Significant involvement of herpesvirus entry mediator in human esophageal squamous cell carcinoma
BACKGROUND Herpesvirus entry mediator (HVEM) is known to regulate immune response and to be expressed in several human malignancies. However, to the authors's knowledge, the precise role of HVEM in human cancer biology remains unknown. The objective of the current study was to clarify the clini...
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| Veröffentlicht in: | Cancer 2014-03, Vol.120 (6), p.808-817 |
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| container_title | Cancer |
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| creator | Migita, Kazuhiro Sho, Masayuki Shimada, Keiji Yasuda, Satoshi Yamato, Ichiro Takayama, Tomoyoshi Matsumoto, Sohei Wakatsuki, Kohei Hotta, Kiyohiko Tanaka, Tetsuya Ito, Masahiro Konishi, Noboru Nakajima, Yoshiyuki |
| description | BACKGROUND
Herpesvirus entry mediator (HVEM) is known to regulate immune response and to be expressed in several human malignancies. However, to the authors's knowledge, the precise role of HVEM in human cancer biology remains unknown. The objective of the current study was to clarify the clinical significance of HVEM in human esophageal squamous cell carcinoma as well as its in vivo functions.
METHODS
HVEM expression was evaluated in 103 patients with esophageal squamous cell carcinoma to explore its clinical relevance and prognostic value. The functions of HVEM in tumors were analyzed in vitro and in vivo using the small interfering RNA (siRNA) silencing technique.
RESULTS
HVEM expression was found to be significantly correlated with depth of tumor invasion and lymph node metastasis. Furthermore, it was found to be inversely correlated with tumor‐infiltrating CD4+, CD8+, and CD45RO+ lymphocytes. It is important to note that HVEM status was identified as an independent prognostic marker. HVEM gene silencing significantly inhibited cancer cell proliferation in vitro and cancer growth in vivo. This antitumor effect was associated with reduced cell proliferation activity. The effect was also correlated with the induction of CD8+ cells and upregulation of local immune response.
CONCLUSIONS
HVEM plays a critical role in both tumor progression and the evasion of host antitumor immune responses, possibly through direct and indirect mechanisms. Therefore, HVEM may be a promising therapeutic target for human esophageal cancer. Cancer 2014;120:808–817. © 2013 American Cancer Society.
Herpesvirus entry mediator plays a critical role in both tumor progression and the evasion of host antitumor immune responses in patients with esophageal cancer through direct and indirect mechanisms. Therefore, herpesvirus entry mediator may be a promising therapeutic target for human malignancy. |
| doi_str_mv | 10.1002/cncr.28491 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1566837235</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1504735604</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5381-66bfcd7c4bfc696e6b309364e49a40d316c8c7898af5ce46d92ff243434e5843</originalsourceid><addsrcrecordid>eNqN0EtLAzEQB_AgitbHxQ8gexFEWM17s0cpvkAU1IO3ZZpObGQfNelW-u1NbdWbSA6ThB8zw5-QQ0bPGKX83LY2nHEjS7ZBBoyWRU6Z5JtkQCk1uZLiZYfsxviWngVXYpvscMllqbgZEHjyr6133kI7y3w77-o5NpjuncsmGKYY5z70MUtfYZE1OPYw60KS2aRvoM0wdtMJvCLUWXzvoemStVjXmYVgfds1sE-2HNQRD9Z1jzxfXT4Pb_K7h-vb4cVdbpUwLNd65Oy4sDIVXWrUI0FLoSXKEiQdC6atsYUpDThlUepxyZ3jUqSDykixR05Wbaehe-8xzqrGx-Um0GJaqmJKayMKLtQ_KJWFUJouu56uqA1djAFdNQ2-gbCoGK2W4VfL8Kuv8BM-WvftRympH_qddgLHawDRQu0CtNbHX2cEZQUtkmMr9-FrXPwxshreDx9Xwz8BG3qdPg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1504735604</pqid></control><display><type>article</type><title>Significant involvement of herpesvirus entry mediator in human esophageal squamous cell carcinoma</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Access via Wiley Online Library</source><source>Wiley Online Library (Open Access Collection)</source><source>Alma/SFX Local Collection</source><creator>Migita, Kazuhiro ; Sho, Masayuki ; Shimada, Keiji ; Yasuda, Satoshi ; Yamato, Ichiro ; Takayama, Tomoyoshi ; Matsumoto, Sohei ; Wakatsuki, Kohei ; Hotta, Kiyohiko ; Tanaka, Tetsuya ; Ito, Masahiro ; Konishi, Noboru ; Nakajima, Yoshiyuki</creator><creatorcontrib>Migita, Kazuhiro ; Sho, Masayuki ; Shimada, Keiji ; Yasuda, Satoshi ; Yamato, Ichiro ; Takayama, Tomoyoshi ; Matsumoto, Sohei ; Wakatsuki, Kohei ; Hotta, Kiyohiko ; Tanaka, Tetsuya ; Ito, Masahiro ; Konishi, Noboru ; Nakajima, Yoshiyuki</creatorcontrib><description>BACKGROUND
Herpesvirus entry mediator (HVEM) is known to regulate immune response and to be expressed in several human malignancies. However, to the authors's knowledge, the precise role of HVEM in human cancer biology remains unknown. The objective of the current study was to clarify the clinical significance of HVEM in human esophageal squamous cell carcinoma as well as its in vivo functions.
