Pendrin and NIS antibodies are absent in healthy individuals and are rare in autoimmune thyroid disease: evidence from a Danish twin study
Objective Antibodies against thyroglobulin, thyroid peroxidase and the TSH receptor are accepted as pathophysiological and diagnostic biomarkers in autoimmune thyroid disease (AITD). In contrast, the prevalence, aetiology and clinical relevance of autoantibodies against the human sodium‐iodine sympo...
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| Veröffentlicht in: | Clinical endocrinology (Oxford) 2014-09, Vol.81 (3), p.440-444 |
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| creator | Brix, Thomas H. Hegedüs, Laszlo Weetman, Anthony P. Kemp, Helen E. |
| description | Objective
Antibodies against thyroglobulin, thyroid peroxidase and the TSH receptor are accepted as pathophysiological and diagnostic biomarkers in autoimmune thyroid disease (AITD). In contrast, the prevalence, aetiology and clinical relevance of autoantibodies against the human sodium‐iodine symporter (NISAb) and pendrin (PenAb) remain unclear. The objectives of the study were to investigate the presence of NISAb and PenAb in Danish twins, with and without AITD, to study whether the published variations in NISAb and PenAb frequencies were related to differences in methodology or study populations, and to evaluate whether the presence of NISAb or PenAb most likely results from genetic or nongenetic factors.
Methods
Sera from 93 patients with AITD and 230 healthy controls were evaluated for NISAb and PenAb using radioligand binding assays (RBA).
Results
Patients with AITD had a higher prevalence than the controls: NISAb: 17% vs 0% (P |
| doi_str_mv | 10.1111/cen.12434 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1566841348</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1549177233</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5244-eb9733fd7fbd54c10983c225a9a060b3ecbba350fc7bb106ebc93d968d18a26e3</originalsourceid><addsrcrecordid>eNqN0ctu1DAUBuAIgehQWPACyBJCgkVa35N0h4ZSisqAVKBLy5cTjUviFDuhzCvw1DidaZGQkPDC9uL7z5F9iuIpwQckr0ML4YBQzvi9YkGYFCWlUtwvFphhXGIp-V7xKKVLjLGocfWw2KNcEopruSh-fYLgog9IB4dWp-f5HL0ZnIeEdASkTYIwogzWoLtxvclX5394N-ku3YRmFedtLjKNg-_7KQDKNA7eIecT6ARHCHIIggXUxqFHGr3Rwac1Gq9zLo2T2zwuHrS5KDzZnfvFl7fHn5fvyrOPJ6fL12elFZTzEkxTMda6qjVOcEtwUzNLqdCNxhIbBtYYzQRubWUMwRKMbZhrZO1IrakEtl-83Na9isP3CdKoep8sdJ0OMExJESFlzQnj9X9Q3pCqooxl-vwvejlMMeSHzKqmtOaCZvVqq2wcUorQqqvoex03imA1z1LlWaqbWWb7bFdxMj24O3k7vAxe7IBOVndt1MH69MfVsso_JbI73Lpr38Hm3x3V8nh127rcJnwa4eddQsdvSlasEupidaL4e3pBvpIP6pz9BiGwxG4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1548228452</pqid></control><display><type>article</type><title>Pendrin and NIS antibodies are absent in healthy individuals and are rare in autoimmune thyroid disease: evidence from a Danish twin study</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Brix, Thomas H. ; Hegedüs, Laszlo ; Weetman, Anthony P. ; Kemp, Helen E.</creator><creatorcontrib>Brix, Thomas H. ; Hegedüs, Laszlo ; Weetman, Anthony P. ; Kemp, Helen E.</creatorcontrib><description>Objective
Antibodies against thyroglobulin, thyroid peroxidase and the TSH receptor are accepted as pathophysiological and diagnostic biomarkers in autoimmune thyroid disease (AITD). In contrast, the prevalence, aetiology and clinical relevance of autoantibodies against the human sodium‐iodine symporter (NISAb) and pendrin (PenAb) remain unclear. The objectives of the study were to investigate the presence of NISAb and PenAb in Danish twins, with and without AITD, to study whether the published variations in NISAb and PenAb frequencies were related to differences in methodology or study populations, and to evaluate whether the presence of NISAb or PenAb most likely results from genetic or nongenetic factors.
Methods
Sera from 93 patients with AITD and 230 healthy controls were evaluated for NISAb and PenAb using radioligand binding assays (RBA).
Results
Patients with AITD had a higher prevalence than the controls: NISAb: 17% vs 0% (P < 0·001) and PenAb: 11% vs 0% (P < 0·001). Subdividing according to cause of AITD yielded similar results: 20% (11/56) of patients with Graves' disease (GD) and 14% (5/37) of patients with Hashimoto's thyroiditis (HT) had NISAb, (P < 0·05, vs control population). Seven of 56 (13%) patients with GD and three of 37 (8%) patients with HT had PenAb (P < 0·05 vs control population). No twin pairs were concordant for NISAb or PenAb, not even among twin pairs concordant for AITD.
