Serum 25-hydroxyvitamin D below 25 ng/mL is a risk factor for long bone fracture comparable to bone mineral density in Japanese postmenopausal women
There is emergent evidence for divergent associations between 25(OH)D levels and fractures by race and ethnicity, but data on Asian populations are sparse. We investigated this association in a primary care cohort of 1470 postmenopausal Japanese women followed for a mean period of 7.2 years and expl...
Gespeichert in:
| Veröffentlicht in: | Journal of bone and mineral metabolism 2014-09, Vol.32 (5), p.514-523 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 523 |
|---|---|
| container_issue | 5 |
| container_start_page | 514 |
| container_title | Journal of bone and mineral metabolism |
| container_volume | 32 |
| creator | Tanaka, Shiro Kuroda, Tatsuhiko Yamazaki, Yasushi Shiraki, Yumiko Yoshimura, Noriko Shiraki, Masataka |
| description | There is emergent evidence for divergent associations between 25(OH)D levels and fractures by race and ethnicity, but data on Asian populations are sparse. We investigated this association in a primary care cohort of 1470 postmenopausal Japanese women followed for a mean period of 7.2 years and explored a potential threshold of 25(OH)D. Endpoints were incident vertebral, proximal femur, and long bone fractures. Rate ratios were estimated using multivariate Poisson regression adjusted for lumbar or femur bone mineral density (BMD) less than −2.5 SD of the young adult mean (YAM), age, weight, presence of diabetes mellitus, parathyroid hormone, estimated glomerular filtration rate, prior fracture, back pain, present medications and past medical history. Mean age was 63.7 ± 10.7 years and osteoporosis patients were 41.3 %. The background data of the present participants were almost identical to the subjects participating in the National Health and Nutrition Survey of 2003. Overall, 49.6 % of the subjects had a 25(OH)D value |
| doi_str_mv | 10.1007/s00774-013-0520-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1566832638</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1566832638</sourcerecordid><originalsourceid>FETCH-LOGICAL-c495t-a19a2dd2378e225bb985c149add9399964db061cdab7db924decba2cee8f8efd3</originalsourceid><addsrcrecordid>eNqNkUuO1TAQRS0Eoh8NC2CCLDFhYtrfJB6i5q8nMQDGlj-VR5rEDnZC8xbCnLWwMtykQQgJiYFtle-pa5cuQvcZfcwobc9K3VpJKBOEKk6JuIF2TApFVEPlTbSjmknSta0-QXdKuaCUtaplt9EJl7RhSrId-voW8jphrsiHY8jpy_HzsNhpiPgpdjCmy6p8_xYPZ9MeDwVbnIfyEffWLynjvq4xxQN2KQLuc71dM2Cfptlm60bAS9q0agjZjjhALMNyxNX_tZ1thAJ4TmWZIKbZrqUil6kWd9Gt3o4F7l2fp-j982fvzl-S_ZsXr86f7ImXWi3EMm15CFy0HXCunNOd8kxqG4IWWutGBlcH9cG6NjjNZQDvLPcAXd9BH8QperT5zjl9WqEsZhqKh3GsX0trMUw1TSd4I7r_QanqZNPQij78C71Ia451kJ-UENVPV4ptlM-plAy9mfMw2Xw0jJqreM0Wr6nxmqt4jag9D66dVzdB-N3xK88K8A0oVYoHyH88_U_XH3yGshk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1560336389</pqid></control><display><type>article</type><title>Serum 25-hydroxyvitamin D below 25 ng/mL is a risk factor for long bone fracture comparable to bone mineral density in Japanese postmenopausal women</title><source>MEDLINE</source><source>SpringerLink (Online service)</source><creator>Tanaka, Shiro ; Kuroda, Tatsuhiko ; Yamazaki, Yasushi ; Shiraki, Yumiko ; Yoshimura, Noriko ; Shiraki, Masataka</creator><creatorcontrib>Tanaka, Shiro ; Kuroda, Tatsuhiko ; Yamazaki, Yasushi ; Shiraki, Yumiko ; Yoshimura, Noriko ; Shiraki, Masataka</creatorcontrib><description>There is emergent evidence for divergent associations between 25(OH)D levels and fractures by race and ethnicity, but data on Asian populations are sparse. We investigated this association