Reproductive toxicity of lead, cadmium, and phthalate exposure in men
Environmental toxicants viz lead or cadmium and phthalate esters (di(2-ethylhexyl) phthalate [DEHP], dibutyl phthalate [DBP], and diethyl phthalate [DEP]) widely found in different environmental strata are linked to deteriorating male reproductive health. The objective was to assess the relationship...
Gespeichert in:
| Veröffentlicht in: | Environmental science and pollution research international 2014-09, Vol.21 (18), p.11066-11074 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 11074 |
|---|---|
| container_issue | 18 |
| container_start_page | 11066 |
| container_title | Environmental science and pollution research international |
| container_volume | 21 |
| creator | Pant, Niraj Kumar, G Upadhyay, A. D Patel, D. K Gupta, Y. K Chaturvedi, P. K |
| description | Environmental toxicants viz lead or cadmium and phthalate esters (di(2-ethylhexyl) phthalate [DEHP], dibutyl phthalate [DBP], and diethyl phthalate [DEP]) widely found in different environmental strata are linked to deteriorating male reproductive health. The objective was to assess the relationships between the seminal lead, cadmium, and phthalate (DEHP, DBP, DEP) concentrations at environmental level and serum hormone levels and semen quality in non-occupationally exposed men and specify the effect of individual and combined exposure of toxicants on semen quality. A study of 60 male partners of couples attending the Andrology Laboratory of the Reproductive Biology Department, All India Institute of Medical Sciences (AIIMS), New Delhi, India for semen analysis to assess their inability to achieve a pregnancy was selected for the study. The results of univariate and stepwise multiple regression analysis in the unadjusted model showed a significant correlation between lead or cadmium and phthalates DEHP/DBP/DEP and sperm motility, sperm concentration, and DNA damage. After adjusting for potential confounders, an association with lead or DEHP was only observed. The present data shows that lead (Pb) or cadmium (Cd) or phthalates might independently contribute to decline in semen quality and induce DNA damage. Phthalates might influence reproductive hormone testosterone. These findings are significant in light of the fact that men are exposed to a volley of chemicals; however, due to the small sample size, our finding needs to be confirmed in a larger population. |
| doi_str_mv | 10.1007/s11356-014-2986-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1566841520</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4054899301</sourcerecordid><originalsourceid>FETCH-LOGICAL-c540t-d5bd59c3f04eec7f7df21d692855b2fab2893351cc5301c36cae3d2db700bb43</originalsourceid><addsrcrecordid>eNp9kE1LHjEUhUOp1Le2P8BNG-imC6fefE6yFNEqCEK165BJ7ujIfLxNZor-eyNji7hwFUKec3J4CNln8IMB1IeZMaF0BUxW3BpdqXdkw3S51dLa92QDVsqKCSl3ycec7wA4WF5_ILtcGqalFhty8gu3aYpLmLu_SOfpvgvd_ECnlvbo4wENPg7dMhxQP0a6vZ1vfe9npHi_nfKSkHYjHXD8RHZa32f8_HzukevTk-vjs-ri8uf58dFFFZSEuYqqicoG0YJEDHVbx5azqC03SjW89Q03VgjFQlACWBA6eBSRx6YGaBop9sj3tbZM_rNgnt3Q5YB970ecluyY0tpIpjgU9Nsr9G5a0ljGOVYbo6wypi4UW6mQppwTtm6busGnB8fAPSl2q2JXFLsnxU6VzJfn5qUZMP5P_HNaAL4CuTyNN5hefP1G69c11PrJ-ZvUZff7ihcAgIkyFsQjBheOyQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1788595887</pqid></control><display><type>article</type><title>Reproductive toxicity of lead, cadmium, and phthalate exposure in men</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Pant, Niraj ; Kumar, G ; Upadhyay, A. D ; Patel, D. K ; Gupta, Y. K ; Chaturvedi, P. K</creator><creatorcontrib>Pant, Niraj ; Kumar, G ; Upadhyay, A. D ; Patel, D. K ; Gupta, Y. K ; Chaturvedi, P. K</creatorcontrib><description>Environmental toxicants viz lead or cadmium and phthalate esters (di(2-ethylhexyl) phthalate [DEHP], dibutyl phthalate [DBP], and diethyl phthalate [DEP]) widely found in different environmental strata are linked to deteriorating male reproductive health. The objective was to assess the relationships between the seminal lead, cadmium, and phthalate (DEHP, DBP, DEP) concentrations at environmental level and serum hormone levels and semen