Minichromosome maintenance protein 7 is a risk factor for recurrence in patients with Dukes C colorectal cancer
It has been hypothesized that minichromosome maintenance (MCM) proteins, which are replicative control factors, can be used to detect tumor proliferation. The aim of the present study was to investigate the expression of MCM in colorectal cancer tissues and correlate it to clinical outcomes. The stu...
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| Veröffentlicht in: | Anticancer research 2014-08, Vol.34 (8), p.4569-4575 |
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| creator | Ishibashi, Yoshiaki Kinugasa, Tetsushi Akagi, Yoshito Ohchi, Takafumi Gotanda, Yukito Tanaka, Natsuki Fujino, Shinya Yuge, Kotaro Kibe, Shiro Yoshida, Naohiro Mizobe, Tomoaki Oka, Yosuke Yoshida, Takefumi Shirouzu, Kazuo |
| description | It has been hypothesized that minichromosome maintenance (MCM) proteins, which are replicative control factors, can be used to detect tumor proliferation. The aim of the present study was to investigate the expression of MCM in colorectal cancer tissues and correlate it to clinical outcomes.
The study included 145 patients with colorectal cancer who underwent curative surgery, from January 2002 until December 2004, at the Kurume University Hospital in Fukuoka, Japan. The median follow-up duration was 87 months. The expression of MCM7 in tissues was studied by immuno-histochemical staining. The labeling index (LI) of MCM7 was calculated by dividing the number of positively-stained cells by the total number of cells counted. We divided samples into two groups: positive (MCM7 LI 76% or higher) and negative (MCM7 LI less than 76%).
In patients with Dukes A and B, there were no significant differences in either overall survival (OS) or recurrence-free survival (RFS) between patents with MCM7-positive and those with MCM7-negative disease. On the other hand, in patients with Dukes C, there was significantly worse OS and RFS for patients with MCM7-positive compared to those with MCM7-negative disease.
We found that the expression of MCM7 is an independent risk factor for RFS in patients with Dukes C colorectal cancer. Further studies are required to investigate the validity of MCM7 protein expression for its potential clinical use in colorectal cancer therapy and prognosis. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1566849914</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1566849914</sourcerecordid><originalsourceid>FETCH-LOGICAL-p244t-3e141d763a95abe52033d4cd1f0821dac4a14cd268f845119f503fa3c59cb05f3</originalsourceid><addsrcrecordid>eNqN0E1LxDAQBuAgiruu_gXJ0Ushn01zlPUTVrzouWTTCRu3TWqSIv57u7jePQzDDA8vzJygJVWaVkpycoqWhElSKULkAl3k_EFIXeuGn6PFvFeSErpE8cUHb3cpDjHHAfBgfCgQTLCAxxQL-IAV9hkbnHzeY2dsiQm7uRLYKSU4yBmNpngIJeMvX3b4btpDxmtsYx9nV0yP7SEzXaIzZ_oMV8e-Qu8P92_rp2rz-vi8vt1UIxOiVByooJ2qudHSbEEywnknbEcdaRjtjBWGziOrG9cISal2knBnuJXabol0fIVufnPnIz4nyKUdfLbQ9yZAnHJLZV03Qmsq_kElIUpJxmZ6faTTdoCuHZMfTPpu__7JfwBWX3K0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1550077522</pqid></control><display><type>article</type><title>Minichromosome maintenance protein 7 is a risk factor for recurrence in patients with Dukes C colorectal cancer</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Ishibashi, Yoshiaki ; Kinugasa, Tetsushi ; Akagi, Yoshito ; Ohchi, Takafumi ; Gotanda, Yukito ; Tanaka, Natsuki ; Fujino, Shinya ; Yuge, Kotaro ; Kibe, Shiro ; Yoshida, Naohiro ; Mizobe, Tomoaki ; Oka, Yosuke ; Yoshida, Takefumi ; Shirouzu, Kazuo</creator><creatorcontrib>Ishibashi, Yoshiaki ; Kinugasa, Tetsushi ; Akagi, Yoshito ; Ohchi, Takafumi ; Gotanda, Yukito ; Tanaka, Natsuki ; Fujino, Shinya ; Yuge, Kotaro ; Kibe, Shiro ; Yoshida, Naohiro ; Mizobe, Tomoaki ; Oka, Yosuke ; Yoshida, Takefumi ; Shirouzu, Kazuo</creatorcontrib><description>It has been hypothesized that minichromosome maintenance (MCM) proteins, which are replicative control factors, can be used to detect tumor proliferation. The aim of the present study was to investigate the expression of MCM in colorectal cancer tissues and correlate it to clinical outcomes.
The study included 145 patients with colorectal cancer who underwent curative surgery, from January 2002 until December 2004, at the Kurume University Hospital in Fukuoka, Japan. The median follow-up duration was 87 months. The expression of MCM7 in tissues was studied by immuno-histochemical staining. The labeling index (LI) of MCM7 was calculated by dividing the number of positively-stained cells by the total number of cells counted. We divided samples into two groups: positive (MCM7 LI 76% or higher) and negative (MCM7 LI less than 76%).
