Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes

Background Airway inflammation is associated with asthma exacerbation risk, treatment response, and disease mechanisms. Objective This study aimed to identify and validate a sputum gene expression signature that discriminates asthma inflammatory phenotypes. Methods An asthma phenotype biomarker disc...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2014-04, Vol.133 (4), p.997-1007
Hauptverfasser:	Baines, Katherine J., PhD, Simpson, Jodie L., PhD, Wood, Lisa G., PhD, Scott, Rodney J., PhD, Fibbens, Naomi L., DipPathTech, Powell, Heather, MMedSci, Cowan, Douglas C., PhD, Taylor, D. Robin, DSc, Cowan, Jan O, Gibson, Peter G., MBBS
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Adrenal Cortex Hormones - administration & dosage Adrenal Cortex Hormones - therapeutic use Adult Aged Allergy and Immunology Ambulatory care Asthma Asthma - diagnosis Asthma - drug therapy Asthma - genetics Biological and medical sciences Biomarkers Case-Control Studies Chronic obstructive pulmonary disease, asthma Disease eosinophils Ethics Female Fundamental and applied biological sciences. Psychology Fundamental immunology Gene expression Gene Expression Profiling Genotype & phenotype Humans Immunopathology induced sputum Inflammation - diagnosis Inflammation - genetics inflammatory phenotypes Male Medical sciences Middle Aged neutrophils Phenotype Pneumology Population Reproducibility of Results ROC Curve Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Sputum - metabolism Transcriptome Young Adult
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