Lanthanum carbonate stimulates bone formation in a rat model of renal insufficiency with low bone turnover
Control of phosphate is important in the management of chronic kidney disease with mineral and bone disorder (CKD-MBD), for which lanthanum carbonate, a non-calcium phosphate-binding agent, has recently been introduced; however, it remains to be determined whether it has any beneficial or deleteriou...
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| Veröffentlicht in: | Journal of bone and mineral metabolism 2014-09, Vol.32 (5), p.484-493 |
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| creator | Fumoto, Toshio Ito, Masako Ikeda, Kyoji |
| description | Control of phosphate is important in the management of chronic kidney disease with mineral and bone disorder (CKD-MBD), for which lanthanum carbonate, a non-calcium phosphate-binding agent, has recently been introduced; however, it remains to be determined whether it has any beneficial or deleterious effect on bone remodeling. In the present study, the effects of lanthanum carbonate were examined in an animal model that mimics low turnover bone disease in CKD, i.e., thyroparathyroidectomized (TPTX) and 5/6 nephrectomized (NX) rats undergoing a constant infusion of parathyroid hormone (PTH) and thyroxine injections (TPTX-PTH-5/6NX). Bone histomorphometry at the second lumbar vertebra and tibial metaphysis revealed that both bone formation and resorption were markedly suppressed in the TPTX-PTH-5/6NX model compared with the sham-operated control group, and treatment with lanthanum carbonate was associated with the stimulation of bone formation but not an acceleration of bone resorption. Lanthanum treatment caused a robust stimulation of bone formation with an activation of osteoblasts on the endosteal surface of femoral diaphysis, leading to an increase in cortical bone volume. Thus, lanthanum carbonate has the potential to stimulate bone formation in cases of CKD-MBD with suppressed bone turnover. |
| doi_str_mv | 10.1007/s00774-013-0521-2 |
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In the present study, the effects of lanthanum carbonate were examined in an animal model that mimics low turnover bone disease in CKD, i.e., thyroparathyroidectomized (TPTX) and 5/6 nephrectomized (NX) rats undergoing a constant infusion of parathyroid hormone (PTH) and thyroxine injections (TPTX-PTH-5/6NX). Bone histomorphometry at the second lumbar vertebra and tibial metaphysis revealed that both bone formation and resorption were markedly suppressed in the TPTX-PTH-5/6NX model compared with the sham-operated control group, and treatment with lanthanum carbonate was associated with the stimulation of bone formation but not an acceleration of bone resorption. Lanthanum treatment caused a robust stimulation of bone formation with an activation of osteoblasts on the endosteal surface of femoral diaphysis, leading to an increase in cortical bone volume. 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In the present study, the effects of lanthanum carbonate were examined in an animal model that mimics low turnover bone disease in CKD, i.e., thyroparathyroidectomized (TPTX) and 5/6 nephrectomized (NX) rats undergoing a constant infusion of parathyroid hormone (PTH) and thyroxine injections (TPTX-PTH-5/6NX). Bone histomorphometry at the second lumbar vertebra and tibial metaphysis revealed that both bone formation and resorption were markedly suppressed in the TPTX-PTH-5/6NX model compared with the sham-operated control group, and treatment with lanthanum carbonate was associated with the stimulation of bone formation but not an acceleration of bone resorption. Lanthanum treatment caused a robust stimulation of bone formation with an activation of osteoblasts on the endosteal surface of femoral diaphysis, leading to an increase in cortical bone volume. Thus, lanthanum carbonate has the potential to stimulate bone formation in cases of CKD-MBD with suppressed bone turnover.</description><subject>Alkaline Phosphatase - metabolism</subject><subject>Animals</subject><subject>Body Weight - drug effects</subject><subject>Bone Morphogenetic Proteins - metabolism</subject><subject>Bone Remodeling - drug effects</subject><subject>Cell Count</subject><subject>Disease Models, Animal</subject><subject>Femur - diagnostic imaging</subject><subject>Femur - drug effects</subject><subject>Femur - physiopathology</subject><subject>Genetic Markers</subject><subject>Lanthanum - pharmacology</subject><subject>Lumbar Vertebrae - drug effects</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Osteocytes - pathology</subject><subject>Osteogenesis - drug effects</subject><subject>Rats, Sprague-Dawley</subject><subject>Renal Insufficiency - blood</subject><subject>Renal Insufficiency - physiopathology</subject><subject>Tibia - diagnostic imaging</subject><subject>Tibia - drug effects</subject><subject>Tibia - physiopathology</subject><subject>X-Ray