Top-down inputs from the olfactory cortex in the postprandial period promote elimination of granule cells in the olfactory bulb
Elimination of granule cells (GCs) in the olfactory bulb (OB) is not a continual event but is promoted during a short time window in the postprandial period, typically with postprandial sleep. However, the neuronal mechanisms for the enhanced GC elimination during the postprandial period are not und...
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| Veröffentlicht in: | The European journal of neuroscience 2014-09, Vol.40 (5), p.2724-2733 |
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| container_title | The European journal of neuroscience |
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| creator | Komano-Inoue, Sayaka Manabe, Hiroyuki Ota, Mizuho Kusumoto-Yoshida, Ikue Yokoyama, Takeshi K. Mori, Kensaku Yamaguchi, Masahiro |
| description | Elimination of granule cells (GCs) in the olfactory bulb (OB) is not a continual event but is promoted during a short time window in the postprandial period, typically with postprandial sleep. However, the neuronal mechanisms for the enhanced GC elimination during the postprandial period are not understood. Here, we addressed the question of whether top‐down inputs of centrifugal axons from the olfactory cortex (OC) during the postprandial period are involved in the enhanced GC elimination in the OB. Electrical stimulation of centrifugal axons from the OC of anesthetized mice increased GC apoptosis. Furthermore, pharmacological suppression of top‐down inputs from the OC to the OB during the postprandial period of freely behaving mice by γ‐aminobutyric acid (GABA)A receptor agonist injection in the OC significantly decreased GC apoptosis. Remarkable apoptotic GC elimination in the sensory‐deprived OB was also suppressed by pharmacological blockade of top‐down inputs. These results indicate that top‐down inputs from the OC to the OB during the postprandial period are the crucial signal promoting GC elimination, and suggest that the life and death decision of GCs in the OB is determined by the interplay between bottom‐up sensory inputs from the external world and top‐down inputs from the OC.
We previously reported that elimination of granule cells in the olfactory bulb is promoted during postprandial period. We here showed that top‐down inputs from the olfactory cortex to the olfactory bulb during postprandial period are the crucial signal promoting granule cell elimination. Life and death of granule cells is likely determined by the interplay between bottom‐up sensory inputs from the external world and top‐down inputs from the olfactory cortex. |
| doi_str_mv | 10.1111/ejn.12679 |
| format | Article |
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We previously reported that elimination of granule cells in the olfactory bulb is promoted during postprandial period. We here showed that top‐down inputs from the olfactory cortex to the olfactory bulb during postprandial period are the crucial signal promoting granule cell elimination. Life and death of granule cells is likely determined by the interplay between bottom‐up sensory inputs from the external world and top‐down inputs from the olfactory cortex.</description><identifier>ISSN: 0953-816X</identifier><identifier>EISSN: 1460-9568</identifier><identifier>DOI: 10.1111/ejn.12679</identifier><identifier>PMID: 25041475</identifier><language>eng</language><publisher>France: Blackwell Publishing Ltd</publisher><subject>adult neurogenesis ; Animals ; apoptosis ; Apoptosis - drug effects ; Apoptosis - physiology ; Axons - drug effects ; Axons - physiology ; Catheters, Indwelling ; Cell Count ; Electric Stimulation ; Electrodes, Implanted ; Electroencephalography ; GABA-A Receptor Agonists - pharmacology ; Immunohistochemistry ; Male ; mice ; Mice, Inbred C57BL ; Muscimol - pharmacology ; Neurons - drug effects ; Neurons - physiology ; olfactory bulb ; Olfactory Bulb - drug effects ; Olfactory Bulb - physiology ; olfactory cortex ; Olfactory Cortex - drug effects ; Olfactory Cortex - physiology ; Olfactory Pathways - drug effects ; Olfactory Pathways - physiology ; Postprandial Period - drug effects ; Postprandial Period - physiology ; Receptors, GABA-A - metabolism ; Sensory Deprivation - physiology ; top-down inputs</subject><ispartof>The European journal of neuroscience, 2014-09, Vol.40 (5), p.2724-2733</ispartof><rights>2014 Federation of European Neuroscience Societies and John Wiley & Sons Ltd</rights><rights>2014 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5329-a25c4b2b8ec1b1dd932fc9aac63613b1ddfca3bd948723f591cf1b96b04ac0993</citedby><cites>FETCH-LOGICAL-c5329-a25c4b2b8ec1b1dd932fc9aac63613b1ddfca3bd948723f591cf1b96b04ac0993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fejn.12679$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fejn.12679$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25041475$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Komano-Inoue, Sayaka</creatorcontrib><creatorcontrib>Manabe, Hiroyuki</creatorcontrib><creatorcontrib>Ota, Mizuho</creatorcontrib><creatorcontrib>Kusumoto-Yoshida, Ikue</creatorcontrib><creatorcontrib>Yokoyama, Takeshi K.</creatorcontrib><creatorcontrib>Mori, Kensaku</creatorcontrib><creatorcontrib>Yamaguchi, Masahiro</creatorcontrib><title>Top-down inputs from the olfactory cortex in the postprandial period promote elimination of granule cells in the olfactory bulb</title><title>The European journal of neuroscience</title><addtitle>Eur J Neurosci</addtitle><description>Elimination of granule cells (GCs) in the olfactory bulb (OB) is not a continual event but is promoted during a short time window in the postprandial period, typically with postprandial sleep. However, the neuronal mechanisms for the enhanced GC elimination during the postprandial period are not understood. Here, we addressed the question of whether top‐down inputs of centrifugal axons from the olfactory cortex (OC) during the postprandial period are involved in the enhanced GC elimination in the OB. Electrical stimulation of centrifugal axons from the OC of anesthetized mice increased GC apoptosis. Furthermore, pharmacological suppression of top‐down inputs from the OC to the OB during the postprandial period of freely behaving mice by γ‐aminobutyric acid (GABA)A receptor agonist injection in the OC significantly decreased GC apoptosis. Remarkable apoptotic GC elimination in the sensory‐deprived OB was also suppressed by pharmacological blockade of top‐down inputs. These results indicate that top‐down inputs from the OC to the OB during the postprandial period are the crucial signal promoting GC elimination, and suggest that the life and death decision of GCs in the OB is determined by the interplay between bottom‐up sensory inputs from the external world and top‐down inputs from the OC.
