Safety and activity of ibrutinib plus rituximab for patients with high-risk chronic lymphocytic leukaemia: a single-arm, phase 2 study

Summary Background Ibrutinib, an orally administered covalent inhibitor of Bruton's tyrosine kinase (BTK), is an effective treatment for relapsed chronic lymphocytic leukaemia (CLL). We investigated the activity and safety of the combination of ibrutinib with the monoclonal antibody rituximab i...

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Veröffentlicht in:	The lancet oncology 2014-09, Vol.15 (10), p.1090-1099
Hauptverfasser:	Burger, Jan A, Dr, Keating, Michael J, Prof, Wierda, William G, Prof, Hartmann, Elena, MD, Hoellenriegel, Julia, MS, Rosin, Nathalie Y, PhD, de Weerdt, Iris, MD, Jeyakumar, Ghayathri, MD, Ferrajoli, Alessandra, MD, Cardenas-Turanzas, Marylou, PhD, Lerner, Susan, MS, Jorgensen, Jeffrey L, MD, Nogueras-González, Graciela M, MS, Zacharian, Gracy, MS, Huang, Xuelin, PhD, Kantarjian, Hagop, Prof, Garg, Naveen, MD, Rosenwald, Andreas, Prof, O'Brien, Susan, Prof
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Aged Aged, 80 and over Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Murine-Derived - adverse effects Antibodies, Monoclonal, Murine-Derived - therapeutic use Antineoplastic Combined Chemotherapy Protocols - therapeutic use Cell adhesion & migration Constipation Disease-Free Survival Dose-Response Relationship, Drug Drug Administration Schedule Drug therapy Female Hematology, Oncology and Palliative Medicine Humans Infections Insomnia Kaplan-Meier Estimate Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Leukemia, Lymphocytic, Chronic, B-Cell - mortality Male Maximum Tolerated Dose Medical prognosis Middle Aged Mutation Neoplasm Recurrence, Local - diagnosis Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - mortality Patient Selection Prognosis Pyrazoles - administration & dosage Pyrazoles - adverse effects Pyrimidines - administration & dosage Pyrimidines - adverse effects Quality of life Rituximab Survival Rate Treatment Outcome
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