Costimulation of IL-4 production by murine B7-1 and B7-2 molecules

We have examined the capacity of murine B7-1 and B7-2 to costimulate the production of IL-4 by murine CD4+ T lymphocytes. Cloned and freshly isolated T cells were incubated with the anti-CD3 mAb 145-2C11 in the presence of Chinese hamster ovary (CHO) cells that stably express murine B7-1 and B7-2 at...

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Veröffentlicht in:	The Journal of immunology (1950) 1996-04, Vol.156 (8), p.2783-2791
Hauptverfasser:	Natesan, M, Razi-Wolf, Z, Reiser, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - genetics Antigens, CD - pharmacology B7-1 Antigen - genetics B7-1 Antigen - pharmacology B7-2 Antigen Base Sequence CD4-Positive T-Lymphocytes - classification CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - metabolism CHO Cells Clone Cells Cricetinae Drug Synergism Hyaluronan Receptors - analysis Interferon-gamma - biosynthesis Interferon-gamma - genetics Interleukin-4 - biosynthesis Interleukin-4 - genetics Lymphocyte Activation - drug effects Membrane Glycoproteins - genetics Membrane Glycoproteins - pharmacology Mice Mice, Inbred BALB C Molecular Sequence Data RNA, Messenger - isolation & purification Transfection - immunology
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