in a primary care cohort of 1470 postmenopausal Japanese women followed for a mean period of 7.2 years and explored a potential threshold of 25(OH)D. Endpoints were incident vertebral, proximal femur, and long bone fractures. Rate ratios were estimated using multivariate Poisson regression adjusted for lumbar or femur bone mineral density (BMD) less than −2.5 SD of the young adult mean (YAM), age, weight, presence of diabetes mellitus, parathyroid hormone, estimated glomerular filtration rate, prior fracture, back pain, present medications and past medical history. Mean age was 63.7 ± 10.7 years and osteoporosis patients were 41.3 %. The background data of the present participants were almost identical to the subjects participating in the National Health and Nutrition Survey of 2003. Overall, 49.6 % of the subjects had a 25(OH)D value <20 ng/mL and 27.8 % had a 25(OH)D value from 20 to 24 ng/mL. The propensity score for exposure to 25(OH)D < 25 ng/mL in the present and independent community dwelling populations, namely the Miyama and Taiji cohorts, were not significantly different, suggesting no evidence for selection bias. The generalized additive models showed clear decreasing trends in incidence rates of proximal femur and long bone fractures at higher levels of 25(OH)D, and the annual incidence rate of proximal femur fracture was around 0.0005 in women with 25(OH)D > 25 ng/mL, probably leading to the decreasing trend in long bone fracture. Multivariate-adjusted rate ratios of 25(OH)D < 25 ng/mL were 1.01 (95 % confidence interval [CI], 0.84–1.22,
p
= 0.88) for vertebral fracture, 2.71 (95 % CI 0.94–7.83,
p
= 0.07) for proximal femur fracture, and 2.20 (95 % CI 1.37–3.53,
p
< 0.01) for long bone fracture. The respective rate ratios of a BMD level lower than −2.5 SD of the YAM were 1.61 (95 % CI 1.33–1.94,
p
< 0.01), 1.52 (95 % CI 0.67–3.45,
p
= 0.32), and 1.54 (95 % CI 1.02–2.33,
p
= 0.04). In conclusion, 25(OH)D is a leading risk factor for long bone fracture comparable to BMD in Japanese postmenopausal women. The contribution of 25(OH)D to fracture risks is substantial even below 25 ng/mL and is possibly site-specific. We recommend measuring the serum 25(OH)D level in primary care settings.</description><identifier>ISSN: 0914-8779</identifier><identifier>EISSN: 1435-5604</identifier><identifier>DOI: 10.1007/s00774-013-0520-3</identifier><identifier>PMID: 24061541</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Adult ; Aged ; Asian Continental Ancestry Group ; Bone Density ; Confidence Intervals ; Female ; Fractures, Bone - blood ; Fractures, Bone - epidemiology ; Fractures, Bone - physiopathology ; Humans ; Japan - epidemiology ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Nutrition Surveys ; Original Article ; Orthopedics ; Postmenopause - blood ; Risk Factors ; Vitamin D - analogs & derivatives ; Vitamin D - blood</subject><ispartof>Journal of bone and mineral metabolism, 2014-09, Vol.32 (5), p.514-523</ispartof><rights>The Japanese Society for Bone and Mineral Research and Springer Japan 2013</rights><rights>The Japanese Society for Bone and Mineral Research and Springer Japan 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-a19a2dd2378e225bb985c149add9399964db061cdab7db924decba2cee8f8efd3</citedby><cites>FETCH-LOGICAL-c495t-a19a2dd2378e225bb985c149add9399964db061cdab7db924decba2cee8f8efd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00774-013-0520-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00774-013-0520-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24061541$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanaka, Shiro</creatorcontrib><creatorcontrib>Kuroda, Tatsuhiko</creatorcontrib><creatorcontrib>Yamazaki, Yasushi</creatorcontrib><creatorcontrib>Shiraki, Yumiko</creatorcontrib><creatorcontrib>Yoshimura, Noriko</creatorcontrib><creatorcontrib>Shiraki, Masataka</creatorcontrib><title>Serum 