Differential effects of the ApoE4 genotype on brain structure and function
The apolipoprotein E ε4 allele is a well established genetic risk factor for sporadic Alzheimer's disease. It is associated with structural and functional brain changes in healthy young, middle-aged and elderly subjects. In the current study, we assessed the impact of the ApoE genotype on brain...
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| Veröffentlicht in: | NeuroImage (Orlando, Fla.) Fla.), 2014-04, Vol.89, p.81-91 |
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| creator | Matura, Silke Prvulovic, David Jurcoane, Alina Hartmann, Daniel Miller, Julia Scheibe, Monika O'Dwyer, Laurence Oertel-Knöchel, Viola Knöchel, Christian Reinke, Britta Karakaya, Tarik Fußer, Fabian Pantel, Johannes |
| description | The apolipoprotein E ε4 allele is a well established genetic risk factor for sporadic Alzheimer's disease. It is associated with structural and functional brain changes in healthy young, middle-aged and elderly subjects. In the current study, we assessed the impact of the ApoE genotype on brain macro- and microstructure, cognitive functioning and brain activity in fifty healthy young subjects (25 ApoE ε4 (ε4+) carriers and 25 non-carriers (ε4−), mean age 26.4±4.6years). We used diffusion tensor imaging (DTI) and voxel based morphometry (VBM) to assess brain structure, an extensive neuropsychological battery to test cognitive functioning and event-related functional magnetic resonance imaging (fMRI) to capture brain activity during episodic memory encoding and retrieval. ApoE ε4 carriers differed from non-carriers in fMRI activations but not in cognitive performance nor in brain micro- and macrostructure. These results suggest functional alterations in the episodic memory network that are modulated by the ε4 allele and might precede clinical or structural neurodegeneration.
•We used a multimodal approach to investigate brain structure and function.•There were memory related alterations in neuronal activations in ApoE4 carriers.•No alterations in brain micro- and macrostructure were found in ApoE4 carriers.•Cognitive performance was equal in ApoE4 carriers and noncarriers. |
| doi_str_mv | 10.1016/j.neuroimage.2013.11.042 |
| format | Article |
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•We used a multimodal approach to investigate brain structure and function.•There were memory related alterations in neuronal activations in ApoE4 carriers.•No alterations in brain micro- and macrostructure were found in ApoE4 carriers.•Cognitive performance was equal in ApoE4 carriers and noncarriers.</description><identifier>ISSN: 1053-8119</identifier><identifier>EISSN: 1095-9572</identifier><identifier>DOI: 10.1016/j.neuroimage.2013.11.042</identifier><identifier>PMID: 24296331</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adult ; Apolipoprotein E4 - genetics ; Apolipoprotein4 ; Biological and medical sciences ; Brain ; Brain - anatomy & histology ; Brain - physiology ; Brain Mapping ; Cognitive ability ; Diffusion Tensor Imaging ; DTI ; Female ; fMRI ; Fundamental and applied biological sciences. Psychology ; Genotype ; Humans ; Magnetic Resonance Imaging ; Male ; Medical imaging ; Memory ; Memory, Episodic ; Neuropsychological Tests ; Studies ; VBM ; Vertebrates: nervous system and sense organs ; Young Adult</subject><ispartof>NeuroImage (Orlando, Fla.), 2014-04, Vol.89, p.81-91</ispartof><rights>2013 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Apr 1, 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-2c4576abac5b2466f64eb4a98f68bb5b459936fb65070c295124856b6c2494c43</citedby><cites>FETCH-LOGICAL-c498t-2c4576abac5b2466f64eb4a98f68bb5b459936fb65070c295124856b6c2494c43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1528366912?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28254966$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24296331$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matura, Silke</creatorcontrib><creatorcontrib>Prvulovic, David</creatorcontrib><creatorcontrib>Jurcoane, Alina</creatorcontrib><creatorcontrib>Hartmann, Daniel</creatorcontrib><creatorcontrib>Miller, Julia</creatorcontrib><creatorcontrib>Scheibe, Monika</creatorcontrib><creatorcontrib>O'Dwyer, Laurence</creatorcontrib><creatorcontrib>Oertel-Knöchel, Viola</creatorcontrib><creatorcontrib>Knöchel, Christian</creatorcontrib><creatorcontrib>Reinke, Britta</creatorcontrib><creatorcontrib>Karakaya, Tarik</creatorcontrib><creatorcontrib>Fußer, Fabian</creatorcontrib><creatorcontrib>Pantel, Johannes</creatorcontrib><title>Differential effects of the ApoE4 genotype on brain structure and function</title><title>NeuroImage (Orlando, Fla.)