Low vitamin D levels are associated with atopic dermatitis, but not allergic rhinitis, asthma, or IgE sensitization, in the adult Korean population
Background The effect of vitamin D on allergic conditions is unclear. In particular, large-scale, population-based studies examining this relationship in adult Asian populations are lacking. Objective To evaluate the association between serum vitamin D levels and allergic conditions in the general a...
Gespeichert in:
| Veröffentlicht in: | Journal of allergy and clinical immunology 2014-04, Vol.133 (4), p.1048-1055 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1055 |
|---|---|
| container_issue | 4 |
| container_start_page | 1048 |
| container_title | Journal of allergy and clinical immunology |
| container_volume | 133 |
| creator | Cheng, Hui Mei, MD Kim, Sunmi, MD Park, Gyeong-Hun, MD, PhD Chang, Sung Eun, MD, PhD Bang, Seunghyun, PhD Won, Chong Hyun, MD, PhD Lee, Mi Woo, MD, PhD Choi, Jee Ho, MD, PhD Moon, Kee Chan, MD, PhD |
| description | Background The effect of vitamin D on allergic conditions is unclear. In particular, large-scale, population-based studies examining this relationship in adult Asian populations are lacking. Objective To evaluate the association between serum vitamin D levels and allergic conditions in the general adult Korean population. Methods A cross-sectional study was performed by using data collected from 15,212 individuals 19 years or older who participated in the Korean National Health and Nutrition Examination Survey from 2008 to 2010. The confounder-adjusted mean serum 25-hydroxyvitamin D (25[OH]D) levels of participants with and without allergic conditions (including atopic dermatitis, asthma, allergic rhinitis, and increased total and allergen-specific serum IgE) were compared by using multiple linear regression analyses. Multiple logistic regression analyses with confounder adjustment estimated the odds ratios (ORs) for developing each condition according to adequate, inadequate, or deficient serum 25(OH)D levels. Results After adjusting for potential confounders, mean serum 25(OH)D levels were significantly lower in participants diagnosed with atopic dermatitis than in those without this diagnosis (mean ± SE, 18.58 ± 0.29 ng/mL vs 19.20 ± 0.15 ng/mL; P = .02). Compared with participants with adequate vitamin D levels (≥20 ng/mL), confounder-adjusted ORs of atopic dermatitis were significantly higher in those with inadequate (12-19.99 ng/mL) or deficient ( |
| doi_str_mv | 10.1016/j.jaci.2013.10.055 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1566838791</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0091674913017685</els_id><sourcerecordid>1516744814</sourcerecordid><originalsourceid>FETCH-LOGICAL-c535t-a893facd9e6658bd7d924a6f4260c2b0b44a684c9048dda6b1c8743d9a71a35b3</originalsourceid><addsrcrecordid>eNqNksGKFDEQhhtR3HH1BTxIQAQPM2PSSafTIIKsqy4OeFDPoTqp2cnY3RmT9Czra_jCpp3RhT3InkJVfZU_VfmL4imjS0aZfLVdbsG4ZUkZz4klrap7xYzRpl5IVVb3ixmlDVvIWjQnxaMYtzTHXDUPi5NScKVyNCt-rfwV2bsEvRvIO9LhHrtIICCBGL1xkNCSK5c2BJLfOUMshh6SSy7OSTsmMvhEoOswXOZi2LjhUIKYNj3MiQ_k4vKcRBxiLvzMnX6Yk6yVNlnCjl0in3xAGMjO78buT_1x8WANXcQnx_O0-Pb-_OvZx8Xq84eLs7erhal4lRagGr4GYxuUslKtrW1TCpBrUUpqypa2IkdKmIYKZS3IlhlVC24bqBnwquWnxcvDvbvgf4wYk-5dNNh1MKAfo2aVlIqrumF3QFnes1BM3AVlqmR5_Rl9fgvd-jEMeWbNpBB1XSuqMlUeKBN8jAHXehdcD-FaM6onI-itnoygJyNMuWyE3PTsePXY9mj_tfz9-Qy8OAIQDXTrAINx8YZTWZ-KMnOvD1z2Be4dBh2Nw8GgdQFN0ta7_7_jza1202WPZMXveI3xZl4dS031l8myk2MZp6yWquK_AXvJ5b4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1644777808</pqid></control><display><type>article</type><title>Low vitamin D levels are associated with atopic dermatitis, but not allergic rhinitis, asthma, or IgE sensitization, in the adult Korean population</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Cheng, Hui Mei, MD ; Kim, Sunmi, MD ; Park, Gyeong-Hun, MD, PhD ; Chang, Sung Eun, MD, PhD ; Bang, Seunghyun, PhD ; Won, Chong Hyun, MD, PhD ; Lee, Mi Woo, MD, PhD ; Choi, Jee Ho, MD, PhD ; Moon, Kee Chan, MD, PhD</creator><creatorcontrib>Cheng, Hui Mei, MD ; Kim, Sunmi, MD ; Park, Gyeong-Hun, MD, PhD ; Chang, Sung Eun, MD, PhD ; Bang, Seunghyun, PhD ; Won, Chong Hyun, MD, PhD ; Lee, Mi Woo, MD, PhD ; Choi, Jee Ho, MD, PhD ; Moon, Kee Chan, MD, PhD</creatorcontrib><description>Background The effect of vitamin D on allergic conditions is unclear. In particular, large-scale, population-based studies examining this relationship in adult Asian populations are lacking. Objective To evaluate the association between serum vitamin D levels and allergic conditions in the general adult Korean population. Methods A cross-sectional study was performed by using data collected from 15,212 individuals 19 years or older who participated in the Korean National Health and Nutrition Examination Survey from 2008 to 2010. The confounder-adjusted mean serum 25-hydroxyvitamin D (25[OH]D) levels of participants with and without allergic conditions (including atopic dermatitis, asthma, allergic rhinitis, and increased total and allergen-specific serum IgE) were compared by using multiple linear regression analyses. Multiple logistic regression analyses with confounder adjustment estimated the odds ratios (ORs) for developing each condition according to adequate, inadequate, or deficient serum 25(OH)D levels. Results After adjusting for potential confounders, mean serum 25(OH)D levels were significantly lower in participants diagnosed with atopic dermatitis than in those without this diagnosis (mean ± SE, 18.58 ± 0.29 ng/mL vs 19.20 ± 0.15 ng/mL; P = .02). Compared with participants with adequate vitamin D levels (≥20 ng/mL), confounder-adjusted ORs of atopic dermatitis were significantly higher in those with inadequate (12-19.99 ng/mL) or deficient (<12 ng/mL) levels (OR [95% CI], 1.50 [1.10-2.06] and 1.48 [1.04-2.12], respectively; P = .02). This relationship was not observed in participants with the other allergic conditions. Conclusion Vitamin D–insufficient adult individuals within the general Korean population have an increased likelihood of atopic dermatitis, but not asthma, allergic rhinitis, or IgE sensitization.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/j.jaci.2013.10.055</identifier><identifier>PMID: 24388009</identifier><identifier>CODEN: JACIBY</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Allergic diseases ; allergic rhinitis ; allergy ; Allergy and Immunology ; Asian ; Asian Continental Ancestry Group ; Asthma ; Asthma - blood ; Asthma - epidemiology ; Asthma - immunology ; atopic dermatitis ; Biological and medical sciences ; Dermatitis, Atopic - blood ; Dermatitis, Atopic - epidemiology ; Dermatitis, Atopic - immunology ; Disease control ; Family income ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Households ; Humans ; IgE ; Immunoglobulin E - immunology ; Immunopathology ; KNHANES ; Korean ; Male ; Medical sciences ; Middle Aged ; Non tumoral diseases ; Nutrition Surveys ; Otorhinolaryngology. Stomatology ; Population ; Republic of Korea - epidemiology ; Rhinitis, Allergic ; Rhinitis, Allergic, Perennial - blood ; Rhinitis, Allergic, Perennial - epidemiology ; Rhinitis, Allergic, Perennial - immunology ; Risk Factors ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Skin allergic diseases. Stinging insect allergies ; Studies ; Tuberculosis ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Young Adult</subject><ispartof>Journal of allergy and clinical immunology, 2014-04, Vol.133 (4), p.1048-1055</ispartof><rights>American Academy of Allergy, Asthma & Immunology</rights><rights>2013 American Academy of Allergy, Asthma & Immunology</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2013 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Apr 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c535t-a893facd9e6658bd7d924a6f4260c2b0b44a684c9048dda6b1c8743d9a71a35b3</citedby><cites>FETCH-LOGICAL-c535t-a893facd9e6658bd7d924a6f4260c2b0b44a684c9048dda6b1c8743d9a71a35b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jaci.2013.10.055$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28447042$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24388009$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheng, Hui Mei, MD</creatorcontrib><creatorcontrib>Kim, Sunmi, MD</creatorcontrib><creatorcontrib>Park, Gyeong-Hun, MD, PhD</creatorcontrib><creatorcontrib>Chang, Sung