Enhanced LPS-induced peritonitis in mice deficiency of cullin 4B in macrophages

Cullin 4B (CUL4B), a member of the cullin protein family, is a scaffold protein of the CUL4B–RING–E3 ligase complex that ubiquitinates intracellular proteins.CUL4B’s targets include cell cycle-regulated proteins and DNA replication-related molecules. In this study, we generated myeloid-specific Cul4...

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Veröffentlicht in:	Genes and immunity 2014-09, Vol.15 (6), p.404-412
Hauptverfasser:	Hung, M-H, Jian, Y-R, Tsao, C-C, Lin, S-W, Chuang, Y-H
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/2504/342 Animals Biomedical and Life Sciences Biomedicine Blood Body Weight - immunology Bone marrow Bone Marrow Cells - immunology Bone Marrow Cells - metabolism Cancer Research Care and treatment Cell cycle Cell Cycle - genetics Cell Cycle - immunology Cell Line, Tumor Cell Proliferation - genetics Cellular proteins Chemokines Chemokines - immunology Chemokines - metabolism Cullin Cullin Proteins - genetics Cullin Proteins - immunology Cullin Proteins - metabolism Cytokines Deoxyribonucleic acid DNA DNA biosynthesis Gene Expression Gene Expression - immunology Genes Genetic aspects Human Genetics Immune response Immune system Immunity, Innate - genetics Immunity, Innate - immunology Immunoassay Immunology Inflammation Innate immunity Intellectual disabilities Interleukin 6 Interleukin-6 - genetics Interleukin-6 - immunology Interleukin-6 - metabolism Leukocytes - immunology Leukocytes - metabolism Lipopolysaccharides Macrophages Macrophages - immunology Macrophages - metabolism Medical laboratories Mice Mice, Knockout original-article Pathogens Peritonitis Peritonitis - chemically induced Peritonitis - genetics Peritonitis - immunology Phagocytosis - genetics Phagocytosis - immunology Properties Proteins Replication Reverse Transcriptase Polymerase Chain Reaction Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α Ubiquitin-protein ligase
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