputum and venous blood also were determined. Subjects with and without sputum eosinophilia (>3 %) were compared. The role of eNO in the prediction of sputum eosinophilia was assessed in a logistic regression model.
Results
Patients with sputum eosinophilia had significantly higher levels of eNO (29 vs. 18 ppb,
p
= 0.01) than those without. The difference in serum total IgE (168 vs. 84.9 IU/ml,
p
= 0.057) and percentages of positive allergen test results (48.3 vs. 29.5 %,
p
= 0.082) showed a trend toward significance. The sputum eosinophil level was significantly correlated to the eNO level (
r
= 0.485,
p
23.5 ppb) in the prediction of sputum eosinophilia were 3.909 (confidence interval (CI) 1.542–9.91,
p
= 0.004) and 4.329 (CI 1.306–14.356,
p
= 0.017), respectively.
Conclusions
eNO is a good marker to identify COPD patients with eosinophilic airway inflammation. |
| doi_str_mv | 10.1007/s00408-014-9591-8 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1566850431</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A383575729</galeid><sourcerecordid>A383575729</sourcerecordid><originalsourceid>FETCH-LOGICAL-c747t-c6efc97c0398015411fef9001bdb96e41c9d30efe0d59b4a437b7ae0d860f2823</originalsourceid><addsrcrecordid>eNqNkl9v0zAUxSMEYmXwAXhBkZAQLxnXseM_j1XpYNJE9wDPluvYrafELnaibd8eVx2QoTJNfrBs_865V76nKN4iOEMA7FMCIMArQKQSjUAVf1bMEMF1hVgDz4sZYIKqOjMnxauUrgEQo6h5WZzUhCMqKJsV58vbrepMW35zQ3S6XN261pRX0bROD6lchuR82G1dl9_mLt6ou_LC2071vRpc8KXz5WJ19fl18cKqLpk39_tp8eN8-X3xtbpcfblYzC8rzQgbKk2N1YJpwIIDaghC1liR-1q3a0ENQVq0GIw10DZiTRTBbM1UPnEKtuY1Pi0-Hnx3MfwcTRpk75I2Xae8CWOSqKGUN0Awyuj7f9DrMEafu8sUocC4EPCX2uRfkM7bMESl96ZyTjAGwkhNH6Uwxw1rWC0yVR2hNsabqLrgjXX5-oHrU_ip_9kRPq_W9E4fLfAkwbTCh4lga1Q3bFPoxv2o00PnR8GpIzqAOoaUorFyF12v4p1EIPchlocQyxxiuQ-x5Fnz7n5y47o37R_F79RmoD4AKT_5jYmT0f7X9RfPYPSL</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1546078990</pqid></control><display><type>article</type><title>Exhaled Nitric Oxide Predicts Eosinophilic Airway Inflammation in COPD</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Chou, Kun-Ta ; Su, Kang-Cheng ; Huang, Shiang-Fen ; Hsiao, Yi-Han ; Tseng, Ching-Min ; Su, Vincent Yi-Fong ; Hung, Shih-Chieh ; Perng, Diahn-Warng</creator><creatorcontrib>Chou, Kun-Ta ; Su, Kang-Cheng ; Huang, Shiang-Fen ; Hsiao, Yi-Han ; Tseng, Ching-Min ; Su, Vincent Yi-Fong ; Hung, Shih-Chieh ; Perng, Diahn-Warng</creatorcontrib><description>Purpose
Chronic obstructive pulmonary disease (COPD) with eosinophilic airway inflammation may represent a unique phenotype, possibly with shared features of COPD and asthma. The role of exhaled nitric oxide (eNO) in identifying COPD patients with sputum eosinophilia was examined in this study.
Methods
Ninety COPD patients without past medical history of asthma or allergic diseases were prospectively enrolled, and their eNO, lung function, and cellular profile of induced sputum were measured. Eosinophil cationic protein and IgE in sputum and venous blood also were determined. Subjects with and without sputum eosinophilia (>3 %) were compared. The role of eNO in the prediction of sputum eosinophilia was assessed in a logistic regression model.
