Urinary 1-hydroxypyrene as a comprehensive carcinogenic biomarker of exposure to polycyclic aromatic hydrocarbons: a cross-sectional study of coke oven workers in China
Purpose Polycyclic aromatic hydrocarbons (PAHs) are multiple compounds that include many carcinogens. We conducted a cross-sectional study in steel plant workers in Anshan, China, to identify biomarkers that reflect the carcinogenicity of PAHs. Methods Subjects were 57 workers and 20 controls. Level...
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| Veröffentlicht in: | International archives of occupational and environmental health 2014-10, Vol.87 (7), p.705-713 |
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| creator | Yamano, Yuko Hara, Kunio Ichiba, Masayoshi Hanaoka, Tomoyuki Pan, Guowei Nakadate, Toshio |
| description | Purpose
Polycyclic aromatic hydrocarbons (PAHs) are multiple compounds that include many carcinogens. We conducted a cross-sectional study in steel plant workers in Anshan, China, to identify biomarkers that reflect the carcinogenicity of PAHs.
Methods
Subjects were 57 workers and 20 controls. Level of personal exposure to PAHs was measured using GC–MS. In accordance with the assessment methods defined by the United States Environmental Protection Agency (US EPA), 15 PAHs were selected for the analysis. For the measurement of urinary metabolites, urine samples were treated with β-glucuronidase and analyzed using HPLC with a fluorescence detector.
Results
The mean range of personal exposure to 15 PAHs (total PAHs) was 178.85, 47.08–1,329.45 (geometric mean, 5th and 95th percentile) μg/m
3
. Ten known urinary metabolites (1-hydroxynaphthalene, 2-hydroxynaphthalene, 2-hydroxyfluorene, 1-hydroxyphenanthrene, 3-hydroxyphenanthrene, 9-hydroxyphenanthrene, 1-hydroxypyrene, 3-hydroxybenz[a]anthracene, 6-hydroxychrysene, and 3-hydroxybenzo[a]pyrene) and four unknown peaks were detected. The highest correlation was between total PAHs and urinary 2-hydroxynaphthalene (Spearman
r
= 0.716,
P
|
| doi_str_mv | 10.1007/s00420-013-0913-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1566842339</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3429657801</sourcerecordid><originalsourceid>FETCH-LOGICAL-c501t-de7de701e62f5bf0ab6b254ed4d0f132e0ac6dd83e24856ce7c2733954c2c5a83</originalsourceid><addsrcrecordid>eNp1kdtu1DAQhi0EotvCA3CDLCGk3qT4nCx31YqTVIkbeh05zqTrNmsHT1KaN-IxcXYXqJCQLNvSfPPP4SfkFWcXnLHyHTKmBCsYlwVb58s8ISuupCi4UOYpWTGp9lF-Qk4RbxnjpSnlc3IiFBeCrfWK_LxOPtg0U15s5zbFh3mYEwSgFqmlLu6GBFsI6O-BOpucD_EGgne08XFn0x0kGjsKD0PEKQEdIx1iP7vZ9ZmxKTNj_uylc3oTA75fdFNELBDc6GOwPcVxaudFyMU7oPEeAv0RF3GkPtDNNrf4gjzrbI_w8viekeuPH75tPhdXXz992VxeFU4zPhYtlPkwDkZ0uumYbUwjtIJWtazjUgCzzrRtJUGoShsHpROllGutnHDaVvKMnB90hxS_T4BjvfPooO9tgDhhzbUxlRI5JaNv_kFv45TyPHuKK1HmPWeKH6j90Am6ekg-r26uOasXG-uDjXU2ql5srE3OeX1UnpodtH8yfvuWgbdHwKKzfZdscB7_clVZrbVeiosDhzkUbiA9avG_1X8B6pS4aw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1561427241</pqid></control><display><type>article</type><title>Urinary 1-hydroxypyrene as a comprehensive carcinogenic biomarker of exposure to polycyclic aromatic hydrocarbons: a cross-sectional study of coke oven workers in China</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Yamano, Yuko ; Hara, Kunio ; Ichiba, Masayoshi ; Hanaoka, Tomoyuki ; Pan, Guowei ; Nakadate, Toshio</creator><creatorcontrib>Yamano, Yuko ; Hara, Kunio ; Ichiba, Masayoshi ; Hanaoka, Tomoyuki ; Pan, Guowei ; Nakadate, Toshio</creatorcontrib><description>Purpose
Polycyclic aromatic hydrocarbons (PAHs) are multiple compounds that include many carcinogens. We conducted a cross-sectional study in steel plant workers in Anshan, China, to identify biomarkers that reflect the carcinogenicity of PAHs.