</title><addtitle>Neuroimage</addtitle><description>The apolipoprotein E ε4 allele is a well established genetic risk factor for sporadic Alzheimer's disease. It is associated with structural and functional brain changes in healthy young, middle-aged and elderly subjects. In the current study, we assessed the impact of the ApoE genotype on brain macro- and microstructure, cognitive functioning and brain activity in fifty healthy young subjects (25 ApoE ε4 (ε4+) carriers and 25 non-carriers (ε4−), mean age 26.4±4.6years). We used diffusion tensor imaging (DTI) and voxel based morphometry (VBM) to assess brain structure, an extensive neuropsychological battery to test cognitive functioning and event-related functional magnetic resonance imaging (fMRI) to capture brain activity during episodic memory encoding and retrieval. ApoE ε4 carriers differed from non-carriers in fMRI activations but not in cognitive performance nor in brain micro- and macrostructure. These results suggest functional alterations in the episodic memory network that are modulated by the ε4 allele and might precede clinical or structural neurodegeneration.
•We used a multimodal approach to investigate brain structure and function.•There were memory related alterations in neuronal activations in ApoE4 carriers.•No alterations in brain micro- and macrostructure were found in ApoE4 carriers.•Cognitive performance was equal in ApoE4 carriers and noncarriers.</description><subject>Adult</subject><subject>Apolipoprotein E4 - genetics</subject><subject>Apolipoprotein4</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain - anatomy & histology</subject><subject>Brain - physiology</subject><subject>Brain Mapping</subject><subject>Cognitive ability</subject><subject>Diffusion Tensor Imaging</subject><subject>DTI</subject><subject>Female</subject><subject>fMRI</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genotype</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Memory</subject><subject>Memory, Episodic</subject><subject>Neuropsychological Tests</subject><subject>Studies</subject><subject>VBM</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Young Adult</subject><issn>1053-8119</issn><issn>1095-9572</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqN0U1vFCEYwPGJ0dha_QqGxJh4mREYeAaOtda3NPGiZwLsQ2UzCyvMmPTby2ZXm3ixJzj8Hl7y7zrC6MAog7fbIeFactzZWxw4ZePA2EAFf9SdM6plr-XEHx_2cuwVY_qse1brllKqmVBPuzMuuIZxZOfdl_cxBCyYlmhngm3vl0pyIMsPJJf7fC3ILaa83O2R5ERcsTGRupTVL2tBYtOGhDX5Jeb0vHsS7FzxxWm96L5_uP529am_-frx89XlTe-FVkvPvZATWGe9dFwABBDohNUqgHJOOiG1HiE4kHSinmvJuFASHHgutPBivOjeHM_dl_xzxbqYXawe59kmzGs1TAKoUUkxPYCOQvGJCv0ASikoyYE3-uofus1rSe3PTXE1Amh2UOqofMm1FgxmX1qwcmcYNYeKZmvuK5pDRcOYaRXb6MvTBavb4ebv4J9sDbw-AVu9nUOxycd67xSXQgM09-7osPX4FbGY6iMmj5tYWmizyfH_r_kNOCW89w</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Matura, Silke</creator><creator>Prvulovic, David</creator><creator>Jurcoane, Alina</creator><creator>Hartmann, Daniel</creator><creator>Miller, Julia</creator><creator>Scheibe, Monika</creator><creator>O'Dwyer, Laurence</creator><creator>Oertel-Knöchel, Viola</creator><creator>Knöchel, Christian</creator><creator>Reinke, Britta</creator><creator>Karakaya, Tarik</creator><creator>Fußer, Fabian</creator><creator>Pantel, Johannes</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>7QO</scope></search><sort><creationdate>20140401</creationdate><title>Differential effects of the ApoE4 genotype on brain structure and function</title><author>Matura, Silke ; Prvulovic, David ; Jurcoane, Alina ; Hartmann, Daniel ; Miller, Julia ; Scheibe, Monika ; O'Dwyer, Laurence ; Oertel-Knöchel, Viola ; Knöchel, Christian ; Reinke, Britta ; Karakaya, Tarik ; Fußer, Fabian ; Pantel, Johannes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-2c4576abac5b2466f64eb4a98f68bb5b459936fb65070c295124856b6c2494c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Apolipoprotein