Results
Patients with sputum eosinophilia had significantly higher levels of eNO (29 vs. 18 ppb,
p
= 0.01) than those without. The difference in serum total IgE (168 vs. 84.9 IU/ml,
p
= 0.057) and percentages of positive allergen test results (48.3 vs. 29.5 %,
p
= 0.082) showed a trend toward significance. The sputum eosinophil level was significantly correlated to the eNO level (
r
= 0.485,
p
< 0.001). The eNO level at the cutoff of 23.5 ppb had the maximum sum of sensitivity (62.1 %) and specificity (70.5 %). The unadjusted and adjusted odds ratios of a higher eNO level (>23.5 ppb) in the prediction of sputum eosinophilia were 3.909 (confidence interval (CI) 1.542–9.91,
p
= 0.004) and 4.329 (CI 1.306–14.356,
p
= 0.017), respectively.
Conclusions
eNO is a good marker to identify COPD patients with eosinophilic airway inflammation.</description><identifier>ISSN: 0341-2040</identifier><identifier>EISSN: 1432-1750</identifier><identifier>DOI: 10.1007/s00408-014-9591-8</identifier><identifier>PMID: 24816967</identifier><identifier>CODEN: LUNGD9</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Aged ; Aged, 80 and over ; Area Under Curve ; Biomarkers ; Biomarkers - metabolism ; Breath Tests ; Care and treatment ; Cellular biology ; Chronic obstructive lung disease ; Chronic obstructive pulmonary disease ; Complications and side effects ; Development and progression ; Diagnosis ; Eosinophil Cationic Protein - metabolism ; Eosinophilia ; Exhalation ; Female ; Genetic aspects ; Health aspects ; Humans ; Immunoglobulin E - blood ; Inflammation ; Logistic Models ; Lung diseases, Obstructive ; Male ; Measurement ; Medicine ; Medicine & Public Health ; Nitric oxide ; Nitric Oxide - metabolism ; Odds Ratio ; Patient outcomes ; Physiological aspects ; Pneumology/Respiratory System ; Pneumonia - diagnosis ; Pneumonia - metabolism ; Pneumonia - physiopathology ; Predictive Value of Tests ; Prospective Studies ; Pulmonary Disease, Chronic Obstructive - diagnosis ; Pulmonary Disease, Chronic Obstructive - metabolism ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Pulmonary Eosinophilia - diagnosis ; Pulmonary Eosinophilia - metabolism ; Pulmonary Eosinophilia - physiopathology ; Respiratory Function Tests ; Risk factors ; ROC Curve ; Sputum - cytology ; Sputum - metabolism</subject><ispartof>Lung, 2014-08, Vol.192 (4), p.499-504</ispartof><rights>Springer Science+Business Media New York 2014</rights><rights>COPYRIGHT 2014 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c747t-c6efc97c0398015411fef9001bdb96e41c9d30efe0d59b4a437b7ae0d860f2823</citedby><cites>FETCH-LOGICAL-c747t-c6efc97c0398015411fef9001bdb96e41c9d30efe0d59b4a437b7ae0d860f2823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00408-014-9591-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00408-014-9591-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24816967$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chou, Kun-Ta</creatorcontrib><creatorcontrib>Su, Kang-Cheng</creatorcontrib><creatorcontrib>Huang, Shiang-Fen</creatorcontrib><creatorcontrib>Hsiao, Yi-Han</creatorcontrib><creatorcontrib>Tseng, Ching-Min</creatorcontrib><creatorcontrib>Su, Vincent Yi-Fong</creatorcontrib><creatorcontrib>Hung, Shih-Chieh</creatorcontrib><creatorcontrib>Perng, Diahn-Warng</creatorcontrib><title>Exhaled Nitric Oxide Predicts Eosinophilic Airway Inflammation in COPD</title><title>Lung</title><addtitle>Lung</addtitle><addtitle>Lung</addtitle><description>Purpose
Chronic obstructive pulmonary disease (COPD) with eosinophilic airway inflammation may represent a unique phenotype, possibly with shared features of COPD and asthma. The role of exhaled nitric oxide (eNO) in identifying COPD patients with sputum eosinophilia was examined in this study.
