Recurrent RHOA mutations in pediatric Burkitt lymphoma treated according to the NHL-BFM protocols

Burkitt lymphoma (BL) is the most frequent B‐cell lymphoma in childhood. Genetically, it is characterized by the presence of an IG‐MYC translocation which is supposed to be an initiating but not sufficient event in Burkitt lymphomagenesis. In a recent whole‐genome sequencing study of four cases, we...

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Veröffentlicht in:	Genes chromosomes & cancer 2014-11, Vol.53 (11), p.911-916
Hauptverfasser:	Rohde, Marius, Richter, Julia, Schlesner, Matthias, Betts, Matthew J., Claviez, Alexander, Bonn, Bettina R., Zimmermann, Martin, Damm-Welk, Christine, Russell, Robert B., Borkhardt, Arndt, Eils, Roland, Hoell, Jessica I., Szczepanowski, Monika, Oschlies, Ilske, Klapper, Wolfram, Burkhardt, Birgit, Siebert, Reiner
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Antineoplastic Combined Chemotherapy Protocols - therapeutic use Asparaginase - therapeutic use Burkitt Lymphoma - genetics Burkitt Lymphoma - pathology Burkitt Lymphoma - therapy Child Child, Preschool Cohort Studies Daunorubicin - therapeutic use Female Humans Lymphoma, B-Cell - genetics Lymphoma, B-Cell - pathology Lymphoma, B-Cell - therapy Male Mutation Pediatrics Prednisone - therapeutic use rhoA GTP-Binding Protein - genetics rhoA GTP-Binding Protein - metabolism Vincristine - therapeutic use
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