We previously reported that elimination of granule cells in the olfactory bulb is promoted during postprandial period. We here showed that top‐down inputs from the olfactory cortex to the olfactory bulb during postprandial period are the crucial signal promoting granule cell elimination. Life and death of granule cells is likely determined by the interplay between bottom‐up sensory inputs from the external world and top‐down inputs from the olfactory cortex.</description><subject>adult neurogenesis</subject><subject>Animals</subject><subject>apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Apoptosis - physiology</subject><subject>Axons - drug effects</subject><subject>Axons - physiology</subject><subject>Catheters, Indwelling</subject><subject>Cell Count</subject><subject>Electric Stimulation</subject><subject>Electrodes, Implanted</subject><subject>Electroencephalography</subject><subject>GABA-A Receptor Agonists - pharmacology</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>mice</subject><subject>Mice, Inbred C57BL</subject><subject>Muscimol - pharmacology</subject><subject>Neurons - drug effects</subject><subject>Neurons - physiology</subject><subject>olfactory bulb</subject><subject>Olfactory Bulb - drug effects</subject><subject>Olfactory Bulb - physiology</subject><subject>olfactory cortex</subject><subject>Olfactory Cortex - drug effects</subject><subject>Olfactory Cortex - physiology</subject><subject>Olfactory Pathways - drug effects</subject><subject>Olfactory Pathways - physiology</subject><subject>Postprandial Period - drug effects</subject><subject>Postprandial Period - physiology</subject><subject>Receptors, GABA-A - metabolism</subject><subject>Sensory Deprivation - physiology</subject><subject>top-down inputs</subject><issn>0953-816X</issn><issn>1460-9568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1PFTEUhhsjkSu64A-YLmUx0I9pZ7o0BK4aPqLB4K5pOy0WO9OhnQnclX_dXi4XVySezUlOnvfNSR4A9jE6xGWO7O1wiAlvxCuwwDVHlWC8fQ0WSDBatZj_3AVvc75FCLW8Zm_ALmGoxnXDFuDPVRyrLt4P0A_jPGXoUuzh9MvCGJwyU0wraGKa7EMBHu9jzNOY1NB5FeBok48dHEsoThba4Hs_qMnHAUYHbwo2BwuNDSFv8_969Rz0O7DjVMj2_dPeAz9OT66OP1dnl8svx5_OKsMoEZUizNSa6NYarHHXCUqcEUoZTjmm64sziupO1G1DqGMCG4e14BrVyiAh6B74uOktr97NNk-y93n9lxpsnLPEjPO2bgmm_4NiRCkhbUEPNqhJMedknRyT71VaSYzkWo0sauSjmsJ-eKqddW-7Z3LrogBHG-DeB7t6uUmefL3YVlabhM9F0HNCpd-SN7Rh8vpiKU-_X387X5KlxPQvdDiqCg</recordid><startdate>201409</startdate><enddate>201409</enddate><creator>Komano-Inoue, Sayaka</creator><creator>Manabe, Hiroyuki</creator><creator>Ota, Mizuho</creator><creator>Kusumoto-Yoshida, Ikue</creator><creator>Yokoyama, Takeshi K.</creator><creator>Mori, Kensaku</creator><creator>Yamaguchi, Masahiro</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>201409</creationdate><title>Top-down inputs from the olfactory cortex in the postprandial period promote elimination of granule cells in the olfactory bulb</title><author>Komano-Inoue, Sayaka ; Manabe, Hiroyuki ; Ota, Mizuho ; Kusumoto-Yoshida, Ikue ; Yokoyama, Takeshi K. ; Mori, Kensaku ; Yamaguchi, Masahiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5329-a25c4b2b8ec1b1dd932fc9aac63613b1ddfca3bd948723f591cf1b96b04ac0993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>adult neurogenesis</topic><topic>Animals</topic><topic>apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Apoptosis - physiology</topic><topic>Axons - drug effects</topic><topic>Axons - physiology</topic><topic>Catheters, Indwelling</topic><topic>Cell Count</topic><topic>Electric Stimulation</topic><topic>Electrodes, Implanted</topic><topic>Electroencephalography</topic><topic>GABA-A Receptor Agonists - pharmacology</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>mice</topic><topic>Mice, Inbred C57BL</topic><topic>Muscimol - pharmacology</topic><topic>Neurons - drug effects</topic><topic>Neurons - physiology</topic><topic>olfactory bulb</topic><topic>Olfactory Bulb - drug effects</topic><topic>Olfactory Bulb - physiology</topic><topic>olfactory cortex</topic><topic>Olfactory Cortex - drug effects</topic><topic>Olfactory Cortex - physiology</topic><topic>Olfactory Pathways - drug effects</topic><topic>Olfactory Pathways - physiology</topic><topic>Postprandial Period - drug effects</topic><topic>Postprandial Period - physiology</topic><topic>Receptors, GABA-A - metabolism</topic><topic>Sensory Deprivation - physiology</topic><topic>top-down inputs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Komano-Inoue, Sayaka</creatorcontrib><creatorcontrib>Manabe, Hiroyuki</creatorcontrib><creatorcontrib>Ota, Mizuho</creatorcontrib><creatorcontrib>Kusumoto-Yoshida, Ikue</creatorcontrib><creatorcontrib>Yokoyama, Takeshi K.