In patients with Dukes A and B, there were no significant differences in either overall survival (OS) or recurrence-free survival (RFS) between patents with MCM7-positive and those with MCM7-negative disease. On the other hand, in patients with Dukes C, there was significantly worse OS and RFS for patients with MCM7-positive compared to those with MCM7-negative disease.
We found that the expression of MCM7 is an independent risk factor for RFS in patients with Dukes C colorectal cancer. Further studies are required to investigate the validity of MCM7 protein expression for its potential clinical use in colorectal cancer therapy and prognosis.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 25075101</identifier><language>eng</language><publisher>Greece</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Colorectal Neoplasms - etiology ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; Female ; Humans ; Immunohistochemistry ; Ki-67 Antigen - analysis ; Male ; Middle Aged ; Minichromosome Maintenance Complex Component 7 - physiology ; Neoplasm Recurrence, Local - etiology ; Proportional Hazards Models ; Risk Factors</subject><ispartof>Anticancer research, 2014-08, Vol.34 (8), p.4569-4575</ispartof><rights>Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25075101$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ishibashi, Yoshiaki</creatorcontrib><creatorcontrib>Kinugasa, Tetsushi</creatorcontrib><creatorcontrib>Akagi, Yoshito</creatorcontrib><creatorcontrib>Ohchi, Takafumi</creatorcontrib><creatorcontrib>Gotanda, Yukito</creatorcontrib><creatorcontrib>Tanaka, Natsuki</creatorcontrib><creatorcontrib>Fujino, Shinya</creatorcontrib><creatorcontrib>Yuge, Kotaro</creatorcontrib><creatorcontrib>Kibe, Shiro</creatorcontrib><creatorcontrib>Yoshida, Naohiro</creatorcontrib><creatorcontrib>Mizobe, Tomoaki</creatorcontrib><creatorcontrib>Oka, Yosuke</creatorcontrib><creatorcontrib>Yoshida, Takefumi</creatorcontrib><creatorcontrib>Shirouzu, Kazuo</creatorcontrib><title>Minichromosome maintenance protein 7 is a risk factor for recurrence in patients with Dukes C colorectal cancer</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>It has been hypothesized that minichromosome maintenance (MCM) proteins, which are replicative control factors, can be used to detect tumor proliferation. The aim of the present study was to investigate the expression of MCM in colorectal cancer tissues and correlate it to clinical outcomes.
The study included 145 patients with colorectal cancer who underwent curative surgery, from January 2002 until December 2004, at the Kurume University Hospital in Fukuoka, Japan. The median follow-up duration was 87 months. The expression of MCM7 in tissues was studied by immuno-histochemical staining. The labeling index (LI) of MCM7 was calculated by dividing the number of positively-stained cells by the total number of cells counted. We divided samples into two groups: positive (MCM7 LI 76% or higher) and negative (MCM7 LI less than 76%).
In patients with Dukes A and B, there were no significant differences in either overall survival (OS) or recurrence-free survival (RFS) between patents with MCM7-positive and those with MCM7-negative disease. On the other hand, in patients with Dukes C, there was significantly worse OS and RFS for patients with MCM7-positive compared to those with MCM7-negative disease.
We found that the expression of MCM7 is an independent risk factor for RFS in patients with Dukes C colorectal cancer. Further studies are required to investigate the validity of MCM7 protein expression for its potential clinical use in colorectal cancer therapy and prognosis.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Colorectal Neoplasms - etiology</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Ki-67 Antigen - analysis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Minichromosome Maintenance Complex Component 7 - physiology</subject><subject>Neoplasm Recurrence, Local - etiology</subject><subject>Proportional Hazards Models</subject><subject>Risk Factors</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0E1LxDAQBuAgiruu_gXJ0Ushn01zlPUTVrzouWTTCRu3TWqSIv57u7jePQzDDA8vzJygJVWaVkpycoqWhElSKULkAl3k_EFIXeuGn6PFvFeSErpE8cUHb3cpDjHHAfBgfCgQTLCAxxQL-IAV9hkbnHzeY2dsiQm7uRLYKSU4yBmNpngIJeMvX3b4btpDxmtsYx9nV0yP7SEzXaIzZ_oMV8e-Qu8P92_rp2rz-vi8vt1UIxOiVByooJ2qudHSbEEywnknbEcdaRjtjBWGziOrG9cISal2knBnuJXabol0fIVufnPnIz4nyKUdfLbQ9yZAnHJLZV03Qmsq_kElIUpJxmZ6faTTdoCuHZMfTPpu__7JfwBWX3K0</recordid><startdate>201408</startdate><enddate>201408</enddate><creator>Ishibashi, Yoshiaki</creator><creator>Kinugasa, Tetsushi</creator><creator>Akagi, Yoshito</creator><creator>Ohchi, Takafumi</creator><creator>Gotanda, Yukito</creator><creator>Tanaka, Natsuki</creator><creator>Fujino, Shinya</creator><creator>Yuge, Kotaro</creator><creator>Kibe, Shiro</creator><creator>Yoshida, Naohiro</creator><creator>Mizobe, Tomoaki</creator><creator>Oka, Yosuke</creator><creator>Yoshida, Takefumi</creator><creator>Shirouzu, Kazuo</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>201408</creationdate><title>Minichromosome