Conclusions
In accord with studies using the same RBAs, the frequency of NISAb and PenAb was low in Danish patients with AITD and absent in healthy individuals, suggesting that differences between studies rely on assay differences. The skewed distribution of NISAb and PenAb within AITD concordant twin pairs suggests that NISAb and PenAb are likely attributable to the effects of environmental factors acting in genetic susceptible individuals.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/cen.12434</identifier><identifier>PMID: 24612086</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Antibodies - blood ; Antibodies - immunology ; Antiporters - immunology ; Biological and medical sciences ; Endocrinopathies ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Male ; Medical sciences ; Membrane Transport Proteins - immunology ; Middle Aged ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Thyroglobulin - immunology ; Thyroid. Thyroid axis (diseases) ; Thyroiditis, Autoimmune - blood ; Thyroiditis, Autoimmune - immunology ; Vertebrates: endocrinology</subject><ispartof>Clinical endocrinology (Oxford), 2014-09, Vol.81 (3), p.440-444</ispartof><rights>2014 John Wiley & Sons Ltd</rights><rights>2015 INIST-CNRS</rights><rights>2014 John Wiley & Sons Ltd.</rights><rights>Copyright © 2014 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5244-eb9733fd7fbd54c10983c225a9a060b3ecbba350fc7bb106ebc93d968d18a26e3</citedby><cites>FETCH-LOGICAL-c5244-eb9733fd7fbd54c10983c225a9a060b3ecbba350fc7bb106ebc93d968d18a26e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcen.12434$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcen.12434$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28677335$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24612086$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brix, Thomas H.</creatorcontrib><creatorcontrib>Hegedüs, Laszlo</creatorcontrib><creatorcontrib>Weetman, Anthony P.</creatorcontrib><creatorcontrib>Kemp, Helen E.</creatorcontrib><title>Pendrin and NIS antibodies are absent in healthy individuals and are rare in autoimmune thyroid disease: evidence from a Danish twin study</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol</addtitle><description>Objective
Antibodies against thyroglobulin, thyroid peroxidase and the TSH receptor are accepted as pathophysiological and diagnostic biomarkers in autoimmune thyroid disease (AITD). In contrast, the prevalence, aetiology and clinical relevance of autoantibodies against the human sodium‐iodine symporter (NISAb) and pendrin (PenAb) remain unclear. The objectives of the study were to investigate the presence of NISAb and PenAb in Danish twins, with and without AITD, to study whether the published variations in NISAb and PenAb frequencies were related to differences in methodology or study populations, and to evaluate whether the presence of NISAb or PenAb most likely results from genetic or nongenetic factors.
Methods
Sera from 93 patients with AITD and 230 healthy controls were evaluated for NISAb and PenAb using radioligand binding assays (RBA).
Results
Patients with AITD had a higher prevalence than the controls: NISAb: 17% vs 0% (P < 0·001) and PenAb: 11% vs 0% (P < 0·001). Subdividing according to cause of AITD yielded similar results: 20% (11/56) of patients with Graves' disease (GD) and 14% (5/37) of patients with Hashimoto's thyroiditis (HT) had NISAb, (P < 0·05, vs control population). Seven of 56 (13%) patients with GD and three of 37 (8%) patients with HT had PenAb (P < 0·05 vs control population). No twin pairs were concordant for NISAb or PenAb, not even among twin pairs concordant for AITD.
Conclusions
In accord with studies using the same RBAs, the frequency of NISAb and PenAb was low in Danish patients with AITD and absent in healthy individuals, suggesting that differences between studies rely on assay differences. The skewed distribution of NISAb and PenAb within AITD concordant twin pairs suggests that NISAb and PenAb are likely attributable to the effects of environmental factors acting in genetic susceptible individuals.</description><subject>Adult</subject><subject>Aged</subject><subject>Antibodies - blood</subject><subject>Antibodies - immunology</subject><subject>Antiporters - immunology</subject><subject>Biological and medical sciences</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Membrane Transport Proteins - immunology</subject><subject>Middle Aged</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Thyroglobulin - immunology</subject><subject>Thyroid. Thyroid axis (diseases)</subject><subject>Thyroiditis, Autoimmune - blood</subject><subject>Thyroiditis, Autoimmune - immunology</subject><subject>Vertebrates: endocrinology</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0ctu1DAUBuAIgehQWPACyBJCgkVa35N0h4ZSisqAVKBLy5cTjUviFDuhzCvw1DidaZGQkPDC9uL7z5F9iuIpwQckr0ML4YBQzvi9YkGYFCWlUtwvFphhXGIp-V7xKKVLjLGocfWw2KNcEopruSh-fYLgog9IB4dWp-f5HL0ZnIeEdASkTYIwogzWoLtxvclX5394N-ku3YRmFedtLjKNg-_7KQDKNA7eIecT6ARHCHIIggXUxqFHGr3Rwac1Gq9zLo2T2zwuHrS5KDzZnfvFl7fHn5fvyrOPJ6fL12elFZTzEkxTMda6qjVOcEtwUzNLqdCNxhIbBtYYzQRubWUMwRKMbZhrZO1IrakEtl-83Na9isP3CdKoep8sdJ0OMExJESFlzQnj9X9Q3pCqooxl-vwvejlMMeSHzKqmtOaCZvVqq2wcUorQqqvoex03imA1z1LlWaqbWWb7bFdxMj24O3k7vAxe7IBOVndt1MH69MfVsso_JbI73Lpr38Hm3x3V8nh127rcJnwa4eddQsdvSlasEupidaL4e3pBvpIP6pz9BiGwxG4</recordid><startdate>201409</startdate><enddate>201409</enddate><creator>Brix, Thomas H.