</creatorcontrib><creatorcontrib>Mori, Kensaku</creatorcontrib><creatorcontrib>Yamaguchi, Masahiro</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>The European journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Komano-Inoue, Sayaka</au><au>Manabe, Hiroyuki</au><au>Ota, Mizuho</au><au>Kusumoto-Yoshida, Ikue</au><au>Yokoyama, Takeshi K.</au><au>Mori, Kensaku</au><au>Yamaguchi, Masahiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Top-down inputs from the olfactory cortex in the postprandial period promote elimination of granule cells in the olfactory bulb</atitle><jtitle>The European journal of neuroscience</jtitle><addtitle>Eur J Neurosci</addtitle><date>2014-09</date><risdate>2014</risdate><volume>40</volume><issue>5</issue><spage>2724</spage><epage>2733</epage><pages>2724-2733</pages><issn>0953-816X</issn><eissn>1460-9568</eissn><abstract>Elimination of granule cells (GCs) in the olfactory bulb (OB) is not a continual event but is promoted during a short time window in the postprandial period, typically with postprandial sleep. However, the neuronal mechanisms for the enhanced GC elimination during the postprandial period are not understood. Here, we addressed the question of whether top‐down inputs of centrifugal axons from the olfactory cortex (OC) during the postprandial period are involved in the enhanced GC elimination in the OB. Electrical stimulation of centrifugal axons from the OC of anesthetized mice increased GC apoptosis. Furthermore, pharmacological suppression of top‐down inputs from the OC to the OB during the postprandial period of freely behaving mice by γ‐aminobutyric acid (GABA)A receptor agonist injection in the OC significantly decreased GC apoptosis. Remarkable apoptotic GC elimination in the sensory‐deprived OB was also suppressed by pharmacological blockade of top‐down inputs. These results indicate that top‐down inputs from the OC to the OB during the postprandial period are the crucial signal promoting GC elimination, and suggest that the life and death decision of GCs in the OB is determined by the interplay between bottom‐up sensory inputs from the external world and top‐down inputs from the OC.
We previously reported that elimination of granule cells in the olfactory bulb is promoted during postprandial period. We here showed that top‐down inputs from the olfactory cortex to the olfactory bulb during postprandial period are the crucial signal promoting granule cell elimination. Life and death of granule cells is likely determined by the interplay between bottom‐up sensory inputs from the external world and top‐down inputs from the olfactory cortex.</abstract><cop>France</cop><pub>Blackwell Publishing Ltd</pub><pmid>25041475</pmid><doi>10.1111/ejn.12679</doi><tpages>10</tpages></addata></record> |
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| subjects | adult neurogenesis Animals apoptosis Apoptosis - drug effects Apoptosis - physiology Axons - drug effects Axons - physiology Catheters, Indwelling Cell Count Electric Stimulation Electrodes, Implanted Electroencephalography GABA-A Receptor Agonists - pharmacology Immunohistochemistry Male mice Mice, Inbred C57BL Muscimol - pharmacology Neurons - drug effects Neurons - physiology olfactory bulb Olfactory Bulb - drug effects Olfactory Bulb - physiology olfactory cortex Olfactory Cortex - drug effects Olfactory Cortex - physiology Olfactory Pathways - drug effects Olfactory Pathways - physiology Postprandial Period - drug effects Postprandial Period - physiology Receptors, GABA-A - metabolism Sensory Deprivation - physiology top-down inputs |
| title | Top-down inputs from the olfactory cortex in the postprandial period promote elimination of granule cells in the olfactory bulb |
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