Guselkumab (an IL-23–specific mAb) demonstrates clinical and molecular response in patients with moderate-to-severe psoriasis

Background IL-23 expression is increased in psoriatic lesions and might regulate TH 17 T-cell counts in patients with psoriasis. Objectives We sought to test a novel IL-23–specific therapeutic agent for the treatment of psoriasis. Methods In this randomized, double-blind, placebo-controlled study th...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2014-04, Vol.133 (4), p.1032-1040
Hauptverfasser:	Sofen, Howard, MD, Smith, Stacy, MD, Matheson, Robert T., MD, Leonardi, Craig L., MD, Calderon, Cesar, PhD, Brodmerkel, Carrie, PhD, Li, Katherine, MS, Campbell, Kim, PhD, Marciniak, Stanley J., MBA, Wasfi, Yasmine, MD, PhD, Wang, Yuhua, PhD, Szapary, Philippe, MD, Krueger, James G., MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal - therapeutic use Antibodies, Neutralizing - administration & dosage Antibodies, Neutralizing - adverse effects Antibodies, Neutralizing - therapeutic use Biological and medical sciences Biomarkers Biopsy Cluster Analysis Cytokines Cytokines - blood Cytokines - metabolism Dermatology Disease Drug therapy Fundamental and applied biological sciences. Psychology Fundamental immunology Gene expression Gene Expression Profiling guselkumab Histology Humans Hypothesis testing IL-23 Immunopathology Inflammation Mediators - blood Inflammation Mediators - metabolism Interleukin-17 - blood Interleukin-23 - antagonists & inhibitors Lymphocytes Medical sciences Patients Proteins Psoriasis Psoriasis - drug therapy Psoriasis - genetics Psoriasis - immunology Psoriasis - metabolism Psoriasis - pathology Psoriasis Area and Severity Index Psoriasis. Parapsoriasis. Lichen Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis serum skin Skin - immunology Skin - pathology Statistical methods Studies T cell TH17 Th17 Cells - immunology Th17 Cells - metabolism Treatment Outcome
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