Next generation modeling in GWAS: comparing different genetic architectures

The continuous advancement in genotyping technology has not been accompanied by the application of innovative statistical methods, such as multi-marker methods (MMM), to unravel genetic associations with complex traits. Although the performance of MMM has been widely explored in a prediction context...

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Veröffentlicht in:	Human genetics 2014-10, Vol.133 (10), p.1235-1253
Hauptverfasser:	López de Maturana, Evangelina, Ibáñez-Escriche, Noelia, González-Recio, Óscar, Marenne, Gaëlle, Mehrban, Hossein, Chanock, Stephen J., Goddard, Michael E., Malats, Núria
Format:	Artikel
Sprache:	eng
Schlagworte:	Accuracy Alleles Bayes Theorem Biomedical and Life Sciences Biomedicine Cancer Case-Control Studies Computer Simulation Decision making Epidemiology Gene Frequency Gene Function Genes, Neoplasm Genome-Wide Association Study - statistics & numerical data Genomes Genotype & phenotype Genotyping Techniques - methods Genotyping Techniques - statistics & numerical data Hispanic Americans - genetics Hispanic Americans - statistics & numerical data Human Genetics Humans Linkage Disequilibrium Medical research Metabolic Diseases Molecular Medicine Original Investigation Polymorphism, Single Nucleotide Population genetics Quantitative genetics Quantitative Trait Loci Urinary Bladder Neoplasms - epidemiology Urinary Bladder Neoplasms - genetics
Online-Zugang:	Volltext
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