quality in non-occupationally exposed men and specify the effect of individual and combined exposure of toxicants on semen quality. A study of 60 male partners of couples attending the Andrology Laboratory of the Reproductive Biology Department, All India Institute of Medical Sciences (AIIMS), New Delhi, India for semen analysis to assess their inability to achieve a pregnancy was selected for the study. The results of univariate and stepwise multiple regression analysis in the unadjusted model showed a significant correlation between lead or cadmium and phthalates DEHP/DBP/DEP and sperm motility, sperm concentration, and DNA damage. After adjusting for potential confounders, an association with lead or DEHP was only observed. The present data shows that lead (Pb) or cadmium (Cd) or phthalates might independently contribute to decline in semen quality and induce DNA damage. Phthalates might influence reproductive hormone testosterone. These findings are significant in light of the fact that men are exposed to a volley of chemicals; however, due to the small sample size, our finding needs to be confirmed in a larger population.</description><identifier>ISSN: 0944-1344</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-014-2986-5</identifier><identifier>PMID: 24816463</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Abstinence ; Adult ; Aquatic Pollution ; Atmospheric Protection/Air Quality Control/Air Pollution ; Biology ; Bis(2-ethylhexyl) phthalate ; blood serum ; Cadmium ; Cadmium - metabolism ; Cadmium - toxicity ; Deoxyribonucleic acid ; dibutyl phthalate ; Diethyl phthalate ; DNA ; DNA Damage ; Earth and Environmental Science ; Ecotoxicology ; Environment ; Environmental Chemistry ; Environmental Exposure ; Environmental Health ; Environmental Pollutants - metabolism ; Environmental Pollutants - toxicity ; Esters ; Food contamination & poisoning ; Heavy metals ; Hormones ; Humans ; Infertility, Male - chemically induced ; Laboratories ; Lead ; Lead - metabolism ; Lead - toxicity ; Male ; men ; Motility ; Multiple regression analysis ; Occupational exposure ; Phthalate esters ; Phthalates ; Phthalic Acids - metabolism ; Phthalic Acids - toxicity ; pregnancy ; Quality ; regression analysis ; Reproductive health ; reproductive toxicology ; Research Article ; Semen ; Semen - metabolism ; Semen Analysis ; Sperm ; sperm concentration ; Sperm Count ; sperm motility ; Sperm Motility - drug effects ; Testosterone ; Testosterone - metabolism ; toxic substances ; Toxicants ; Toxicity ; Waste Water Technology ; Water Management ; Water Pollution Control ; Young Adult</subject><ispartof>Environmental science and pollution research international, 2014-09, Vol.21 (18), p.11066-11074</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-d5bd59c3f04eec7f7df21d692855b2fab2893351cc5301c36cae3d2db700bb43</citedby><cites>FETCH-LOGICAL-c540t-d5bd59c3f04eec7f7df21d692855b2fab2893351cc5301c36cae3d2db700bb43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11356-014-2986-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11356-014-2986-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24816463$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pant, Niraj</creatorcontrib><creatorcontrib>Kumar, G</creatorcontrib><creatorcontrib>Upadhyay, A. D</creatorcontrib><creatorcontrib>Patel, D. K</creatorcontrib><creatorcontrib>Gupta, Y. K</creatorcontrib><creatorcontrib>Chaturvedi, P. K</creatorcontrib><title>Reproductive toxicity of lead, cadmium, and phthalate exposure in men</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><addtitle>Environ Sci Pollut Res Int</addtitle><description>Environmental toxicants viz lead or cadmium and phthalate esters (di(2-ethylhexyl) phthalate [DEHP], dibutyl phthalate [DBP], and diethyl phthalate [DEP]) widely found in different environmental strata are linked to deteriorating male reproductive health. The objective was to assess the relationships between the seminal lead, cadmium, and phthalate (DEHP, DBP, DEP) concentrations at environmental level and serum hormone levels and semen quality in non-occupationally exposed men and