A personalized view on cancer immunotherapy

A personalized view on cancer immunotherapy

Highlights • Tumor antigens are the key to effective immunotherapy. • An overview of the current state-of-the-art in cancer immunotherapy is provided. • Immunotherapeutic advances, immune reaction differences and tumor heterogeneity augment the need for predictive biomarkers. • The implementation of...

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Veröffentlicht in:Cancer letters 2014-09, Vol.352 (1), p.113-125
Hauptverfasser: Wayteck, Laura, Breckpot, Karine, Demeester, Jo, De Smedt, Stefaan C, Raemdonck, Koen
Format: Artikel
Sprache:eng
Schlagworte:
Adoptive T cell therapy
Breast cancer
Cancer immunotherapy
Cancer therapies
Cancer Vaccines - therapeutic use
Cell growth
Genes
Hematology, Oncology and Palliative Medicine
Humans
Immune system
Immunotherapy
Kinases
Medical research
Mutation
Neoplasms - therapy
Personalized medicine
Precision Medicine
Predictive biomarkers
Tumor antigens
Tumor heterogeneity
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Beschreibung
Zusammenfassung:Highlights • Tumor antigens are the key to effective immunotherapy. • An overview of the current state-of-the-art in cancer immunotherapy is provided. • Immunotherapeutic advances, immune reaction differences and tumor heterogeneity augment the need for predictive biomarkers. • The implementation of a personalized approach in cancer immunotherapy to improve safety and clinical outcome is highlighted.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2013.09.016