Type I interferons have opposing effects during the emergence and recovery phases of colitis

The contribution of the innate immune system to inflammatory bowel disease (IBD) is under intensive investigation. Research in animal models has demonstrated that type I interferons (IFN‐Is) protect from IBD. In contrast, studies of patients with IBD have produced conflicting results concerning the...

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Veröffentlicht in:	European journal of immunology 2014-09, Vol.44 (9), p.2749-2760
Hauptverfasser:	Rauch, Isabella, Hainzl, Eva, Rosebrock, Felix, Heider, Susanne, Schwab, Clarissa, Berry, David, Stoiber, Dagmar, Wagner, Michael, Schleper, Christa, Loy, Alexander, Urich, Tim, Müller, Mathias, Strobl, Birgit, Kenner, Lukas, Decker, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Colitis Colitis - chemically induced Colitis - genetics Colitis - immunology Colitis - pathology Dextran Sulfate - toxicity Histocompatibility Antigens Class II - genetics Histocompatibility Antigens Class II - immunology Inflammation Inflammation - chemically induced Inflammation - genetics Inflammation - immunology Inflammation - pathology Inflammatory Bowel Diseases - chemically induced Inflammatory Bowel Diseases - genetics Inflammatory Bowel Diseases - immunology Inflammatory Bowel Diseases - pathology Interferon Type I - genetics Interferon Type I - immunology Interferons Interleukin-1beta - genetics Interleukin-1beta - immunology Interleukin‐1 Intestines - immunology Intestines - pathology Macrophages - immunology Macrophages - pathology Mice Mice, Knockout Microbiota Neutrophil Infiltration - drug effects Neutrophil Infiltration - genetics Neutrophil Infiltration - immunology Neutrophils - immunology Neutrophils - pathology
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