specify the effect of individual and combined exposure of toxicants on semen quality. A study of 60 male partners of couples attending the Andrology Laboratory of the Reproductive Biology Department, All India Institute of Medical Sciences (AIIMS), New Delhi, India for semen analysis to assess their inability to achieve a pregnancy was selected for the study. The results of univariate and stepwise multiple regression analysis in the unadjusted model showed a significant correlation between lead or cadmium and phthalates DEHP/DBP/DEP and sperm motility, sperm concentration, and DNA damage. After adjusting for potential confounders, an association with lead or DEHP was only observed. The present data shows that lead (Pb) or cadmium (Cd) or phthalates might independently contribute to decline in semen quality and induce DNA damage. Phthalates might influence reproductive hormone testosterone. These findings are significant in light of the fact that men are exposed to a volley of chemicals; however, due to the small sample size, our finding needs to be confirmed in a larger population.</description><subject>Abstinence</subject><subject>Adult</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Biology</subject><subject>Bis(2-ethylhexyl) phthalate</subject><subject>blood serum</subject><subject>Cadmium</subject><subject>Cadmium - metabolism</subject><subject>Cadmium - toxicity</subject><subject>Deoxyribonucleic acid</subject><subject>dibutyl phthalate</subject><subject>Diethyl phthalate</subject><subject>DNA</subject><subject>DNA Damage</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Exposure</subject><subject>Environmental Health</subject><subject>Environmental Pollutants - metabolism</subject><subject>Environmental Pollutants - toxicity</subject><subject>Esters</subject><subject>Food contamination & poisoning</subject><subject>Heavy metals</subject><subject>Hormones</subject><subject>Humans</subject><subject>Infertility, Male - chemically induced</subject><subject>Laboratories</subject><subject>Lead</subject><subject>Lead - metabolism</subject><subject>Lead - toxicity</subject><subject>Male</subject><subject>men</subject><subject>Motility</subject><subject>Multiple regression analysis</subject><subject>Occupational exposure</subject><subject>Phthalate esters</subject><subject>Phthalates</subject><subject>Phthalic Acids - metabolism</subject><subject>Phthalic Acids - toxicity</subject><subject>pregnancy</subject><subject>Quality</subject><subject>regression analysis</subject><subject>Reproductive health</subject><subject>reproductive toxicology</subject><subject>Research Article</subject><subject>Semen</subject><subject>Semen - metabolism</subject><subject>Semen Analysis</subject><subject>Sperm</subject><subject>sperm concentration</subject><subject>Sperm Count</subject><subject>sperm motility</subject><subject>Sperm Motility - drug effects</subject><subject>Testosterone</subject><subject>Testosterone - metabolism</subject><subject>toxic substances</subject><subject>Toxicants</subject><subject>Toxicity</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution Control</subject><subject>Young Adult</subject><issn>0944-1344</issn><issn>1614-7499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kE1LHjEUhUOp1Le2P8BNG-imC6fefE6yFNEqCEK165BJ7ujIfLxNZor-eyNji7hwFUKec3J4CNln8IMB1IeZMaF0BUxW3BpdqXdkw3S51dLa92QDVsqKCSl3ycec7wA4WF5_ILtcGqalFhty8gu3aYpLmLu_SOfpvgvd_ECnlvbo4wENPg7dMhxQP0a6vZ1vfe9npHi_nfKSkHYjHXD8RHZa32f8_HzukevTk-vjs-ri8uf58dFFFZSEuYqqicoG0YJEDHVbx5azqC03SjW89Q03VgjFQlACWBA6eBSRx6YGaBop9sj3tbZM_rNgnt3Q5YB970ecluyY0tpIpjgU9Nsr9G5a0ljGOVYbo6wypi4UW6mQppwTtm6busGnB8fAPSl2q2JXFLsnxU6VzJfn5qUZMP5P_HNaAL4CuTyNN5hefP1G69c11PrJ-ZvUZff7ihcAgIkyFsQjBheOyQ</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Pant, Niraj</creator><creator>Kumar, G</creator><creator>Upadhyay, A. D</creator><creator>Patel, D. K</creator><creator>Gupta, Y. K</creator><creator>Chaturvedi, P. K</creator><general>Springer-Verlag</general><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7SN</scope><scope>7T7</scope><scope>7TV</scope><scope>7U7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>P64</scope><scope>PATMY</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>7ST</scope><scope>SOI</scope></search><sort><creationdate>20140901</creationdate><title>Reproductive