Ploidy and Large-Scale Genomic Instability Consistently Identify Basal-like Breast Carcinomas with BRCA1/2 Inactivation

BRCA1 inactivation is a frequent event in basal-like breast carcinomas (BLC). However, BRCA1 can be inactivated by multiple mechanisms and determining its status is not a trivial issue. As an alternate approach, we profiled 65 BLC cases using single-nucleotide polymorphism arrays to define a signatu...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2012-11, Vol.72 (21), p.5454-5462
Hauptverfasser:	POPOVA, Tatiana, MANIE, Elodie, HOUDAYE, Claude, SASTRE-GARAU, Xavier, VINCENT-SALOMON, Anne, STOPPA-LYONNET, Dominique, STERN, Marc-Henri, RIEUNIER, Guillaume, CAUX-MONCOUTIER, Virginie, TIRAPO, Carole, DUBOIS, Thierry, DELATTRE, Olivier, SIGAL-ZAFRANI, Brigitte, BOLLET, Marc, LONGY, Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - pathology Antineoplastic agents Biological and medical sciences Breast Neoplasms - genetics Breast Neoplasms - pathology Carcinoma, Ductal, Breast - genetics Carcinoma, Ductal, Breast - pathology Female Fluorescent Antibody Technique Genes, BRCA1 Genes, BRCA2 Genetic Testing - methods Genomic Instability Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Pharmacology. Drug treatments Ploidies Polymerase Chain Reaction Polymorphism, Single Nucleotide Sensitivity and Specificity Tumors
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