Methods
Subjects were 57 workers and 20 controls. Level of personal exposure to PAHs was measured using GC–MS. In accordance with the assessment methods defined by the United States Environmental Protection Agency (US EPA), 15 PAHs were selected for the analysis. For the measurement of urinary metabolites, urine samples were treated with β-glucuronidase and analyzed using HPLC with a fluorescence detector.
Results
The mean range of personal exposure to 15 PAHs (total PAHs) was 178.85, 47.08–1,329.45 (geometric mean, 5th and 95th percentile) μg/m
3
. Ten known urinary metabolites (1-hydroxynaphthalene, 2-hydroxynaphthalene, 2-hydroxyfluorene, 1-hydroxyphenanthrene, 3-hydroxyphenanthrene, 9-hydroxyphenanthrene, 1-hydroxypyrene, 3-hydroxybenz[a]anthracene, 6-hydroxychrysene, and 3-hydroxybenzo[a]pyrene) and four unknown peaks were detected. The highest correlation was between total PAHs and urinary 2-hydroxynaphthalene (Spearman
r
= 0.716,
P
< 0.01). Among the detected urinary metabolites, 2-hydroxyfluorene, 1-hydroxyphenanthrene, 3-hydroxyphenanthrene, and 1-hydroxypyrene were found to correlate significantly with the “Σ carcinogenic potency of PAHs” (sum of seven carcinogenic PAHs calculated from the levels of personal PAHs and relative potency factors), and with the greatest correlation found for 1-hydroxypyrene (Spearman
r
= 0.630,
P
< 0.01).
Conclusions
The analysis of personal exposure to 15 PAHs and 10 urinary metabolites, and calculation of Σ carcinogenic potency, indicated that urinary 1-hydroxypyrene was the most comprehensive carcinogenic biomarker of exposure to PAHs.</description><identifier>ISSN: 0340-0131</identifier><identifier>EISSN: 1432-1246</identifier><identifier>DOI: 10.1007/s00420-013-0913-6</identifier><identifier>PMID: 24122095</identifier><identifier>CODEN: IAEHDW</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Air Pollutants, Occupational - analysis ; Anthracene ; Biological and medical sciences ; Biomarkers ; Carcinogenesis, carcinogens and anticarcinogens ; Carcinogenicity ; Carcinogens - analysis ; Chemical agents ; China ; Coke ; Cross-Sectional Studies ; Earth and Environmental Science ; Environment ; Environmental Health ; Environmental Monitoring ; Environmental protection ; Exposure ; Female ; Gas Chromatography-Mass Spectrometry ; Human exposure ; Humans ; Liquid chromatography ; Male ; Medical sciences ; Metabolites ; Middle Aged ; Occupational Exposure - analysis ; Occupational health ; Occupational medicine ; Occupational Medicine/Industrial Medicine ; Original Article ; Polycyclic aromatic hydrocarbons ; Polycyclic Aromatic Hydrocarbons - analysis ; Public health. Hygiene-occupational medicine ; Pyrenes - urine ; Rehabilitation ; Smoking - epidemiology ; Tumors</subject><ispartof>International archives of occupational and environmental health, 2014-10, Vol.87 (7), p.705-713</ispartof><rights>Springer-Verlag Berlin Heidelberg 2013</rights><rights>2015 INIST-CNRS</rights><rights>Springer-Verlag Berlin Heidelberg 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c501t-de7de701e62f5bf0ab6b254ed4d0f132e0ac6dd83e24856ce7c2733954c2c5a83</citedby><cites>FETCH-LOGICAL-c501t-de7de701e62f5bf0ab6b254ed4d0f132e0ac6dd83e24856ce7c2733954c2c5a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00420-013-0913-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00420-013-0913-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28789551$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24122095$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamano, Yuko</creatorcontrib><creatorcontrib>Hara, Kunio</creatorcontrib><creatorcontrib>Ichiba, Masayoshi</creatorcontrib><creatorcontrib>Hanaoka, Tomoyuki</creatorcontrib><creatorcontrib>Pan, Guowei</creatorcontrib><creatorcontrib>Nakadate, Toshio</creatorcontrib><title>Urinary 1-hydroxypyrene as a comprehensive carcinogenic biomarker of exposure to polycyclic aromatic hydrocarbons: a cross-sectional study of coke oven workers in China</title><title>International archives of occupational and environmental health</title><addtitle>Int Arch Occup Environ Health</addtitle><addtitle>Int Arch Occup Environ Health</addtitle><description>Purpose
Polycyclic aromatic hydrocarbons (PAHs) are multiple compounds that include many carcinogens. We conducted a cross-sectional study in steel plant workers in Anshan, China, to identify biomarkers that reflect the carcinogenicity of PAHs.