Eun, MD, PhD</creatorcontrib><creatorcontrib>Bang, Seunghyun, PhD</creatorcontrib><creatorcontrib>Won, Chong Hyun, MD, PhD</creatorcontrib><creatorcontrib>Lee, Mi Woo, MD, PhD</creatorcontrib><creatorcontrib>Choi, Jee Ho, MD, PhD</creatorcontrib><creatorcontrib>Moon, Kee Chan, MD, PhD</creatorcontrib><title>Low vitamin D levels are associated with atopic dermatitis, but not allergic rhinitis, asthma, or IgE sensitization, in the adult Korean population</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>Background The effect of vitamin D on allergic conditions is unclear. In particular, large-scale, population-based studies examining this relationship in adult Asian populations are lacking. Objective To evaluate the association between serum vitamin D levels and allergic conditions in the general adult Korean population. Methods A cross-sectional study was performed by using data collected from 15,212 individuals 19 years or older who participated in the Korean National Health and Nutrition Examination Survey from 2008 to 2010. The confounder-adjusted mean serum 25-hydroxyvitamin D (25[OH]D) levels of participants with and without allergic conditions (including atopic dermatitis, asthma, allergic rhinitis, and increased total and allergen-specific serum IgE) were compared by using multiple linear regression analyses. Multiple logistic regression analyses with confounder adjustment estimated the odds ratios (ORs) for developing each condition according to adequate, inadequate, or deficient serum 25(OH)D levels. Results After adjusting for potential confounders, mean serum 25(OH)D levels were significantly lower in participants diagnosed with atopic dermatitis than in those without this diagnosis (mean ± SE, 18.58 ± 0.29 ng/mL vs 19.20 ± 0.15 ng/mL; P = .02). Compared with participants with adequate vitamin D levels (≥20 ng/mL), confounder-adjusted ORs of atopic dermatitis were significantly higher in those with inadequate (12-19.99 ng/mL) or deficient (<12 ng/mL) levels (OR [95% CI], 1.50 [1.10-2.06] and 1.48 [1.04-2.12], respectively; P = .02). This relationship was not observed in participants with the other allergic conditions. Conclusion Vitamin D–insufficient adult individuals within the general Korean population have an increased likelihood of atopic dermatitis, but not asthma, allergic rhinitis, or IgE sensitization.</description><subject>Adult</subject><subject>Allergic diseases</subject><subject>allergic rhinitis</subject><subject>allergy</subject><subject>Allergy and Immunology</subject><subject>Asian</subject><subject>Asian Continental Ancestry Group</subject><subject>Asthma</subject><subject>Asthma - blood</subject><subject>Asthma - epidemiology</subject><subject>Asthma - immunology</subject><subject>atopic dermatitis</subject><subject>Biological and medical sciences</subject><subject>Dermatitis, Atopic - blood</subject><subject>Dermatitis, Atopic - epidemiology</subject><subject>Dermatitis, Atopic - immunology</subject><subject>Disease control</subject><subject>Family income</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Households</subject><subject>Humans</subject><subject>IgE</subject><subject>Immunoglobulin E - immunology</subject><subject>Immunopathology</subject><subject>KNHANES</subject><subject>Korean</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Non tumoral diseases</subject><subject>Nutrition Surveys</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Population</subject><subject>Republic of Korea - epidemiology</subject><subject>Rhinitis, Allergic</subject><subject>Rhinitis, Allergic, Perennial - blood</subject><subject>Rhinitis, Allergic, Perennial - epidemiology</subject><subject>Rhinitis, Allergic, Perennial - immunology</subject><subject>Risk Factors</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Skin allergic diseases. Stinging insect allergies</subject><subject>Studies</subject><subject>Tuberculosis</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><subject>Vitamin D</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>Young