METHODS
HVEM expression was evaluated in 103 patients with esophageal squamous cell carcinoma to explore its clinical relevance and prognostic value. The functions of HVEM in tumors were analyzed in vitro and in vivo using the small interfering RNA (siRNA) silencing technique.
RESULTS
HVEM expression was found to be significantly correlated with depth of tumor invasion and lymph node metastasis. Furthermore, it was found to be inversely correlated with tumor‐infiltrating CD4+, CD8+, and CD45RO+ lymphocytes. It is important to note that HVEM status was identified as an independent prognostic marker. HVEM gene silencing significantly inhibited cancer cell proliferation in vitro and cancer growth in vivo. This antitumor effect was associated with reduced cell proliferation activity. The effect was also correlated with the induction of CD8+ cells and upregulation of local immune response.
CONCLUSIONS
HVEM plays a critical role in both tumor progression and the evasion of host antitumor immune responses, possibly through direct and indirect mechanisms. Therefore, HVEM may be a promising therapeutic target for human esophageal cancer. Cancer 2014;120:808–817. © 2013 American Cancer Society.
Herpesvirus entry mediator plays a critical role in both tumor progression and the evasion of host antitumor immune responses in patients with esophageal cancer through direct and indirect mechanisms. Therefore, herpesvirus entry mediator may be a promising therapeutic target for human malignancy.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.28491</identifier><identifier>PMID: 24249528</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>Hoboken, NJ: Wiley-Blackwell</publisher><subject>Aged ; Animals ; Biological and medical sciences ; Biomarkers, Tumor - genetics ; Carcinoma, Squamous Cell - genetics ; CD4-Positive T-Lymphocytes - immunology ; CD8-Positive T-Lymphocytes - immunology ; Cell Cycle Checkpoints - genetics ; Cell Line, Tumor ; Cell Proliferation ; Cell Survival - genetics ; Disease Progression ; Esophageal Neoplasms - genetics ; Esophageal Squamous Cell Carcinoma ; Esophagus ; Female ; Forkhead Transcription Factors - biosynthesis ; Gastroenterology. Liver. Pancreas. Abdomen ; Herpesvirus ; herpesvirus entry mediator (HVEM) ; Humans ; immunotherapy ; Leukocyte Common Antigens - biosynthesis ; Lymphatic Metastasis ; Lymphocyte Activation - genetics ; Lymphocyte Activation - immunology ; Male ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Middle Aged ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Neoplasm Invasiveness ; Prognosis ; Receptors, Tumor Necrosis Factor, Member 14 - genetics ; Receptors, Tumor Necrosis Factor, Member 14 - metabolism ; RNA Interference ; RNA, Small Interfering ; Tumors</subject><ispartof>Cancer, 2014-03, Vol.120 (6), p.808-817</ispartof><rights>2013 American Cancer Society</rights><rights>2015 INIST-CNRS</rights><rights>2013 American Cancer Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5381-66bfcd7c4bfc696e6b309364e49a40d316c8c7898af5ce46d92ff243434e5843</citedby><cites>FETCH-LOGICAL-c5381-66bfcd7c4bfc696e6b309364e49a40d316c8c7898af5ce46d92ff243434e5843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcncr.28491$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcncr.28491$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28301707$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24249528$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Migita, Kazuhiro</creatorcontrib><creatorcontrib>Sho, Masayuki</creatorcontrib><creatorcontrib>Shimada, Keiji</creatorcontrib><creatorcontrib>Yasuda, Satoshi</creatorcontrib><creatorcontrib>Yamato, Ichiro</creatorcontrib><creatorcontrib>Takayama, Tomoyoshi</creatorcontrib><creatorcontrib>Matsumoto, Sohei</creatorcontrib><creatorcontrib>Wakatsuki, Kohei</creatorcontrib><creatorcontrib>Hotta, Kiyohiko</creatorcontrib><creatorcontrib>Tanaka, Tetsuya</creatorcontrib><creatorcontrib>Ito, Masahiro</creatorcontrib><creatorcontrib>Konishi, Noboru</creatorcontrib><creatorcontrib>Nakajima, Yoshiyuki</creatorcontrib><title>Significant involvement of herpesvirus entry mediator in human esophageal squamous cell carcinoma</title><title>Cancer</title><addtitle>Cancer</addtitle><description>BACKGROUND