Methods
Subjects were 57 workers and 20 controls. Level of personal exposure to PAHs was measured using GC–MS. In accordance with the assessment methods defined by the United States Environmental Protection Agency (US EPA), 15 PAHs were selected for the analysis. For the measurement of urinary metabolites, urine samples were treated with β-glucuronidase and analyzed using HPLC with a fluorescence detector.
Results
The mean range of personal exposure to 15 PAHs (total PAHs) was 178.85, 47.08–1,329.45 (geometric mean, 5th and 95th percentile) μg/m
3
. Ten known urinary metabolites (1-hydroxynaphthalene, 2-hydroxynaphthalene, 2-hydroxyfluorene, 1-hydroxyphenanthrene, 3-hydroxyphenanthrene, 9-hydroxyphenanthrene, 1-hydroxypyrene, 3-hydroxybenz[a]anthracene, 6-hydroxychrysene, and 3-hydroxybenzo[a]pyrene) and four unknown peaks were detected. The highest correlation was between total PAHs and urinary 2-hydroxynaphthalene (Spearman
r
= 0.716,
P
< 0.01). Among the detected urinary metabolites, 2-hydroxyfluorene, 1-hydroxyphenanthrene, 3-hydroxyphenanthrene, and 1-hydroxypyrene were found to correlate significantly with the “Σ carcinogenic potency of PAHs” (sum of seven carcinogenic PAHs calculated from the levels of personal PAHs and relative potency factors), and with the greatest correlation found for 1-hydroxypyrene (Spearman
r
= 0.630,
P
< 0.01).
Conclusions
The analysis of personal exposure to 15 PAHs and 10 urinary metabolites, and calculation of Σ carcinogenic potency, indicated that urinary 1-hydroxypyrene was the most comprehensive carcinogenic biomarker of exposure to PAHs.</description><subject>Adult</subject><subject>Air Pollutants, Occupational - analysis</subject><subject>Anthracene</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Carcinogenicity</subject><subject>Carcinogens - analysis</subject><subject>Chemical agents</subject><subject>China</subject><subject>Coke</subject><subject>Cross-Sectional Studies</subject><subject>Earth and Environmental Science</subject><subject>Environment</subject><subject>Environmental Health</subject><subject>Environmental Monitoring</subject><subject>Environmental protection</subject><subject>Exposure</subject><subject>Female</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>Human exposure</subject><subject>Humans</subject><subject>Liquid chromatography</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolites</subject><subject>Middle Aged</subject><subject>Occupational Exposure - analysis</subject><subject>Occupational health</subject><subject>Occupational medicine</subject><subject>Occupational Medicine/Industrial Medicine</subject><subject>Original Article</subject><subject>Polycyclic aromatic hydrocarbons</subject><subject>Polycyclic Aromatic Hydrocarbons - analysis</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Pyrenes - urine</subject><subject>Rehabilitation</subject><subject>Smoking - epidemiology</subject><subject>Tumors</subject><issn>0340-0131</issn><issn>1432-1246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kdtu1DAQhi0EotvCA3CDLCGk3qT4nCx31YqTVIkbeh05zqTrNmsHT1KaN-IxcXYXqJCQLNvSfPPP4SfkFWcXnLHyHTKmBCsYlwVb58s8ISuupCi4UOYpWTGp9lF-Qk4RbxnjpSnlc3IiFBeCrfWK_LxOPtg0U15s5zbFh3mYEwSgFqmlLu6GBFsI6O-BOpucD_EGgne08XFn0x0kGjsKD0PEKQEdIx1iP7vZ9ZmxKTNj_uylc3oTA75fdFNELBDc6GOwPcVxaudFyMU7oPEeAv0RF3GkPtDNNrf4gjzrbI_w8viekeuPH75tPhdXXz992VxeFU4zPhYtlPkwDkZ0uumYbUwjtIJWtazjUgCzzrRtJUGoShsHpROllGutnHDaVvKMnB90hxS_T4BjvfPooO9tgDhhzbUxlRI5JaNv_kFv45TyPHuKK1HmPWeKH6j90Am6ekg-r26uOasXG-uDjXU2ql5srE3OeX1UnpodtH8yfvuWgbdHwKKzfZdscB7_clVZrbVeiosDhzkUbiA9avG_1X8B6pS4aw</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Yamano, Yuko</creator><creator>Hara, Kunio</creator><creator>Ichiba, Masayoshi</creator><creator>Hanaoka, Tomoyuki</creator><creator>Pan, Guowei</creator><creator>Nakadate, Toshio</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7T5</scope><scope>7TM</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>7U2</scope></search><sort><creationdate>20141001</creationdate><title>Urinary 