Assessment of the tracer delay effect in whole-brain computed tomography perfusion: results in patients without known neuroanatomic abnormalities
Whole-brain computed tomography perfusion (CTP) data sets generated by tracer delay-insensitive singular value decomposition plus (SVD+) and standard singular value decomposition (sSVD) deconvolution algorithms were evaluated to quantify relatedness and discrepancies in CTP results. Twenty females w...
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| Veröffentlicht in: | Journal of computer assisted tomography 2013-03, Vol.37 (2), p.212-221 |
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| container_title | Journal of computer assisted tomography |
| container_volume | 37 |
| creator | Hanson, Eric H Roach, Cayce J Day, Kirtly J Peters, Keith R Bradley, Jr, William G Ghosh, Kaushik Patton, Phillip W McMurray, Robert C Orrison, Jr, William W |
| description | Whole-brain computed tomography perfusion (CTP) data sets generated by tracer delay-insensitive singular value decomposition plus (SVD+) and standard singular value decomposition (sSVD) deconvolution algorithms were evaluated to quantify relatedness and discrepancies in CTP results.
Twenty females with symmetrical hemispheric CTP maps indicative of brain tissue without apparent abnormalities were studied. Tissue-specific CTP values were analyzed.
Standard SVD values were higher than SVD+ for cerebral blood flow. Other CTP values had minimal differences across brain regions. All simple linear regression models were statistically significant (P < 0.05) except for cerebral blood flow in white matter (P = 0.06). Cerebral blood volume had a good model fit, and mean transit time, a poor fit.
Corresponding fitted CTP values for sSVD and SVD+ based on regression equations for brain-tissue types are presented. Additional research is required to compare SVD+ and sSVD in disease states when significant hemodynamic brain alterations are present. |
| doi_str_mv | 10.1097/RCT.0b013e31828004bb |
| format | Article |
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Twenty females with symmetrical hemispheric CTP maps indicative of brain tissue without apparent abnormalities were studied. Tissue-specific CTP values were analyzed.
Standard SVD values were higher than SVD+ for cerebral blood flow. Other CTP values had minimal differences across brain regions. All simple linear regression models were statistically significant (P < 0.05) except for cerebral blood flow in white matter (P = 0.06). Cerebral blood volume had a good model fit, and mean transit time, a poor fit.
Corresponding fitted CTP values for sSVD and SVD+ based on regression equations for brain-tissue types are presented. Additional research is required to compare SVD+ and sSVD in disease states when significant hemodynamic brain alterations are present.</description><identifier>ISSN: 0363-8715</identifier><identifier>EISSN: 1532-3145</identifier><identifier>DOI: 10.1097/RCT.0b013e31828004bb</identifier><identifier>PMID: 23493210</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Algorithms ; Area Under Curve ; Blood Volume ; Brain - blood supply ; Brain - diagnostic imaging ; Brain Ischemia - diagnostic imaging ; Cerebrovascular Circulation ; Craniocerebral Trauma - diagnostic imaging ; Female ; Headache - diagnostic imaging ; Humans ; Linear Models ; Middle Aged ; Radiation Dosage ; Reference Values ; Retrospective Studies ; Tomography, X-Ray Computed - methods ; Triiodobenzoic Acids - pharmacokinetics</subject><ispartof>Journal of computer assisted tomography, 2013-03, Vol.37 (2), p.212-221</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c289t-3908e2e53641d21c36dc508e62f8394f3176c3e8b033df52f061f0295d8ea3f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23493210$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hanson, Eric H</creatorcontrib><creatorcontrib>Roach, Cayce J</creatorcontrib><creatorcontrib>Day, Kirtly J</creatorcontrib><creatorcontrib>Peters, Keith R</creatorcontrib><creatorcontrib>Bradley, Jr, William G</creatorcontrib><creatorcontrib>Ghosh, Kaushik</creatorcontrib><creatorcontrib>Patton, Phillip W</creatorcontrib><creatorcontrib>McMurray, Robert C</creatorcontrib><creatorcontrib>Orrison, Jr, William W</creatorcontrib><title>Assessment of the tracer delay effect in whole-brain computed tomography perfusion: results in patients without known neuroanatomic abnormalities</title><title>Journal of computer assisted tomography</title><addtitle>J Comput Assist Tomogr</addtitle><description>Whole-brain computed tomography perfusion (CTP) data sets generated by tracer delay-insensitive singular value decomposition plus (SVD+) and standard singular value decomposition (sSVD) deconvolution algorithms were evaluated to quantify relatedness and discrepancies in CTP results.
