Immunotherapy of B‐cell non‐Hodgkin lymphoma by targeting the chemokine receptor CXCR5 in a preclinical mouse model

Bispecific antibodies are promising agents for immunotherapy. Here, we describe a quadroma‐based trifunctional bispecific antibody binding the chemokine receptor CXCR5 and the T‐cell antigen CD3 that efficiently prevents tumor growth in a mouse B‐cell lymphoma model. CXCR5 regulates the tissue homeo...

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Veröffentlicht in:	International journal of cancer 2014-12, Vol.135 (11), p.2623-2632
Hauptverfasser:	Panjideh, Hossein, Müller, Gerd, Koch, Mathias, Wilde, Frank, Scheu, Susanne, Moldenhauer, Gerhard, Lipp, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Bispecific - immunology Antibodies, Bispecific - therapeutic use B-Lymphocytes - immunology B-Lymphocytes - metabolism B-Lymphocytes - pathology Bispecific antibodies bispecific antibody Cancer CD25 antigen CD3 CD3 antigen CD3 Complex - chemistry CD3 Complex - immunology CD4 antigen CD69 antigen CD8 antigen Cell activation chemokine receptor Chemokines CXCR5 CXCR5 protein Cytotoxicity Disease Models, Animal Effector cells Female Helper cells Homeostasis Humans Immune system Immunotherapy Interferon Leukocytes (mononuclear) Lymphocytes Lymphocytes B Lymphocytes T Lymphoma Lymphoma, B-Cell - immunology Lymphoma, B-Cell - mortality Lymphoma, B-Cell - therapy Medical research Mice Mice, Inbred NOD Mice, SCID Monoclonal antibodies Non-Hodgkin's lymphoma non‐Hodgkin lymphoma Peripheral blood mononuclear cells Receptors, CXCR5 - antagonists & inhibitors Receptors, CXCR5 - immunology Rituximab Secretion Survival Rate T-Lymphocytes - immunology T-Lymphocytes - metabolism T-Lymphocytes - pathology Targeted cancer therapy Transplantation, Heterologous Tumor Cells, Cultured Tumor necrosis factor Xenografts
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