1-hydroxypyrene as a comprehensive carcinogenic biomarker of exposure to polycyclic aromatic hydrocarbons: a cross-sectional study of coke oven workers in China</title><author>Yamano, Yuko ; Hara, Kunio ; Ichiba, Masayoshi ; Hanaoka, Tomoyuki ; Pan, Guowei ; Nakadate, Toshio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c501t-de7de701e62f5bf0ab6b254ed4d0f132e0ac6dd83e24856ce7c2733954c2c5a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Air Pollutants, Occupational - analysis</topic><topic>Anthracene</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Carcinogenicity</topic><topic>Carcinogens - analysis</topic><topic>Chemical agents</topic><topic>China</topic><topic>Coke</topic><topic>Cross-Sectional Studies</topic><topic>Earth and Environmental Science</topic><topic>Environment</topic><topic>Environmental Health</topic><topic>Environmental Monitoring</topic><topic>Environmental protection</topic><topic>Exposure</topic><topic>Female</topic><topic>Gas Chromatography-Mass Spectrometry</topic><topic>Human exposure</topic><topic>Humans</topic><topic>Liquid chromatography</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolites</topic><topic>Middle Aged</topic><topic>Occupational Exposure - analysis</topic><topic>Occupational health</topic><topic>Occupational medicine</topic><topic>Occupational Medicine/Industrial Medicine</topic><topic>Original Article</topic><topic>Polycyclic aromatic hydrocarbons</topic><topic>Polycyclic Aromatic Hydrocarbons - analysis</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Pyrenes - urine</topic><topic>Rehabilitation</topic><topic>Smoking - epidemiology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamano, Yuko</creatorcontrib><creatorcontrib>Hara, Kunio</creatorcontrib><creatorcontrib>Ichiba, Masayoshi</creatorcontrib><creatorcontrib>Hanaoka, Tomoyuki</creatorcontrib><creatorcontrib>Pan, Guowei</creatorcontrib><creatorcontrib>Nakadate, Toshio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>Safety Science and Risk</collection><jtitle>International archives of occupational and environmental health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamano, Yuko</au><au>Hara, Kunio</au><au>Ichiba, Masayoshi</au><au>Hanaoka, Tomoyuki</au><au>Pan, Guowei</au><au>Nakadate, Toshio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary 1-hydroxypyrene as a comprehensive carcinogenic biomarker of exposure to polycyclic aromatic hydrocarbons: a cross-sectional study of coke oven workers in China</atitle><jtitle>International archives of occupational and environmental health</jtitle><stitle>Int Arch Occup Environ Health</stitle><addtitle>Int Arch Occup Environ Health</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>87</volume><issue>7</issue><spage>705</spage><epage>713</epage><pages>705-713</pages><issn>0340-0131</issn><eissn>1432-1246</eissn><coden>IAEHDW</coden><abstract>Purpose
Polycyclic aromatic hydrocarbons (PAHs) are multiple compounds that include many carcinogens. We conducted a cross-sectional study in steel plant workers in Anshan, China, to identify biomarkers that reflect the carcinogenicity of PAHs.