Methods
Ninety COPD patients without past medical history of asthma or allergic diseases were prospectively enrolled, and their eNO, lung function, and cellular profile of induced sputum were measured. Eosinophil cationic protein and IgE in sputum and venous blood also were determined. Subjects with and without sputum eosinophilia (>3 %) were compared. The role of eNO in the prediction of sputum eosinophilia was assessed in a logistic regression model.
Results
Patients with sputum eosinophilia had significantly higher levels of eNO (29 vs. 18 ppb,
p
= 0.01) than those without. The difference in serum total IgE (168 vs. 84.9 IU/ml,
p
= 0.057) and percentages of positive allergen test results (48.3 vs. 29.5 %,
p
= 0.082) showed a trend toward significance. The sputum eosinophil level was significantly correlated to the eNO level (
r
= 0.485,
p
< 0.001). The eNO level at the cutoff of 23.5 ppb had the maximum sum of sensitivity (62.1 %) and specificity (70.5 %). The unadjusted and adjusted odds ratios of a higher eNO level (>23.5 ppb) in the prediction of sputum eosinophilia were 3.909 (confidence interval (CI) 1.542–9.91,
p
= 0.004) and 4.329 (CI 1.306–14.356,
p
= 0.017), respectively.
Conclusions
eNO is a good marker to identify COPD patients with eosinophilic airway inflammation.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Area Under Curve</subject><subject>Biomarkers</subject><subject>Biomarkers - metabolism</subject><subject>Breath Tests</subject><subject>Care and treatment</subject><subject>Cellular biology</subject><subject>Chronic obstructive lung disease</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Complications and side effects</subject><subject>Development and progression</subject><subject>Diagnosis</subject><subject>Eosinophil Cationic Protein - metabolism</subject><subject>Eosinophilia</subject><subject>Exhalation</subject><subject>Female</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Immunoglobulin E - blood</subject><subject>Inflammation</subject><subject>Logistic Models</subject><subject>Lung diseases, Obstructive</subject><subject>Male</subject><subject>Measurement</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - metabolism</subject><subject>Odds Ratio</subject><subject>Patient outcomes</subject><subject>Physiological aspects</subject><subject>Pneumology/Respiratory System</subject><subject>Pneumonia - diagnosis</subject><subject>Pneumonia - metabolism</subject><subject>Pneumonia - physiopathology</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Pulmonary Disease, Chronic Obstructive - diagnosis</subject><subject>Pulmonary Disease, Chronic Obstructive - metabolism</subject><subject>Pulmonary Disease, Chronic Obstructive - physiopathology</subject><subject>Pulmonary Eosinophilia - diagnosis</subject><subject>Pulmonary Eosinophilia - metabolism</subject><subject>Pulmonary Eosinophilia - physiopathology</subject><subject>Respiratory Function Tests</subject><subject>Risk factors</subject><subject>ROC Curve</subject><subject>Sputum - cytology</subject><subject>Sputum - metabolism</subject><issn>0341-2040</issn><issn>1432-1750</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkl9v0zAUxSMEYmXwAXhBkZAQLxnXseM_j1XpYNJE9wDPluvYrafELnaibd8eVx2QoTJNfrBs_865V76nKN4iOEMA7FMCIMArQKQSjUAVf1bMEMF1hVgDz4sZYIKqOjMnxauUrgEQo6h5WZzUhCMqKJsV58vbrepMW35zQ3S6XN261pRX0bROD6lchuR82G1dl9_mLt6ou_LC2071vRpc8KXz5WJ19fl18cKqLpk39_tp8eN8-X3xtbpcfblYzC8rzQgbKk2N1YJpwIIDaghC1liR-1q3a0ENQVq0GIw10DZiTRTBbM1UPnEKtuY1Pi0-Hnx3MfwcTRpk75I2Xae8CWOSqKGUN0Awyuj7f9DrMEafu8sUocC4EPCX2uRfkM7bMESl96ZyTjAGwkhNH6Uwxw1rWC0yVR2hNsabqLrgjXX5-oHrU_ip_9kRPq_W9E4fLfAkwbTCh4lga1Q3bFPoxv2o00PnR8GpIzqAOoaUorFyF12v4p1EIPchlocQyxxiuQ-x5Fnz7n5y47o37R_F79RmoD4AKT_5jYmT0f7X9RfPYPSL</recordid><startdate>20140801</startdate><enddate>20140801</enddate><creator>Chou, Kun-Ta</creator><creator>Su, Kang-Cheng</creator><creator>Huang, Shiang-Fen</creator><creator>Hsiao, Yi-Han</creator><creator>Tseng, Ching-Min</creator><creator>Su, Vincent