Adult</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNksGKFDEQhhtR3HH1BTxIQAQPM2PSSafTIIKsqy4OeFDPoTqp2cnY3RmT9Czra_jCpp3RhT3InkJVfZU_VfmL4imjS0aZfLVdbsG4ZUkZz4klrap7xYzRpl5IVVb3ixmlDVvIWjQnxaMYtzTHXDUPi5NScKVyNCt-rfwV2bsEvRvIO9LhHrtIICCBGL1xkNCSK5c2BJLfOUMshh6SSy7OSTsmMvhEoOswXOZi2LjhUIKYNj3MiQ_k4vKcRBxiLvzMnX6Yk6yVNlnCjl0in3xAGMjO78buT_1x8WANXcQnx_O0-Pb-_OvZx8Xq84eLs7erhal4lRagGr4GYxuUslKtrW1TCpBrUUpqypa2IkdKmIYKZS3IlhlVC24bqBnwquWnxcvDvbvgf4wYk-5dNNh1MKAfo2aVlIqrumF3QFnes1BM3AVlqmR5_Rl9fgvd-jEMeWbNpBB1XSuqMlUeKBN8jAHXehdcD-FaM6onI-itnoygJyNMuWyE3PTsePXY9mj_tfz9-Qy8OAIQDXTrAINx8YZTWZ-KMnOvD1z2Be4dBh2Nw8GgdQFN0ta7_7_jza1202WPZMXveI3xZl4dS031l8myk2MZp6yWquK_AXvJ5b4</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Cheng, Hui Mei, MD</creator><creator>Kim, Sunmi, MD</creator><creator>Park, Gyeong-Hun, MD, PhD</creator><creator>Chang, Sung Eun, MD, PhD</creator><creator>Bang, Seunghyun, PhD</creator><creator>Won, Chong Hyun, MD, PhD</creator><creator>Lee, Mi Woo, MD, PhD</creator><creator>Choi, Jee Ho, MD, PhD</creator><creator>Moon, Kee Chan, MD, PhD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20140401</creationdate><title>Low vitamin D levels are associated with atopic dermatitis, but not allergic rhinitis, asthma, or IgE sensitization, in the adult Korean population</title><author>Cheng, Hui Mei, MD ; Kim, Sunmi, MD ; Park, Gyeong-Hun, MD, PhD ; Chang, Sung Eun, MD, PhD ; Bang, Seunghyun, PhD ; Won, Chong Hyun, MD, PhD ; Lee, Mi Woo, MD, PhD ; Choi, Jee Ho, MD, PhD ; Moon, Kee Chan, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c535t-a893facd9e6658bd7d924a6f4260c2b0b44a684c9048dda6b1c8743d9a71a35b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Allergic diseases</topic><topic>allergic rhinitis</topic><topic>allergy</topic><topic>Allergy and Immunology</topic><topic>Asian</topic><topic>Asian Continental Ancestry Group</topic><topic>Asthma</topic><topic>Asthma - blood</topic><topic>Asthma - epidemiology</topic><topic>Asthma - immunology</topic><topic>atopic dermatitis</topic><topic>Biological and medical sciences</topic><topic>Dermatitis, Atopic - blood</topic><topic>Dermatitis, Atopic - epidemiology</topic><topic>Dermatitis, Atopic - immunology</topic><topic>Disease control</topic><topic>Family income</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Households</topic><topic>Humans</topic><topic>IgE</topic><topic>Immunoglobulin E - immunology</topic><topic>Immunopathology</topic><topic>KNHANES</topic><topic>Korean</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Non tumoral diseases</topic><topic>Nutrition Surveys</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Population</topic><topic>Republic of Korea - epidemiology</topic><topic>Rhinitis, Allergic</topic><topic>Rhinitis, Allergic, Perennial - blood</topic><topic>Rhinitis, Allergic, Perennial - epidemiology</topic><topic>Rhinitis, Allergic, Perennial - immunology</topic><topic>Risk Factors</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Skin allergic diseases. Stinging insect allergies</topic><topic>Studies</topic><topic>Tuberculosis</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><topic>Vitamin D</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Hui Mei, MD</creatorcontrib><creatorcontrib>Kim, Sunmi, MD</creatorcontrib><creatorcontrib>Park, Gyeong-Hun, MD, PhD</creatorcontrib><creatorcontrib>Chang, Sung Eun, MD, PhD</creatorcontrib><creatorcontrib>Bang, Seunghyun, PhD</creatorcontrib><creatorcontrib>Won, Chong Hyun, MD, PhD</creatorcontrib><creatorcontrib>Lee, Mi Woo, MD, PhD</creatorcontrib><creatorcontrib>Choi, Jee Ho, MD, PhD</creatorcontrib><creatorcontrib>Moon, Kee Chan, MD, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Hui Mei, MD</au><au>Kim, Sunmi, MD</au><au>Park, Gyeong-Hun, MD, PhD</au><au>Chang, Sung Eun, MD, PhD</au><au>Bang, Seunghyun, PhD</au><au>Won, Chong Hyun, MD, PhD</au><au>Lee, Mi Woo, MD, PhD</au><au>Choi, Jee Ho, MD, PhD</au><au>Moon, Kee Chan, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low vitamin D levels are associated with atopic dermatitis, but not allergic rhinitis, asthma, or IgE sensitization, in the adult Korean population</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>133</volume><issue>4</issue><spage>1048</spage><epage>1055</epage><pages>1048-1055</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>Background