Herpesvirus entry mediator (HVEM) is known to regulate immune response and to be expressed in several human malignancies. However, to the authors's knowledge, the precise role of HVEM in human cancer biology remains unknown. The objective of the current study was to clarify the clinical significance of HVEM in human esophageal squamous cell carcinoma as well as its in vivo functions.
METHODS
HVEM expression was evaluated in 103 patients with esophageal squamous cell carcinoma to explore its clinical relevance and prognostic value. The functions of HVEM in tumors were analyzed in vitro and in vivo using the small interfering RNA (siRNA) silencing technique.
RESULTS
HVEM expression was found to be significantly correlated with depth of tumor invasion and lymph node metastasis. Furthermore, it was found to be inversely correlated with tumor‐infiltrating CD4+, CD8+, and CD45RO+ lymphocytes. It is important to note that HVEM status was identified as an independent prognostic marker. HVEM gene silencing significantly inhibited cancer cell proliferation in vitro and cancer growth in vivo. This antitumor effect was associated with reduced cell proliferation activity. The effect was also correlated with the induction of CD8+ cells and upregulation of local immune response.
CONCLUSIONS
HVEM plays a critical role in both tumor progression and the evasion of host antitumor immune responses, possibly through direct and indirect mechanisms. Therefore, HVEM may be a promising therapeutic target for human esophageal cancer. Cancer 2014;120:808–817. © 2013 American Cancer Society.
Herpesvirus entry mediator plays a critical role in both tumor progression and the evasion of host antitumor immune responses in patients with esophageal cancer through direct and indirect mechanisms. Therefore, herpesvirus entry mediator may be a promising therapeutic target for human malignancy.</description><subject>Aged</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>Cell Cycle Checkpoints - genetics</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation</subject><subject>Cell Survival - genetics</subject><subject>Disease Progression</subject><subject>Esophageal Neoplasms - genetics</subject><subject>Esophageal Squamous Cell Carcinoma</subject><subject>Esophagus</subject><subject>Female</subject><subject>Forkhead Transcription Factors - biosynthesis</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Herpesvirus</subject><subject>herpesvirus entry mediator (HVEM)</subject><subject>Humans</subject><subject>immunotherapy</subject><subject>Leukocyte Common Antigens - biosynthesis</subject><subject>Lymphatic Metastasis</subject><subject>Lymphocyte Activation - genetics</subject><subject>Lymphocyte Activation - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Middle Aged</subject><subject>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</subject><subject>Neoplasm Invasiveness</subject><subject>Prognosis</subject><subject>Receptors, Tumor Necrosis Factor, Member 14 - genetics</subject><subject>Receptors, Tumor Necrosis Factor, Member 14 - metabolism</subject><subject>RNA Interference</subject><subject>RNA, Small