Methods
Subjects were 57 workers and 20 controls. Level of personal exposure to PAHs was measured using GC–MS. In accordance with the assessment methods defined by the United States Environmental Protection Agency (US EPA), 15 PAHs were selected for the analysis. For the measurement of urinary metabolites, urine samples were treated with β-glucuronidase and analyzed using HPLC with a fluorescence detector.
Results
The mean range of personal exposure to 15 PAHs (total PAHs) was 178.85, 47.08–1,329.45 (geometric mean, 5th and 95th percentile) μg/m
3
. Ten known urinary metabolites (1-hydroxynaphthalene, 2-hydroxynaphthalene, 2-hydroxyfluorene, 1-hydroxyphenanthrene, 3-hydroxyphenanthrene, 9-hydroxyphenanthrene, 1-hydroxypyrene, 3-hydroxybenz[a]anthracene, 6-hydroxychrysene, and 3-hydroxybenzo[a]pyrene) and four unknown peaks were detected. The highest correlation was between total PAHs and urinary 2-hydroxynaphthalene (Spearman
r
= 0.716,
P
< 0.01). Among the detected urinary metabolites, 2-hydroxyfluorene, 1-hydroxyphenanthrene, 3-hydroxyphenanthrene, and 1-hydroxypyrene were found to correlate significantly with the “Σ carcinogenic potency of PAHs” (sum of seven carcinogenic PAHs calculated from the levels of personal PAHs and relative potency factors), and with the greatest correlation found for 1-hydroxypyrene (Spearman
r
= 0.630,
P
< 0.01).
Conclusions
The analysis of personal exposure to 15 PAHs and 10 urinary metabolites, and calculation of Σ carcinogenic potency, indicated that urinary 1-hydroxypyrene was the most comprehensive carcinogenic biomarker of exposure to PAHs.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>24122095</pmid><doi>10.1007/s00420-013-0913-6</doi><tpages>9</tpages></addata></record> |
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| ispartof | International archives of occupational and environmental health, 2014-10, Vol.87 (7), p.705-713 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Air Pollutants, Occupational - analysis Anthracene Biological and medical sciences Biomarkers Carcinogenesis, carcinogens and anticarcinogens Carcinogenicity Carcinogens - analysis Chemical agents China Coke Cross-Sectional Studies Earth and Environmental Science Environment Environmental Health Environmental Monitoring Environmental protection Exposure Female Gas Chromatography-Mass Spectrometry Human exposure Humans Liquid chromatography Male Medical sciences Metabolites Middle Aged Occupational Exposure - analysis Occupational health Occupational medicine Occupational Medicine/Industrial Medicine Original Article Polycyclic aromatic hydrocarbons Polycyclic Aromatic Hydrocarbons - analysis Public health. Hygiene-occupational medicine Pyrenes - urine Rehabilitation Smoking - epidemiology Tumors |
| title | Urinary 1-hydroxypyrene as a comprehensive carcinogenic biomarker of exposure to polycyclic aromatic hydrocarbons: a cross-sectional study of coke oven workers in China |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T20%3A48%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Urinary%201-hydroxypyrene%20as%20a%20comprehensive%20carcinogenic%20biomarker%20of%20exposure%20to%20polycyclic%20aromatic%20hydrocarbons:%20a%20cross-sectional%20study%20of%20coke%20oven%20workers%20in%20China&rft.jtitle=International%20archives%20of%20occupational%20and%20environmental%20health&rft.au=Yamano,%20Yuko&rft.date=2014-10-01&rft.volume=87&rft.issue=7&rft.spage=705&rft.epage=713&rft.pages=705-713&rft.issn=0340-0131&rft.eissn=1432-1246&rft.coden=IAEHDW&rft_id=info:doi/10.1007/s00420-013-0913-6&rft_dat=%3Cproquest_cross%3E3429657801%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1561427241&rft_id=info:pmid/24122095&rfr_iscdi=true |