The effect of vitamin D on allergic conditions is unclear. In particular, large-scale, population-based studies examining this relationship in adult Asian populations are lacking. Objective To evaluate the association between serum vitamin D levels and allergic conditions in the general adult Korean population. Methods A cross-sectional study was performed by using data collected from 15,212 individuals 19 years or older who participated in the Korean National Health and Nutrition Examination Survey from 2008 to 2010. The confounder-adjusted mean serum 25-hydroxyvitamin D (25[OH]D) levels of participants with and without allergic conditions (including atopic dermatitis, asthma, allergic rhinitis, and increased total and allergen-specific serum IgE) were compared by using multiple linear regression analyses. Multiple logistic regression analyses with confounder adjustment estimated the odds ratios (ORs) for developing each condition according to adequate, inadequate, or deficient serum 25(OH)D levels. Results After adjusting for potential confounders, mean serum 25(OH)D levels were significantly lower in participants diagnosed with atopic dermatitis than in those without this diagnosis (mean ± SE, 18.58 ± 0.29 ng/mL vs 19.20 ± 0.15 ng/mL; P = .02). Compared with participants with adequate vitamin D levels (≥20 ng/mL), confounder-adjusted ORs of atopic dermatitis were significantly higher in those with inadequate (12-19.99 ng/mL) or deficient (<12 ng/mL) levels (OR [95% CI], 1.50 [1.10-2.06] and 1.48 [1.04-2.12], respectively; P = .02). This relationship was not observed in participants with the other allergic conditions. Conclusion Vitamin D–insufficient adult individuals within the general Korean population have an increased likelihood of atopic dermatitis, but not asthma, allergic rhinitis, or IgE sensitization.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>24388009</pmid><doi>10.1016/j.jaci.2013.10.055</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-6749 |
| ispartof | Journal of allergy and clinical immunology, 2014-04, Vol.133 (4), p.1048-1055 |
| issn | 0091-6749 1097-6825 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1566838791 |
| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Allergic diseases allergic rhinitis allergy Allergy and Immunology Asian Asian Continental Ancestry Group Asthma Asthma - blood Asthma - epidemiology Asthma - immunology atopic dermatitis Biological and medical sciences Dermatitis, Atopic - blood Dermatitis, Atopic - epidemiology Dermatitis, Atopic - immunology Disease control Family income Female Fundamental and applied biological sciences. Psychology Fundamental immunology Households Humans IgE Immunoglobulin E - immunology Immunopathology KNHANES Korean Male Medical sciences Middle Aged Non tumoral diseases Nutrition Surveys Otorhinolaryngology. Stomatology Population Republic of Korea - epidemiology Rhinitis, Allergic Rhinitis, Allergic, Perennial - blood Rhinitis, Allergic, Perennial - epidemiology Rhinitis, Allergic, Perennial - immunology Risk Factors Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Skin allergic diseases. Stinging insect allergies Studies Tuberculosis Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Young Adult |
| title | Low vitamin D levels are associated with atopic dermatitis, but not allergic rhinitis, asthma, or IgE sensitization, in the adult Korean population |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T12%3A16%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Low%20vitamin%20D%20levels%20are%20associated%20with%20atopic%20dermatitis,%20but%20not%20allergic%20rhinitis,%20asthma,%20or%20IgE%20sensitization,%20in%20the%20adult%20Korean%20population&rft.jtitle=Journal%20of%20allergy%20and%20clinical%20immunology&rft.au=Cheng,%20Hui%20Mei,%20MD&rft.date=2014-04-01&rft.volume=133&rft.issue=4&rft.spage=1048&rft.epage=1055&rft.pages=1048-1055&rft.issn=0091-6749&rft.eissn=1097-6825&rft.coden=JACIBY&rft_id=info:doi/10.1016/j.jaci.2013.10.055&rft_dat=%3Cproquest_cross%3E1516744814%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1644777808&rft_id=info:pmid/24388009&rft_els_id=1_s2_0_S0091674913017685&rfr_iscdi=true |