Interfering</subject><subject>Tumors</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0EtLAzEQB_AgitbHxQ8gexFEWM17s0cpvkAU1IO3ZZpObGQfNelW-u1NbdWbSA6ThB8zw5-QQ0bPGKX83LY2nHEjS7ZBBoyWRU6Z5JtkQCk1uZLiZYfsxviWngVXYpvscMllqbgZEHjyr6133kI7y3w77-o5NpjuncsmGKYY5z70MUtfYZE1OPYw60KS2aRvoM0wdtMJvCLUWXzvoemStVjXmYVgfds1sE-2HNQRD9Z1jzxfXT4Pb_K7h-vb4cVdbpUwLNd65Oy4sDIVXWrUI0FLoSXKEiQdC6atsYUpDThlUepxyZ3jUqSDykixR05Wbaehe-8xzqrGx-Um0GJaqmJKayMKLtQ_KJWFUJouu56uqA1djAFdNQ2-gbCoGK2W4VfL8Kuv8BM-WvftRympH_qddgLHawDRQu0CtNbHX2cEZQUtkmMr9-FrXPwxshreDx9Xwz8BG3qdPg</recordid><startdate>20140315</startdate><enddate>20140315</enddate><creator>Migita, Kazuhiro</creator><creator>Sho, Masayuki</creator><creator>Shimada, Keiji</creator><creator>Yasuda, Satoshi</creator><creator>Yamato, Ichiro</creator><creator>Takayama, Tomoyoshi</creator><creator>Matsumoto, Sohei</creator><creator>Wakatsuki, Kohei</creator><creator>Hotta, Kiyohiko</creator><creator>Tanaka, Tetsuya</creator><creator>Ito, Masahiro</creator><creator>Konishi, Noboru</creator><creator>Nakajima, Yoshiyuki</creator><general>Wiley-Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>20140315</creationdate><title>Significant involvement of herpesvirus entry mediator in human esophageal squamous cell carcinoma</title><author>Migita, Kazuhiro ; Sho, Masayuki ; Shimada, Keiji ; Yasuda, Satoshi ; Yamato, Ichiro ; Takayama, Tomoyoshi ; Matsumoto, Sohei ; Wakatsuki, Kohei ; Hotta, Kiyohiko ; Tanaka, Tetsuya ; Ito, Masahiro ; Konishi, Noboru ; Nakajima, Yoshiyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5381-66bfcd7c4bfc696e6b309364e49a40d316c8c7898af5ce46d92ff243434e5843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>Cell Cycle Checkpoints - genetics</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation</topic><topic>Cell Survival - genetics</topic><topic>Disease Progression</topic><topic>Esophageal Neoplasms - genetics</topic><topic>Esophageal Squamous Cell Carcinoma</topic><topic>Esophagus</topic><topic>Female</topic><topic>Forkhead Transcription Factors - biosynthesis</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Herpesvirus</topic><topic>herpesvirus entry mediator (HVEM)</topic><topic>Humans</topic><topic>immunotherapy</topic><topic>Leukocyte Common Antigens - biosynthesis</topic><topic>Lymphatic Metastasis</topic><topic>Lymphocyte Activation - genetics</topic><topic>Lymphocyte Activation - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Middle Aged</topic><topic>Multiple tumors. Solid tumors. Tumors in childhood (general aspects)</topic><topic>Neoplasm Invasiveness</topic><topic>Prognosis</topic><topic>Receptors, Tumor Necrosis Factor, Member 14 - genetics</topic><topic>Receptors, Tumor Necrosis Factor, Member 14 - metabolism</topic><topic>RNA Interference</topic><topic>RNA, Small Interfering</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Migita, Kazuhiro</creatorcontrib><creatorcontrib>Sho, Masayuki</creatorcontrib><creatorcontrib>Shimada, Keiji</creatorcontrib><creatorcontrib>Yasuda, Satoshi</creatorcontrib><creatorcontrib>Yamato, Ichiro</creatorcontrib><creatorcontrib>Takayama, Tomoyoshi</creatorcontrib><creatorcontrib>Matsumoto, Sohei</creatorcontrib><creatorcontrib>Wakatsuki, Kohei</creatorcontrib><creatorcontrib>Hotta, Kiyohiko</creatorcontrib><creatorcontrib>Tanaka, Tetsuya</creatorcontrib><creatorcontrib>Ito, Masahiro</creatorcontrib><creatorcontrib>Konishi, Noboru</creatorcontrib><creatorcontrib>Nakajima, Yoshiyuki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Migita, Kazuhiro</au><au>Sho, Masayuki</au><au>Shimada, Keiji</au><au>Yasuda, Satoshi</au><au>Yamato, Ichiro</au><au>Takayama, Tomoyoshi</au><au>Matsumoto, Sohei</au><au>Wakatsuki, Kohei</au><au>Hotta, Kiyohiko</au><au>Tanaka, Tetsuya</au><au>Ito, Masahiro</au><au>Konishi, Noboru</au><au>Nakajima, Yoshiyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Significant involvement of herpesvirus entry mediator in human esophageal squamous cell carcinoma</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2014-03-15</date><risdate>2014</risdate><volume>120</volume><issue>6</issue><spage>808</spage><epage>817</epage><pages>808-817</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>BACKGROUND
