Generalized urticaria induced by the Na -ASP-2 hookworm vaccine: Implications for the development of vaccines against helminths

Background Necator americanus Ancylostoma-secreted protein 2 ( Na -ASP-2) is secreted by infective hookworm larvae on entry into human hosts. Vaccination of laboratory animals with recombinant Na -ASP-2 provides significant protection against challenge infections. In endemic areas antibodies to Na -...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2012-07, Vol.130 (1), p.169-176.e6
Hauptverfasser:	Diemert, David J., MD, FRCP(C), Pinto, Antonio G., MD, Freire, Janaina, MD, Jariwala, Amar, MD, Santiago, Helton, MD, PhD, Hamilton, Robert G., PhD, Periago, Maria Victoria, PhD, Loukas, Alex, PhD, Tribolet, Leon, BSc, Mulvenna, Jason, PhD, Correa-Oliveira, Rodrigo, PhD, Hotez, Peter J., MD, PhD, Bethony, Jeffrey M., PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Allergic diseases Allergy and Immunology Ancylostomiases Animals Antigens, Helminth - administration & dosage Antigens, Helminth - adverse effects Antigens, Helminth - immunology Biological and medical sciences Brazil Brazil - epidemiology Diseases caused by nematodes Drug dosages Epitope Mapping Female Fundamental and applied biological sciences. Psychology Fundamental immunology Helminth Proteins - administration & dosage Helminth Proteins - adverse effects Helminth Proteins - immunology Helminthic diseases Hepatitis Hepatitis B virus Hookworm Humans IgE Immunization Immunoglobulin E - blood Immunoglobulin G - blood Immunopathology Infectious diseases Male Medical sciences Middle Aged Na-ASP-2 Necator americanus Necator americanus - immunology Necatoriasis - epidemiology Necatoriasis - immunology Necatoriasis - prevention & control Parasitic diseases Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Seroepidemiologic Studies Skin allergic diseases. Stinging insect allergies Studies Treatment Outcome urticaria Urticaria - epidemiology Urticaria - etiology Vaccination - adverse effects vaccine Vaccines Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - adverse effects Vaccines, Synthetic - immunology Young Adult
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