Contact sensitizer 2,4‐dinitrochlorobenzene is a highly potent human TRPA1 agonist

2,4‐Dinitrochlorobenzene (DNCB) is widely used in human clinical studies and in experimental animal studies to evoke allergic contact dermatitis. 2,4‐Dinitrochlorobenzene is a potent immunogen capable of inducing contact sensitization in all humans exposed. However, the mechanism by which DNCB evoke...

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Veröffentlicht in:	Allergy (Copenhagen) 2014-10, Vol.69 (10), p.1424-1427
Hauptverfasser:	Saarnilehto, M., Chapman, H., Savinko, T., Lindstedt, K., Lauerma, A. I., Koivisto, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	2,4‐dinitrochlorobenzene allergic contact dermatitis Allergies allergy Calcium Channels Chemicals contact hypersensitivity Dermatitis Dermatitis, Allergic Contact - immunology Dinitrochlorobenzene - immunology HEK293 Cells human TRPA1 Humans Irritants - immunology Nerve Tissue Proteins - agonists Patch-Clamp Techniques Toxicology Transient Receptor Potential Channels - agonists TRPA1 Cation Channel
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