Expanding and Reprogramming the Genetic Code of Cells and Animals

Genetic code expansion and reprogramming enable the site-specific incorporation of diverse designer amino acids into proteins produced in cells and animals. Recent advances are enhancing the efficiency of unnatural amino acid incorporation by creating and evolving orthogonal ribosomes and manipulati...

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Veröffentlicht in:	Annual review of biochemistry 2014-01, Vol.83 (1), p.379-408
1. Verfasser:	Chin, Jason W
Format:	Artikel
Sprache:	eng
Schlagworte:	amino acid Amino acids Amino Acids - chemistry Amino Acyl-tRNA Synthetases - chemistry aminoacyl-tRNA synthetase Animals Biochemistry bioorthogonal reaction Caenorhabditis elegans Drosophila melanogaster Escherichia coli - genetics Evolution, Molecular Gene Deletion Genetic Code genetic code expansion Genetics Genome posttranslational modification protein chemistry Protein Engineering - methods protein labeling Proteins ribosome Ribosomes - chemistry RNA, Transfer - chemistry Saccharomyces cerevisiae - genetics synthetic biology Transfer RNA tRNA
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