Twenty females with symmetrical hemispheric CTP maps indicative of brain tissue without apparent abnormalities were studied. Tissue-specific CTP values were analyzed.
Standard SVD values were higher than SVD+ for cerebral blood flow. Other CTP values had minimal differences across brain regions. All simple linear regression models were statistically significant (P < 0.05) except for cerebral blood flow in white matter (P = 0.06). Cerebral blood volume had a good model fit, and mean transit time, a poor fit.
Corresponding fitted CTP values for sSVD and SVD+ based on regression equations for brain-tissue types are presented. Additional research is required to compare SVD+ and sSVD in disease states when significant hemodynamic brain alterations are present.</description><subject>Adult</subject><subject>Algorithms</subject><subject>Area Under Curve</subject><subject>Blood Volume</subject><subject>Brain - blood supply</subject><subject>Brain - diagnostic imaging</subject><subject>Brain Ischemia - diagnostic imaging</subject><subject>Cerebrovascular Circulation</subject><subject>Craniocerebral Trauma - diagnostic imaging</subject><subject>Female</subject><subject>Headache - diagnostic imaging</subject><subject>Humans</subject><subject>Linear Models</subject><subject>Middle Aged</subject><subject>Radiation Dosage</subject><subject>Reference Values</subject><subject>Retrospective Studies</subject><subject>Tomography, X-Ray Computed - methods</subject><subject>Triiodobenzoic Acids - pharmacokinetics</subject><issn>0363-8715</issn><issn>1532-3145</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1P3DAQhi3UCrYL_wAhH3sJtT2O1-GGVv1AQqqE6DlynDGbNrFT29Fqfwb_uEZAD1w4zWj0vO8cHkLOObvkrNl8udveX7KOcUDgWmjGZNcdkRWvQVTAZf2BrBgoqPSG1yfkU0q_GeMbAHlMTgTIBgRnK_J4nRKmNKHPNDiad0hzNBYj7XE0B4rOoc108HS_CyNWXTRlt2Gal4w9zWEKD9HMuwOdMbolDcFf0YhpGXN6Ss0mD6U70f2Qd2HJ9I8Pe089LjEYb0p-sNR0PsTJjENh0yn56MyY8Oxlrsmvb1_vtz-q25_fb7bXt5UVuskVNEyjwBqU5L3gFlRv63JSwmlopAO-URZQdwygd7VwTHHHRFP3Gg04Dmvy-bl3juHvgim305AsjqPxGJbU8lopLbVU-n0UQENhy1wT-YzaGFKK6No5DpOJh5az9slbW7y1b72V2MXLh6WbsP8fehUF_wCdcZex</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Hanson, Eric H</creator><creator>Roach, Cayce J</creator><creator>Day, Kirtly J</creator><creator>Peters, Keith R</creator><creator>Bradley, Jr, William G</creator><creator>Ghosh, Kaushik</creator><creator>Patton, Phillip W</creator><creator>McMurray, Robert C</creator><creator>Orrison, Jr, William W</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20130301</creationdate><title>Assessment of the tracer delay effect in whole-brain computed tomography perfusion: results in patients without known neuroanatomic abnormalities</title><author>Hanson, Eric H ; Roach, Cayce J ; Day, Kirtly J ; Peters, Keith R ; Bradley, Jr, William G ; Ghosh, Kaushik ; Patton, Phillip W ; McMurray, Robert C ; Orrison, Jr, William W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c289t-3908e2e53641d21c36dc508e62f8394f3176c3e8b033df52f061f0295d8ea3f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Algorithms</topic><topic>Area Under Curve</topic><topic>Blood Volume</topic><topic>Brain - blood supply</topic><topic>Brain - diagnostic imaging</topic><topic>Brain Ischemia - diagnostic imaging</topic><topic>Cerebrovascular Circulation</topic><topic>Craniocerebral Trauma - diagnostic imaging</topic><topic>Female</topic><topic>Headache - diagnostic imaging</topic><topic>Humans</topic><topic>Linear