maintenance protein 7 is a risk factor for recurrence in patients with Dukes C colorectal cancer</title><author>Ishibashi, Yoshiaki ; Kinugasa, Tetsushi ; Akagi, Yoshito ; Ohchi, Takafumi ; Gotanda, Yukito ; Tanaka, Natsuki ; Fujino, Shinya ; Yuge, Kotaro ; Kibe, Shiro ; Yoshida, Naohiro ; Mizobe, Tomoaki ; Oka, Yosuke ; Yoshida, Takefumi ; Shirouzu, Kazuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p244t-3e141d763a95abe52033d4cd1f0821dac4a14cd268f845119f503fa3c59cb05f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Colorectal Neoplasms - etiology</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Ki-67 Antigen - analysis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Minichromosome Maintenance Complex Component 7 - physiology</topic><topic>Neoplasm Recurrence, Local - etiology</topic><topic>Proportional Hazards Models</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ishibashi, Yoshiaki</creatorcontrib><creatorcontrib>Kinugasa, Tetsushi</creatorcontrib><creatorcontrib>Akagi, Yoshito</creatorcontrib><creatorcontrib>Ohchi, Takafumi</creatorcontrib><creatorcontrib>Gotanda, Yukito</creatorcontrib><creatorcontrib>Tanaka, Natsuki</creatorcontrib><creatorcontrib>Fujino, Shinya</creatorcontrib><creatorcontrib>Yuge, Kotaro</creatorcontrib><creatorcontrib>Kibe, Shiro</creatorcontrib><creatorcontrib>Yoshida, Naohiro</creatorcontrib><creatorcontrib>Mizobe, Tomoaki</creatorcontrib><creatorcontrib>Oka, Yosuke</creatorcontrib><creatorcontrib>Yoshida, Takefumi</creatorcontrib><creatorcontrib>Shirouzu, Kazuo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishibashi, Yoshiaki</au><au>Kinugasa, Tetsushi</au><au>Akagi, Yoshito</au><au>Ohchi, Takafumi</au><au>Gotanda, Yukito</au><au>Tanaka, Natsuki</au><au>Fujino, Shinya</au><au>Yuge, Kotaro</au><au>Kibe, Shiro</au><au>Yoshida, Naohiro</au><au>Mizobe, Tomoaki</au><au>Oka, Yosuke</au><au>Yoshida, Takefumi</au><au>Shirouzu, Kazuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Minichromosome maintenance protein 7 is a risk factor for recurrence in patients with Dukes C colorectal cancer</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2014-08</date><risdate>2014</risdate><volume>34</volume><issue>8</issue><spage>4569</spage><epage>4575</epage><pages>4569-4575</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>It has been hypothesized that minichromosome maintenance (MCM) proteins, which are replicative control factors, can be used to detect tumor proliferation. The aim of the present study was to investigate the expression of MCM in colorectal cancer tissues and correlate it to clinical outcomes.
The study included 145 patients with colorectal cancer who underwent curative surgery, from January 2002 until December 2004, at the Kurume University Hospital in Fukuoka, Japan. The median follow-up duration was 87 months. The expression of MCM7 in tissues was studied by immuno-histochemical staining. The labeling index (LI) of MCM7 was calculated by dividing the number of positively-stained cells by the total number of cells counted. We divided samples into two groups: positive (MCM7 LI 76% or higher) and negative (MCM7 LI less than 76%).
In patients with Dukes A and B, there were no significant differences in either overall survival (OS) or recurrence-free survival (RFS) between patents with MCM7-positive and those with MCM7-negative disease. On the other hand, in patients with Dukes C, there was significantly worse OS and RFS for patients with MCM7-positive compared to those with MCM7-negative disease.
We found that the expression of MCM7 is an independent risk factor for RFS in patients with Dukes C colorectal cancer. Further studies are required to investigate the validity of MCM7 protein expression for its potential clinical use in colorectal cancer therapy and prognosis.</abstract><cop>Greece</cop><pmid>25075101</pmid><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Colorectal Neoplasms - etiology Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Female Humans Immunohistochemistry Ki-67 Antigen - analysis Male Middle Aged Minichromosome Maintenance Complex Component 7 - physiology Neoplasm Recurrence, Local - etiology Proportional Hazards Models Risk Factors |
| title | Minichromosome maintenance protein 7 is a risk factor for recurrence in patients with Dukes C colorectal cancer |
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