E4 - genetics</topic><topic>Apolipoprotein4</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain - anatomy & histology</topic><topic>Brain - physiology</topic><topic>Brain Mapping</topic><topic>Cognitive ability</topic><topic>Diffusion Tensor Imaging</topic><topic>DTI</topic><topic>Female</topic><topic>fMRI</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genotype</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Memory</topic><topic>Memory, Episodic</topic><topic>Neuropsychological Tests</topic><topic>Studies</topic><topic>VBM</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matura, Silke</creatorcontrib><creatorcontrib>Prvulovic, David</creatorcontrib><creatorcontrib>Jurcoane, Alina</creatorcontrib><creatorcontrib>Hartmann, Daniel</creatorcontrib><creatorcontrib>Miller, Julia</creatorcontrib><creatorcontrib>Scheibe, Monika</creatorcontrib><creatorcontrib>O'Dwyer, Laurence</creatorcontrib><creatorcontrib>Oertel-Knöchel, Viola</creatorcontrib><creatorcontrib>Knöchel, Christian</creatorcontrib><creatorcontrib>Reinke, Britta</creatorcontrib><creatorcontrib>Karakaya, Tarik</creatorcontrib><creatorcontrib>Fußer, Fabian</creatorcontrib><creatorcontrib>Pantel, Johannes</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><jtitle>NeuroImage (Orlando, Fla.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matura, Silke</au><au>Prvulovic, David</au><au>Jurcoane, Alina</au><au>Hartmann, Daniel</au><au>Miller, Julia</au><au>Scheibe, Monika</au><au>O'Dwyer, Laurence</au><au>Oertel-Knöchel, Viola</au><au>Knöchel, Christian</au><au>Reinke, Britta</au><au>Karakaya, Tarik</au><au>Fußer, Fabian</au><au>Pantel, Johannes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential effects of the ApoE4 genotype on brain structure and function</atitle><jtitle>NeuroImage (Orlando, Fla.)</jtitle><addtitle>Neuroimage</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>89</volume><spage>81</spage><epage>91</epage><pages>81-91</pages><issn>1053-8119</issn><eissn>1095-9572</eissn><abstract>The apolipoprotein E ε4 allele is a well established genetic risk factor for sporadic Alzheimer's disease. It is associated with structural and functional brain changes in healthy young, middle-aged and elderly subjects. In the current study, we assessed the impact of the ApoE genotype on brain macro- and microstructure, cognitive functioning and brain activity in fifty healthy young subjects (25 ApoE ε4 (ε4+) carriers and 25 non-carriers (ε4−), mean age 26.4±4.6years). We used diffusion tensor imaging (DTI) and voxel based morphometry (VBM) to assess brain structure, an extensive neuropsychological battery to test cognitive functioning and event-related functional magnetic resonance imaging (fMRI) to capture brain activity during episodic memory encoding and retrieval. ApoE ε4 carriers differed from non-carriers in fMRI activations but not in cognitive performance nor in brain micro- and macrostructure. These results suggest functional alterations in the episodic memory network that are modulated by the ε4 allele and might precede clinical or structural neurodegeneration.
•We used a multimodal approach to investigate brain structure and function.•There were memory related alterations in neuronal activations in ApoE4 carriers.•No alterations in brain micro- and macrostructure were found in ApoE4 carriers.•Cognitive performance was equal in ApoE4 carriers and noncarriers.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>24296331</pmid><doi>10.1016/j.neuroimage.2013.11.042</doi><tpages>11</tpages></addata></record> |
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| subjects | Adult Apolipoprotein E4 - genetics Apolipoprotein4 Biological and medical sciences Brain Brain - anatomy & histology Brain - physiology Brain Mapping Cognitive ability Diffusion Tensor Imaging DTI Female fMRI Fundamental and applied biological sciences. Psychology Genotype Humans Magnetic Resonance Imaging Male Medical imaging Memory Memory, Episodic Neuropsychological Tests Studies VBM Vertebrates: nervous system and sense organs Young Adult |
| title | Differential effects of the ApoE4 genotype on brain structure and function |
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