Models</topic><topic>Middle Aged</topic><topic>Radiation Dosage</topic><topic>Reference Values</topic><topic>Retrospective Studies</topic><topic>Tomography, X-Ray Computed - methods</topic><topic>Triiodobenzoic Acids - pharmacokinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hanson, Eric H</creatorcontrib><creatorcontrib>Roach, Cayce J</creatorcontrib><creatorcontrib>Day, Kirtly J</creatorcontrib><creatorcontrib>Peters, Keith R</creatorcontrib><creatorcontrib>Bradley, Jr, William G</creatorcontrib><creatorcontrib>Ghosh, Kaushik</creatorcontrib><creatorcontrib>Patton, Phillip W</creatorcontrib><creatorcontrib>McMurray, Robert C</creatorcontrib><creatorcontrib>Orrison, Jr, William W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of computer assisted tomography</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hanson, Eric H</au><au>Roach, Cayce J</au><au>Day, Kirtly J</au><au>Peters, Keith R</au><au>Bradley, Jr, William G</au><au>Ghosh, Kaushik</au><au>Patton, Phillip W</au><au>McMurray, Robert C</au><au>Orrison, Jr, William W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of the tracer delay effect in whole-brain computed tomography perfusion: results in patients without known neuroanatomic abnormalities</atitle><jtitle>Journal of computer assisted tomography</jtitle><addtitle>J Comput Assist Tomogr</addtitle><date>2013-03-01</date><risdate>2013</risdate><volume>37</volume><issue>2</issue><spage>212</spage><epage>221</epage><pages>212-221</pages><issn>0363-8715</issn><eissn>1532-3145</eissn><abstract>Whole-brain computed tomography perfusion (CTP) data sets generated by tracer delay-insensitive singular value decomposition plus (SVD+) and standard singular value decomposition (sSVD) deconvolution algorithms were evaluated to quantify relatedness and discrepancies in CTP results.
Twenty females with symmetrical hemispheric CTP maps indicative of brain tissue without apparent abnormalities were studied. Tissue-specific CTP values were analyzed.
Standard SVD values were higher than SVD+ for cerebral blood flow. Other CTP values had minimal differences across brain regions. All simple linear regression models were statistically significant (P < 0.05) except for cerebral blood flow in white matter (P = 0.06). Cerebral blood volume had a good model fit, and mean transit time, a poor fit.
Corresponding fitted CTP values for sSVD and SVD+ based on regression equations for brain-tissue types are presented. Additional research is required to compare SVD+ and sSVD in disease states when significant hemodynamic brain alterations are present.</abstract><cop>United States</cop><pmid>23493210</pmid><doi>10.1097/RCT.0b013e31828004bb</doi><tpages>10</tpages></addata></record> |
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| subjects | Adult Algorithms Area Under Curve Blood Volume Brain - blood supply Brain - diagnostic imaging Brain Ischemia - diagnostic imaging Cerebrovascular Circulation Craniocerebral Trauma - diagnostic imaging Female Headache - diagnostic imaging Humans Linear Models Middle Aged Radiation Dosage Reference Values Retrospective Studies Tomography, X-Ray Computed - methods Triiodobenzoic Acids - pharmacokinetics |
| title | Assessment of the tracer delay effect in whole-brain computed tomography perfusion: results in patients without known neuroanatomic abnormalities |
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