</creator><creator>Hegedüs, Laszlo</creator><creator>Weetman, Anthony P.</creator><creator>Kemp, Helen E.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>201409</creationdate><title>Pendrin and NIS antibodies are absent in healthy individuals and are rare in autoimmune thyroid disease: evidence from a Danish twin study</title><author>Brix, Thomas H. ; Hegedüs, Laszlo ; Weetman, Anthony P. ; Kemp, Helen E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5244-eb9733fd7fbd54c10983c225a9a060b3ecbba350fc7bb106ebc93d968d18a26e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antibodies - blood</topic><topic>Antibodies - immunology</topic><topic>Antiporters - immunology</topic><topic>Biological and medical sciences</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Membrane Transport Proteins - immunology</topic><topic>Middle Aged</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Thyroglobulin - immunology</topic><topic>Thyroid. Thyroid axis (diseases)</topic><topic>Thyroiditis, Autoimmune - blood</topic><topic>Thyroiditis, Autoimmune - immunology</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brix, Thomas H.</creatorcontrib><creatorcontrib>Hegedüs, Laszlo</creatorcontrib><creatorcontrib>Weetman, Anthony P.</creatorcontrib><creatorcontrib>Kemp, Helen E.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brix, Thomas H.</au><au>Hegedüs, Laszlo</au><au>Weetman, Anthony P.</au><au>Kemp, Helen E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pendrin and NIS antibodies are absent in healthy individuals and are rare in autoimmune thyroid disease: evidence from a Danish twin study</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol</addtitle><date>2014-09</date><risdate>2014</risdate><volume>81</volume><issue>3</issue><spage>440</spage><epage>444</epage><pages>440-444</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract>Objective
Antibodies against thyroglobulin, thyroid peroxidase and the TSH receptor are accepted as pathophysiological and diagnostic biomarkers in autoimmune thyroid disease (AITD). In contrast, the prevalence, aetiology and clinical relevance of autoantibodies against the human sodium‐iodine symporter (NISAb) and pendrin (PenAb) remain unclear. The objectives of the study were to investigate the presence of NISAb and PenAb in Danish twins, with and without AITD, to study whether the published variations in NISAb and PenAb frequencies were related to differences in methodology or study populations, and to evaluate whether the presence of NISAb or PenAb most likely results from genetic or nongenetic factors.
Methods
Sera from 93 patients with AITD and 230 healthy controls were evaluated for NISAb and PenAb using radioligand binding assays (RBA).
Results
Patients with AITD had a higher prevalence than the controls: NISAb: 17% vs 0% (P < 0·001) and PenAb: 11% vs 0% (P < 0·001). Subdividing according to cause of AITD yielded similar results: 20% (11/56) of patients with Graves' disease (GD) and 14% (5/37) of patients with Hashimoto's thyroiditis (HT) had NISAb, (P < 0·05, vs control population). Seven of 56 (13%) patients with GD and three of 37 (8%) patients with HT had PenAb (P < 0·05 vs control population). No twin pairs were concordant for NISAb or PenAb, not even among twin pairs concordant for AITD.
Conclusions
In accord with studies using the same RBAs, the frequency of NISAb and PenAb was low in Danish patients with AITD and absent in healthy individuals, suggesting that differences between studies rely on assay differences. The skewed distribution of NISAb and PenAb within AITD concordant twin pairs suggests that NISAb and PenAb are likely attributable to the effects of environmental factors acting in genetic susceptible individuals.</abstract><cop>Oxford</cop><pub>Blackwell Publishing Ltd</pub><pmid>24612086</pmid><doi>10.1111/cen.12434</doi><tpages>5</tpages></addata></record> |
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| ispartof | Clinical endocrinology (Oxford), 2014-09, Vol.81 (3), p.440-444 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Aged Antibodies - blood Antibodies - immunology Antiporters - immunology Biological and medical sciences Endocrinopathies Female Fundamental and applied biological sciences. Psychology Humans Male Medical sciences Membrane Transport Proteins - immunology Middle Aged Non tumoral diseases. Target tissue resistance. Benign neoplasms Thyroglobulin - immunology Thyroid. Thyroid axis (diseases) Thyroiditis, Autoimmune - blood Thyroiditis, Autoimmune - immunology Vertebrates: endocrinology |
| title | Pendrin and NIS antibodies are absent in healthy individuals and are rare in autoimmune thyroid disease: evidence from a Danish twin study |
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