Herpesvirus entry mediator (HVEM) is known to regulate immune response and to be expressed in several human malignancies. However, to the authors's knowledge, the precise role of HVEM in human cancer biology remains unknown. The objective of the current study was to clarify the clinical significance of HVEM in human esophageal squamous cell carcinoma as well as its in vivo functions.
METHODS
HVEM expression was evaluated in 103 patients with esophageal squamous cell carcinoma to explore its clinical relevance and prognostic value. The functions of HVEM in tumors were analyzed in vitro and in vivo using the small interfering RNA (siRNA) silencing technique.
RESULTS
HVEM expression was found to be significantly correlated with depth of tumor invasion and lymph node metastasis. Furthermore, it was found to be inversely correlated with tumor‐infiltrating CD4+, CD8+, and CD45RO+ lymphocytes. It is important to note that HVEM status was identified as an independent prognostic marker. HVEM gene silencing significantly inhibited cancer cell proliferation in vitro and cancer growth in vivo. This antitumor effect was associated with reduced cell proliferation activity. The effect was also correlated with the induction of CD8+ cells and upregulation of local immune response.
CONCLUSIONS
HVEM plays a critical role in both tumor progression and the evasion of host antitumor immune responses, possibly through direct and indirect mechanisms. Therefore, HVEM may be a promising therapeutic target for human esophageal cancer. Cancer 2014;120:808–817. © 2013 American Cancer Society.
Herpesvirus entry mediator plays a critical role in both tumor progression and the evasion of host antitumor immune responses in patients with esophageal cancer through direct and indirect mechanisms. Therefore, herpesvirus entry mediator may be a promising therapeutic target for human malignancy.</abstract><cop>Hoboken, NJ</cop><pub>Wiley-Blackwell</pub><pmid>24249528</pmid><doi>10.1002/cncr.28491</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancer, 2014-03, Vol.120 (6), p.808-817 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Access via Wiley Online Library; Wiley Online Library (Open Access Collection); Alma/SFX Local Collection |
| subjects | Aged Animals Biological and medical sciences Biomarkers, Tumor - genetics Carcinoma, Squamous Cell - genetics CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Cell Cycle Checkpoints - genetics Cell Line, Tumor Cell Proliferation Cell Survival - genetics Disease Progression Esophageal Neoplasms - genetics Esophageal Squamous Cell Carcinoma Esophagus Female Forkhead Transcription Factors - biosynthesis Gastroenterology. Liver. Pancreas. Abdomen Herpesvirus herpesvirus entry mediator (HVEM) Humans immunotherapy Leukocyte Common Antigens - biosynthesis Lymphatic Metastasis Lymphocyte Activation - genetics Lymphocyte Activation - immunology Male Medical sciences Mice Mice, Inbred BALB C Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasm Invasiveness Prognosis Receptors, Tumor Necrosis Factor, Member 14 - genetics Receptors, Tumor Necrosis Factor, Member 14 - metabolism RNA Interference RNA, Small Interfering Tumors |
| title | Significant involvement of herpesvirus entry mediator in human esophageal squamous cell carcinoma |
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