toxicity of lead, cadmium, and phthalate exposure in men</title><author>Pant, Niraj ; Kumar, G ; Upadhyay, A. D ; Patel, D. K ; Gupta, Y. K ; Chaturvedi, P. K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-d5bd59c3f04eec7f7df21d692855b2fab2893351cc5301c36cae3d2db700bb43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Abstinence</topic><topic>Adult</topic><topic>Aquatic Pollution</topic><topic>Atmospheric Protection/Air Quality Control/Air Pollution</topic><topic>Biology</topic><topic>Bis(2-ethylhexyl) phthalate</topic><topic>blood serum</topic><topic>Cadmium</topic><topic>Cadmium - metabolism</topic><topic>Cadmium - toxicity</topic><topic>Deoxyribonucleic acid</topic><topic>dibutyl phthalate</topic><topic>Diethyl phthalate</topic><topic>DNA</topic><topic>DNA Damage</topic><topic>Earth and Environmental Science</topic><topic>Ecotoxicology</topic><topic>Environment</topic><topic>Environmental Chemistry</topic><topic>Environmental Exposure</topic><topic>Environmental Health</topic><topic>Environmental Pollutants - metabolism</topic><topic>Environmental Pollutants - toxicity</topic><topic>Esters</topic><topic>Food contamination & poisoning</topic><topic>Heavy metals</topic><topic>Hormones</topic><topic>Humans</topic><topic>Infertility, Male - chemically induced</topic><topic>Laboratories</topic><topic>Lead</topic><topic>Lead - metabolism</topic><topic>Lead - toxicity</topic><topic>Male</topic><topic>men</topic><topic>Motility</topic><topic>Multiple regression analysis</topic><topic>Occupational exposure</topic><topic>Phthalate esters</topic><topic>Phthalates</topic><topic>Phthalic Acids - metabolism</topic><topic>Phthalic Acids - toxicity</topic><topic>pregnancy</topic><topic>Quality</topic><topic>regression analysis</topic><topic>Reproductive health</topic><topic>reproductive toxicology</topic><topic>Research Article</topic><topic>Semen</topic><topic>Semen - metabolism</topic><topic>Semen Analysis</topic><topic>Sperm</topic><topic>sperm concentration</topic><topic>Sperm Count</topic><topic>sperm motility</topic><topic>Sperm Motility - drug effects</topic><topic>Testosterone</topic><topic>Testosterone - metabolism</topic><topic>toxic substances</topic><topic>Toxicants</topic><topic>Toxicity</topic><topic>Waste Water Technology</topic><topic>Water Management</topic><topic>Water Pollution Control</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pant, Niraj</creatorcontrib><creatorcontrib>Kumar, G</creatorcontrib><creatorcontrib>Upadhyay, A. D</creatorcontrib><creatorcontrib>Patel, D. K</creatorcontrib><creatorcontrib>Gupta, Y. K</creatorcontrib><creatorcontrib>Chaturvedi, P. K</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Ecology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>ABI/INFORM Complete</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Global (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Business Premium Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Business Premium Collection (Alumni)</collection><collection>Health Research Premium Collection</collection><collection>ABI/INFORM Global (Corporate)</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Business Collection (Alumni Edition)</collection><collection>ProQuest Business Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ABI/INFORM Professional Advanced</collection><collection>ABI/INFORM Global</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Science Journals</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>One Business (ProQuest)</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>Environment Abstracts</collection><collection>Environment Abstracts</collection><jtitle>Environmental science and pollution research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pant, Niraj</au><au>Kumar, G</au><au>Upadhyay, A. D</au><au>Patel, D. K</au><au>Gupta, Y. K</au><au>Chaturvedi, P. K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reproductive toxicity of