25-hydroxyvitamin D below 25 ng/mL is a risk factor for long bone fracture comparable to bone mineral density in Japanese postmenopausal women</title><title>Journal of bone and mineral metabolism</title><addtitle>J Bone Miner Metab</addtitle><addtitle>J Bone Miner Metab</addtitle><description>There is emergent evidence for divergent associations between 25(OH)D levels and fractures by race and ethnicity, but data on Asian populations are sparse. We investigated this association in a primary care cohort of 1470 postmenopausal Japanese women followed for a mean period of 7.2 years and explored a potential threshold of 25(OH)D. Endpoints were incident vertebral, proximal femur, and long bone fractures. Rate ratios were estimated using multivariate Poisson regression adjusted for lumbar or femur bone mineral density (BMD) less than −2.5 SD of the young adult mean (YAM), age, weight, presence of diabetes mellitus, parathyroid hormone, estimated glomerular filtration rate, prior fracture, back pain, present medications and past medical history. Mean age was 63.7 ± 10.7 years and osteoporosis patients were 41.3 %. The background data of the present participants were almost identical to the subjects participating in the National Health and Nutrition Survey of 2003. Overall, 49.6 % of the subjects had a 25(OH)D value <20 ng/mL and 27.8 % had a 25(OH)D value from 20 to 24 ng/mL. The propensity score for exposure to 25(OH)D < 25 ng/mL in the present and independent community dwelling populations, namely the Miyama and Taiji cohorts, were not significantly different, suggesting no evidence for selection bias. The generalized additive models showed clear decreasing trends in incidence rates of proximal femur and long bone fractures at higher levels of 25(OH)D, and the annual incidence rate of proximal femur fracture was around 0.0005 in women with 25(OH)D > 25 ng/mL, probably leading to the decreasing trend in long bone fracture. Multivariate-adjusted rate ratios of 25(OH)D < 25 ng/mL were 1.01 (95 % confidence interval [CI], 0.84–1.22,
p
= 0.88) for vertebral fracture, 2.71 (95 % CI 0.94–7.83,
p
= 0.07) for proximal femur fracture, and 2.20 (95 % CI 1.37–3.53,
p
< 0.01) for long bone fracture. The respective rate ratios of a BMD level lower than −2.5 SD of the YAM were 1.61 (95 % CI 1.33–1.94,
p
< 0.01), 1.52 (95 % CI 0.67–3.45,
p
= 0.32), and 1.54 (95 % CI 1.02–2.33,
p
= 0.04). In conclusion, 25(OH)D is a leading risk factor for long bone fracture comparable to BMD in Japanese postmenopausal women. The contribution of 25(OH)D to fracture risks is substantial even below 25 ng/mL and is possibly site-specific. We recommend measuring the serum 25(OH)D level in primary care settings.</description><subject>Adult</subject><subject>Aged</subject><subject>Asian Continental Ancestry Group</subject><subject>Bone Density</subject><subject>Confidence Intervals</subject><subject>Female</subject><subject>Fractures, Bone - blood</subject><subject>Fractures, Bone - epidemiology</subject><subject>Fractures, Bone - physiopathology</subject><subject>Humans</subject><subject>Japan - epidemiology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Middle Aged</subject><subject>Nutrition Surveys</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Postmenopause - blood</subject><subject>Risk Factors</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><issn>0914-8779</issn><issn>1435-5604</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkUuO1TAQRS0Eoh8NC2CCLDFhYtrfJB6i5q8nMQDGlj-VR5rEDnZC8xbCnLWwMtykQQgJiYFtle-pa5cuQvcZfcwobc9K3VpJKBOEKk6JuIF2TApFVEPlTbSjmknSta0-QXdKuaCUtaplt9EJl7RhSrId-voW8jphrsiHY8jpy_HzsNhpiPgpdjCmy6p8_xYPZ9MeDwVbnIfyEffWLynjvq4xxQN2KQLuc71dM2Cfptlm60bAS9q0agjZjjhALMNyxNX_tZ1thAJ4TmWZIKbZrqUil6kWd9Gt3o4F7l2fp-j982fvzl-S_ZsXr86f7ImXWi3EMm15CFy0HXCunNOd8kxqG4IWWutGBlcH9cG6NjjNZQDvLPcAXd9BH8QperT5zjl9WqEsZhqKh3GsX0trMUw1TSd4I7r_QanqZNPQij78C71Ia451kJ-UENVPV4ptlM-plAy9mfMw2Xw0jJqreM0Wr6nxmqt4jag9D66dVzdB-N3xK88K8A0oVYoHyH88_U_XH3yGshk</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Tanaka, Shiro</creator><creator>Kuroda, Tatsuhiko</creator><creator>Yamazaki, Yasushi</creator><creator>Shiraki, Yumiko</creator><creator>Yoshimura, Noriko</creator><creator>Shiraki, Masataka</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20140901</creationdate><title>Serum 25-hydroxyvitamin D below 25 ng/mL is a risk factor for long bone fracture comparable to bone mineral density in Japanese postmenopausal women</title><author>Tanaka, Shiro ; Kuroda, Tatsuhiko ; Yamazaki, Yasushi ; Shiraki, Yumiko ; Yoshimura, Noriko ; Shiraki, Masataka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495t-a19a2dd2378e225bb985c149add9399964db061cdab7db924decba2cee8f8efd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Asian Continental Ancestry Group</topic><topic>Bone Density</topic><topic>Confidence Intervals</topic><topic>Female</topic><topic>Fractures, Bone - blood</topic><topic>Fractures, Bone - epidemiology</topic><topic>Fractures, Bone - physiopathology</topic><topic>Humans</topic><topic>Japan - epidemiology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Middle Aged</topic><topic>Nutrition Surveys</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Postmenopause - blood</topic><topic>Risk Factors</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tanaka, Shiro</creatorcontrib><creatorcontrib>Kuroda, Tatsuhiko</creatorcontrib><creatorcontrib>Yamazaki, Yasushi</creatorcontrib><creatorcontrib>Shiraki, Yumiko</creatorcontrib><creatorcontrib>Yoshimura, Noriko</creatorcontrib><creatorcontrib>Shiraki, Masataka</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of bone and mineral metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanaka, Shiro</au><au>Kuroda, Tatsuhiko</au><au>Yamazaki, Yasushi</au><au>Shiraki, Yumiko</au><au>Yoshimura, Noriko</au><au>Shiraki, Masataka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum 25-hydroxyvitamin D below 25 ng/mL is a risk factor for long bone fracture comparable to bone mineral density in Japanese postmenopausal women</atitle><jtitle>Journal of bone and mineral metabolism</jtitle><stitle>J Bone Miner Metab</stitle><addtitle>J Bone Miner Metab</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>32</volume><issue>5</issue><spage>514</spage><epage>523</epage><pages>514-523</pages><issn>0914-8779</issn><eissn>1435-5604</eissn><abstract>There is emergent evidence for divergent associations between 25(OH)D levels and fractures by race and ethnicity, but data on Asian populations are sparse. We investigated this association in a primary care cohort of 1470 postmenopausal Japanese women followed for a mean period of 7.2 years and explored a potential threshold of 25(OH)D. Endpoints were incident vertebral, proximal femur, and long bone fractures. Rate ratios were estimated using multivariate Poisson regression adjusted for lumbar or