Yi-Fong</creator><creator>Hung, Shih-Chieh</creator><creator>Perng, Diahn-Warng</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7T5</scope></search><sort><creationdate>20140801</creationdate><title>Exhaled Nitric Oxide Predicts Eosinophilic Airway Inflammation in COPD</title><author>Chou, Kun-Ta ; Su, Kang-Cheng ; Huang, Shiang-Fen ; Hsiao, Yi-Han ; Tseng, Ching-Min ; Su, Vincent Yi-Fong ; Hung, Shih-Chieh ; Perng, Diahn-Warng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c747t-c6efc97c0398015411fef9001bdb96e41c9d30efe0d59b4a437b7ae0d860f2823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Area Under Curve</topic><topic>Biomarkers</topic><topic>Biomarkers - metabolism</topic><topic>Breath Tests</topic><topic>Care and treatment</topic><topic>Cellular biology</topic><topic>Chronic obstructive lung disease</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Complications and side effects</topic><topic>Development and progression</topic><topic>Diagnosis</topic><topic>Eosinophil Cationic Protein - metabolism</topic><topic>Eosinophilia</topic><topic>Exhalation</topic><topic>Female</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Immunoglobulin E - blood</topic><topic>Inflammation</topic><topic>Logistic Models</topic><topic>Lung diseases, Obstructive</topic><topic>Male</topic><topic>Measurement</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - metabolism</topic><topic>Odds Ratio</topic><topic>Patient outcomes</topic><topic>Physiological aspects</topic><topic>Pneumology/Respiratory System</topic><topic>Pneumonia - diagnosis</topic><topic>Pneumonia - metabolism</topic><topic>Pneumonia - physiopathology</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Pulmonary Disease, Chronic Obstructive - diagnosis</topic><topic>Pulmonary Disease, Chronic Obstructive - metabolism</topic><topic>Pulmonary Disease, Chronic Obstructive - physiopathology</topic><topic>Pulmonary Eosinophilia - diagnosis</topic><topic>Pulmonary Eosinophilia - metabolism</topic><topic>Pulmonary Eosinophilia - physiopathology</topic><topic>Respiratory Function Tests</topic><topic>Risk factors</topic><topic>ROC Curve</topic><topic>Sputum - cytology</topic><topic>Sputum - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chou, Kun-Ta</creatorcontrib><creatorcontrib>Su, Kang-Cheng</creatorcontrib><creatorcontrib>Huang, Shiang-Fen</creatorcontrib><creatorcontrib>Hsiao, Yi-Han</creatorcontrib><creatorcontrib>Tseng, Ching-Min</creatorcontrib><creatorcontrib>Su, Vincent Yi-Fong</creatorcontrib><creatorcontrib>Hung, Shih-Chieh</creatorcontrib><creatorcontrib>Perng, Diahn-Warng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Immunology Abstracts</collection><jtitle>Lung</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chou, Kun-Ta</au><au>Su, Kang-Cheng</au><au>Huang, Shiang-Fen</au><au>Hsiao, Yi-Han</au><au>Tseng, Ching-Min</au><au>Su, Vincent Yi-Fong</au><au>Hung, Shih-Chieh</au><au>Perng, Diahn-Warng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exhaled Nitric Oxide Predicts Eosinophilic Airway Inflammation in COPD</atitle><jtitle>Lung</jtitle><stitle>Lung</stitle><addtitle>Lung</addtitle><date>2014-08-01</date><risdate>2014</risdate><volume>192</volume><issue>4</issue><spage>499</spage><epage>504</epage><pages>499-504</pages><issn>0341-2040</issn><eissn>1432-1750</eissn><coden>LUNGD9</coden><abstract>Purpose
Chronic obstructive pulmonary disease (COPD) with eosinophilic airway inflammation may represent a unique phenotype, possibly with shared features of COPD and asthma. The role of exhaled nitric oxide (eNO) in identifying COPD patients with sputum eosinophilia was examined in this study.