lead, cadmium, and phthalate exposure in men</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><addtitle>Environ Sci Pollut Res Int</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>21</volume><issue>18</issue><spage>11066</spage><epage>11074</epage><pages>11066-11074</pages><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>Environmental toxicants viz lead or cadmium and phthalate esters (di(2-ethylhexyl) phthalate [DEHP], dibutyl phthalate [DBP], and diethyl phthalate [DEP]) widely found in different environmental strata are linked to deteriorating male reproductive health. The objective was to assess the relationships between the seminal lead, cadmium, and phthalate (DEHP, DBP, DEP) concentrations at environmental level and serum hormone levels and semen quality in non-occupationally exposed men and specify the effect of individual and combined exposure of toxicants on semen quality. A study of 60 male partners of couples attending the Andrology Laboratory of the Reproductive Biology Department, All India Institute of Medical Sciences (AIIMS), New Delhi, India for semen analysis to assess their inability to achieve a pregnancy was selected for the study. The results of univariate and stepwise multiple regression analysis in the unadjusted model showed a significant correlation between lead or cadmium and phthalates DEHP/DBP/DEP and sperm motility, sperm concentration, and DNA damage. After adjusting for potential confounders, an association with lead or DEHP was only observed. The present data shows that lead (Pb) or cadmium (Cd) or phthalates might independently contribute to decline in semen quality and induce DNA damage. Phthalates might influence reproductive hormone testosterone. These findings are significant in light of the fact that men are exposed to a volley of chemicals; however, due to the small sample size, our finding needs to be confirmed in a larger population.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>24816463</pmid><doi>10.1007/s11356-014-2986-5</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0944-1344 |
| ispartof | Environmental science and pollution research international, 2014-09, Vol.21 (18), p.11066-11074 |
| issn | 0944-1344 1614-7499 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1566841520 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Abstinence Adult Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Biology Bis(2-ethylhexyl) phthalate blood serum Cadmium Cadmium - metabolism Cadmium - toxicity Deoxyribonucleic acid dibutyl phthalate Diethyl phthalate DNA DNA Damage Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Exposure Environmental Health Environmental Pollutants - metabolism Environmental Pollutants - toxicity Esters Food contamination & poisoning Heavy metals Hormones Humans Infertility, Male - chemically induced Laboratories Lead Lead - metabolism Lead - toxicity Male men Motility Multiple regression analysis Occupational exposure Phthalate esters Phthalates Phthalic Acids - metabolism Phthalic Acids - toxicity pregnancy Quality regression analysis Reproductive health reproductive toxicology Research Article Semen Semen - metabolism Semen Analysis Sperm sperm concentration Sperm Count sperm motility Sperm Motility - drug effects Testosterone Testosterone - metabolism toxic substances Toxicants Toxicity Waste Water Technology Water Management Water Pollution Control Young Adult |
| title | Reproductive toxicity of lead, cadmium, and phthalate exposure in men |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T01%3A01%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Reproductive%20toxicity%20of%20lead,%20cadmium,%20and%20phthalate%20exposure%20in%20men&rft.jtitle=Environmental%20science%20and%20pollution%20research%20international&rft.au=Pant,%20Niraj&rft.date=2014-09-01&rft.volume=21&rft.issue=18&rft.spage=11066&rft.epage=11074&rft.pages=11066-11074&rft.issn=0944-1344&rft.eissn=1614-7499&rft_id=info:doi/10.1007/s11356-014-2986-5&rft_dat=%3Cproquest_cross%3E4054899301%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1788595887&rft_id=info:pmid/24816463&rfr_iscdi=true |