Microtomography</subject><issn>0914-8779</issn><issn>1435-5604</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkU1rFTEUhoMo9rb6A9xIwI2b0Zx8z1JKtcIFN7oOmUxi5zKT1CRj6b8341QRQXCThJPnvMnhQegFkDdAiHpb2qJ4R4B1RFDo6CN0AM5EJyThj9GB9MA7rVR_hs5LORECSih4is4oByplzw_odLSx3ti4LtjZPKRoq8elTss6t1PBreJxSHmxdUoRTxFbnG3FSxr9jFPA2Uc7t3pZQ5jc5KO7x3dTvcFzutu765pj-u7zM_Qk2Ln45w_7Bfry_urz5XV3_PTh4-W7Y-c47WtH-3EAcLp3CgbZaw0Qxl5qN1KppFSD5E74kY0uSGDARssZIxCs41pbS9kFer3n3ub0bfWlmmUqzs-zjT6txYCQUjPBBfsflAjNKWzoq7_QU2qDtUF-UoxJRjYKdsrlVEr2wdzmabH53gAxmzOzOzPNmdmcme2_Lx-S12Hx4--OX5IaQHegtKv41ec_nv5n6g_sn6E0</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Fumoto, Toshio</creator><creator>Ito, Masako</creator><creator>Ikeda, Kyoji</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20140901</creationdate><title>Lanthanum carbonate stimulates bone formation in a rat model of renal insufficiency with low bone turnover</title><author>Fumoto, Toshio ; Ito, Masako ; Ikeda, Kyoji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-29db11c89c71b698811fd968cd267667b64c5ed3dcf61313da43301fac488aa23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Alkaline Phosphatase - metabolism</topic><topic>Animals</topic><topic>Body Weight - drug effects</topic><topic>Bone Morphogenetic Proteins - metabolism</topic><topic>Bone Remodeling - drug effects</topic><topic>Cell Count</topic><topic>Disease Models, Animal</topic><topic>Femur - diagnostic imaging</topic><topic>Femur - drug effects</topic><topic>Femur - physiopathology</topic><topic>Genetic Markers</topic><topic>Lanthanum - pharmacology</topic><topic>Lumbar Vertebrae - drug effects</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Osteocytes - pathology</topic><topic>Osteogenesis - drug effects</topic><topic>Rats, Sprague-Dawley</topic><topic>Renal Insufficiency - blood</topic><topic>Renal Insufficiency - physiopathology</topic><topic>Tibia - diagnostic imaging</topic><topic>Tibia - drug effects</topic><topic>Tibia - physiopathology</topic><topic>X-Ray Microtomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fumoto, Toshio</creatorcontrib><creatorcontrib>Ito, Masako</creatorcontrib><creatorcontrib>Ikeda, Kyoji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of bone and mineral metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fumoto, Toshio</au><au>Ito, Masako</au><au>Ikeda, Kyoji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lanthanum carbonate stimulates bone formation in a rat model of renal insufficiency with low bone turnover</atitle><jtitle>Journal of bone and mineral metabolism</jtitle><stitle>J Bone Miner Metab</stitle><addtitle>J Bone Miner Metab</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>32</volume><issue>5</issue><spage>484</spage><epage>493</epage><pages>484-493</pages><issn>0914-8779</issn><eissn>1435-5604</eissn><abstract>Control of phosphate is important in the management of chronic kidney disease with mineral and bone disorder (CKD-MBD), for which lanthanum carbonate, a non-calcium phosphate-binding agent, has recently been introduced; however, it remains to be determined whether it has any beneficial or deleterious effect on bone remodeling. In the present study, the effects of lanthanum carbonate were examined in an animal model that mimics low turnover bone disease in CKD, i.e., thyroparathyroidectomized (TPTX) and 5/6 nephrectomized (NX) rats undergoing a constant infusion of parathyroid hormone (PTH) and thyroxine injections (TPTX-PTH-5/6NX). Bone histomorphometry at the second lumbar vertebra and tibial metaphysis revealed that both bone formation and resorption were markedly suppressed in the TPTX-PTH-5/6NX model compared with the sham-operated control group, and treatment with lanthanum carbonate was associated with the stimulation of bone formation but not an acceleration of bone resorption. Lanthanum treatment caused a robust stimulation of bone formation with an activation of osteoblasts on the endosteal surface of femoral diaphysis, leading to an increase in cortical bone volume. Thus, lanthanum carbonate has the potential to stimulate bone formation in cases of CKD-MBD with suppressed bone turnover.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>24126694</pmid><doi>10.1007/s00774-013-0521-2</doi><tpages>10</tpages></addata></record> |
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| ispartof | Journal of bone and mineral metabolism, 2014-09, Vol.32 (5), p.484-493 |
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| subjects | Alkaline Phosphatase - metabolism Animals Body Weight - drug effects Bone Morphogenetic Proteins - metabolism Bone Remodeling - drug effects Cell Count Disease Models, Animal Femur - diagnostic imaging Femur - drug effects Femur - physiopathology Genetic Markers Lanthanum - pharmacology Lumbar Vertebrae - drug effects Male Medicine Medicine & Public Health Metabolic Diseases Original Article Orthopedics Osteocytes - pathology Osteogenesis - drug effects Rats, Sprague-Dawley Renal Insufficiency - blood Renal Insufficiency - physiopathology Tibia - diagnostic imaging Tibia - drug effects Tibia - physiopathology X-Ray Microtomography |
| title | Lanthanum carbonate stimulates bone formation in a rat model of renal insufficiency with low bone turnover |
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