The prognostic impact of MGMT expression on low-grade gangliogliomas: a clinicopathological and immunohistochemical study

Ganglioglioma (GG) is an uncommon brain parenchymal neoplasm. Although most cases have indolent clinical behaviour, a subgroup of GGs does recur, especially in patients with unresectable disease. O6-methylguanine DNA methyltransferase (MGMT) is a DNA repair protein that removes mutagenic and cytotox...

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Veröffentlicht in:	Folia neuropathologica 2013, Vol.51 (4), p.275-282
Hauptverfasser:	Chang, I-Wei, Hsu, Chao-Tien, Lin, Jui-Wei, Hung, Chih-Hsin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biomarkers, Tumor - biosynthesis Biomarkers, Tumor - genetics Brain Neoplasms - diagnosis Brain Neoplasms - genetics Brain Neoplasms - metabolism Child Child, Preschool DNA Modification Methylases - biosynthesis DNA Modification Methylases - genetics DNA Repair Enzymes - biosynthesis DNA Repair Enzymes - genetics Female Follow-Up Studies Ganglioglioma - diagnosis Ganglioglioma - genetics Ganglioglioma - metabolism Gene Expression Regulation, Neoplastic Humans Male Neoplasm Grading Neoplasm Recurrence, Local - diagnosis Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - metabolism Prognosis Retrospective Studies Tumor Suppressor Proteins - biosynthesis Tumor Suppressor Proteins - genetics Young Adult
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