femur bone mineral density (BMD) less than −2.5 SD of the young adult mean (YAM), age, weight, presence of diabetes mellitus, parathyroid hormone, estimated glomerular filtration rate, prior fracture, back pain, present medications and past medical history. Mean age was 63.7 ± 10.7 years and osteoporosis patients were 41.3 %. The background data of the present participants were almost identical to the subjects participating in the National Health and Nutrition Survey of 2003. Overall, 49.6 % of the subjects had a 25(OH)D value <20 ng/mL and 27.8 % had a 25(OH)D value from 20 to 24 ng/mL. The propensity score for exposure to 25(OH)D < 25 ng/mL in the present and independent community dwelling populations, namely the Miyama and Taiji cohorts, were not significantly different, suggesting no evidence for selection bias. The generalized additive models showed clear decreasing trends in incidence rates of proximal femur and long bone fractures at higher levels of 25(OH)D, and the annual incidence rate of proximal femur fracture was around 0.0005 in women with 25(OH)D > 25 ng/mL, probably leading to the decreasing trend in long bone fracture. Multivariate-adjusted rate ratios of 25(OH)D < 25 ng/mL were 1.01 (95 % confidence interval [CI], 0.84–1.22,
p
= 0.88) for vertebral fracture, 2.71 (95 % CI 0.94–7.83,
p
= 0.07) for proximal femur fracture, and 2.20 (95 % CI 1.37–3.53,
p
< 0.01) for long bone fracture. The respective rate ratios of a BMD level lower than −2.5 SD of the YAM were 1.61 (95 % CI 1.33–1.94,
p
< 0.01), 1.52 (95 % CI 0.67–3.45,
p
= 0.32), and 1.54 (95 % CI 1.02–2.33,
p
= 0.04). In conclusion, 25(OH)D is a leading risk factor for long bone fracture comparable to BMD in Japanese postmenopausal women. The contribution of 25(OH)D to fracture risks is substantial even below 25 ng/mL and is possibly site-specific. We recommend measuring the serum 25(OH)D level in primary care settings.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>24061541</pmid><doi>10.1007/s00774-013-0520-3</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0914-8779 |
| ispartof | Journal of bone and mineral metabolism, 2014-09, Vol.32 (5), p.514-523 |
| issn | 0914-8779 1435-5604 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1566832638 |
| source | MEDLINE; SpringerLink (Online service) |
| subjects | Adult Aged Asian Continental Ancestry Group Bone Density Confidence Intervals Female Fractures, Bone - blood Fractures, Bone - epidemiology Fractures, Bone - physiopathology Humans Japan - epidemiology Medicine Medicine & Public Health Metabolic Diseases Middle Aged Nutrition Surveys Original Article Orthopedics Postmenopause - blood Risk Factors Vitamin D - analogs & derivatives Vitamin D - blood |
| title | Serum 25-hydroxyvitamin D below 25 ng/mL is a risk factor for long bone fracture comparable to bone mineral density in Japanese postmenopausal women |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T17%3A00%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Serum%2025-hydroxyvitamin%20D%20below%2025%C2%A0ng/mL%20is%20a%20risk%20factor%20for%20long%20bone%20fracture%20comparable%20to%20bone%20mineral%20density%20in%20Japanese%20postmenopausal%20women&rft.jtitle=Journal%20of%20bone%20and%20mineral%20metabolism&rft.au=Tanaka,%20Shiro&rft.date=2014-09-01&rft.volume=32&rft.issue=5&rft.spage=514&rft.epage=523&rft.pages=514-523&rft.issn=0914-8779&rft.eissn=1435-5604&rft_id=info:doi/10.1007/s00774-013-0520-3&rft_dat=%3Cproquest_cross%3E1566832638%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1560336389&rft_id=info:pmid/24061541&rfr_iscdi=true |