Methods
Ninety COPD patients without past medical history of asthma or allergic diseases were prospectively enrolled, and their eNO, lung function, and cellular profile of induced sputum were measured. Eosinophil cationic protein and IgE in sputum and venous blood also were determined. Subjects with and without sputum eosinophilia (>3 %) were compared. The role of eNO in the prediction of sputum eosinophilia was assessed in a logistic regression model.
Results
Patients with sputum eosinophilia had significantly higher levels of eNO (29 vs. 18 ppb,
p
= 0.01) than those without. The difference in serum total IgE (168 vs. 84.9 IU/ml,
p
= 0.057) and percentages of positive allergen test results (48.3 vs. 29.5 %,
p
= 0.082) showed a trend toward significance. The sputum eosinophil level was significantly correlated to the eNO level (
r
= 0.485,
p
< 0.001). The eNO level at the cutoff of 23.5 ppb had the maximum sum of sensitivity (62.1 %) and specificity (70.5 %). The unadjusted and adjusted odds ratios of a higher eNO level (>23.5 ppb) in the prediction of sputum eosinophilia were 3.909 (confidence interval (CI) 1.542–9.91,
p
= 0.004) and 4.329 (CI 1.306–14.356,
p
= 0.017), respectively.
Conclusions
eNO is a good marker to identify COPD patients with eosinophilic airway inflammation.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>24816967</pmid><doi>10.1007/s00408-014-9591-8</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0341-2040 |
| ispartof | Lung, 2014-08, Vol.192 (4), p.499-504 |
| issn | 0341-2040 1432-1750 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1566850431 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Aged Aged, 80 and over Area Under Curve Biomarkers Biomarkers - metabolism Breath Tests Care and treatment Cellular biology Chronic obstructive lung disease Chronic obstructive pulmonary disease Complications and side effects Development and progression Diagnosis Eosinophil Cationic Protein - metabolism Eosinophilia Exhalation Female Genetic aspects Health aspects Humans Immunoglobulin E - blood Inflammation Logistic Models Lung diseases, Obstructive Male Measurement Medicine Medicine & Public Health Nitric oxide Nitric Oxide - metabolism Odds Ratio Patient outcomes Physiological aspects Pneumology/Respiratory System Pneumonia - diagnosis Pneumonia - metabolism Pneumonia - physiopathology Predictive Value of Tests Prospective Studies Pulmonary Disease, Chronic Obstructive - diagnosis Pulmonary Disease, Chronic Obstructive - metabolism Pulmonary Disease, Chronic Obstructive - physiopathology Pulmonary Eosinophilia - diagnosis Pulmonary Eosinophilia - metabolism Pulmonary Eosinophilia - physiopathology Respiratory Function Tests Risk factors ROC Curve Sputum - cytology Sputum - metabolism |
| title | Exhaled Nitric Oxide Predicts Eosinophilic Airway Inflammation in COPD |
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