Single-strand conformational polymorphism analysis of a common single nucleotide variation in WRAP53 gene, rs2287499, and evaluating its association in relation to breast cancer risk and prognosis among Iranian-Azeri population
The WRAP53 (WD40-encoding RNA antisense to p53) gene encodes an antisense RNA, essential for p53 stabilization and induction upon DNA damage. Single nucleotide polymorphisms (SNPs) in WRAP53 have been associated with risk of cancer, which strengthens the role of WRAP53 in the pathogenesis of human m...
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creator | Sedaie Bonab, Aida Pouladi, Nasser Hosseinpourfeizi, Mohammad Ali Ravanbakhsh Gavgani, Reyhaneh Dehghan, Roghayeh Azarfam, Parvin Montazeri, Vahid Fakhrjou, Ashraf |
description | The
WRAP53
(WD40-encoding RNA antisense to p53) gene encodes an antisense RNA, essential for p53 stabilization and induction upon DNA damage. Single nucleotide polymorphisms (SNPs) in
WRAP53
have been associated with risk of cancer, which strengthens the role of
WRAP53
in the pathogenesis of human malignancies. In fact,
WRAP53
has been considered as a candidate cancer susceptibility gene. Accordingly, we performed a study to examine the association of a frequent genetic variation in
WRAP53
, rs2287499 (C/G), with breast cancer risk and prognosis among Iranian-Azeri population. A case–control association study, including 206 cases and 203 controls from Iranian-Azeri population, was conducted. Genomic DNA was extracted from peripheral blood and tumor samples by salting-out method. SNP genotyping was carried out by polymerase chain reaction-based single-strand conformational polymorphism (PCR-SSCP) technique. The sequence variation of SSCP banding patterns was determined by sequencing. The collected data were analyzed through statistical package for the social sciences software, using Chi-square (
χ
2
) or Fisher’s exact tests, with a significance level of 0.05. No significant differences in the allele and genotype frequencies between cases and controls were detected. Similarly, no significant associations between genotypes and clinicopathological data were observed. Concisely, no significant overall associations between rs2287499 and breast cancer risk and prognosis were detected in the studied population. The rs2287499 SNP is not associated with breast cancer predisposition in Iranian-Azeri women; it also cannot be used as a molecular biomarker to predict breast cancer prognosis in Iranian-Azeri population. |
doi_str_mv | 10.1007/s12032-014-0168-4 |
format | Article |
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WRAP53
(WD40-encoding RNA antisense to p53) gene encodes an antisense RNA, essential for p53 stabilization and induction upon DNA damage. Single nucleotide polymorphisms (SNPs) in
WRAP53
have been associated with risk of cancer, which strengthens the role of
WRAP53
in the pathogenesis of human malignancies. In fact,
WRAP53
has been considered as a candidate cancer susceptibility gene. Accordingly, we performed a study to examine the association of a frequent genetic variation in
WRAP53
, rs2287499 (C/G), with breast cancer risk and prognosis among Iranian-Azeri population. A case–control association study, including 206 cases and 203 controls from Iranian-Azeri population, was conducted. Genomic DNA was extracted from peripheral blood and tumor samples by salting-out method. SNP genotyping was carried out by polymerase chain reaction-based single-strand conformational polymorphism (PCR-SSCP) technique. The sequence variation of SSCP banding patterns was determined by sequencing. The collected data were analyzed through statistical package for the social sciences software, using Chi-square (
χ
2
) or Fisher’s exact tests, with a significance level of 0.05. No significant differences in the allele and genotype frequencies between cases and controls were detected. Similarly, no significant associations between genotypes and clinicopathological data were observed. Concisely, no significant overall associations between rs2287499 and breast cancer risk and prognosis were detected in the studied population. The rs2287499 SNP is not associated with breast cancer predisposition in Iranian-Azeri women; it also cannot be used as a molecular biomarker to predict breast cancer prognosis in Iranian-Azeri population.</description><identifier>ISSN: 1357-0560</identifier><identifier>EISSN: 1559-131X</identifier><identifier>DOI: 10.1007/s12032-014-0168-4</identifier><identifier>PMID: 25134915</identifier><identifier>CODEN: MONCEZ</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor - genetics ; Breast cancer ; Breast Neoplasms - diagnosis ; Breast Neoplasms - epidemiology ; Breast Neoplasms - genetics ; Case-Control Studies ; DNA Mutational Analysis ; Ethnic Groups - genetics ; Female ; Genetic Predisposition to Disease - genetics ; Hematology ; Humans ; Internal Medicine ; Iran - epidemiology ; Medicine ; Medicine & Public Health ; Middle Aged ; Mutation, Missense ; Oncology ; Original Paper ; Pathology ; Polymorphism, Single Nucleotide ; Polymorphism, Single-Stranded Conformational ; Prognosis ; Telomerase - genetics ; Young Adult</subject><ispartof>Medical oncology (Northwood, London, England), 2014-09, Vol.31 (9), p.168-168, Article 168</ispartof><rights>Springer Science+Business Media New York 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-f5dedd1e96c1347303048583abd86577f318f0b5a1199be0d05a64e37324d50d3</citedby><cites>FETCH-LOGICAL-c475t-f5dedd1e96c1347303048583abd86577f318f0b5a1199be0d05a64e37324d50d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12032-014-0168-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12032-014-0168-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25134915$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sedaie Bonab, Aida</creatorcontrib><creatorcontrib>Pouladi, Nasser</creatorcontrib><creatorcontrib>Hosseinpourfeizi, Mohammad Ali</creatorcontrib><creatorcontrib>Ravanbakhsh Gavgani, Reyhaneh</creatorcontrib><creatorcontrib>Dehghan, Roghayeh</creatorcontrib><creatorcontrib>Azarfam, Parvin</creatorcontrib><creatorcontrib>Montazeri, Vahid</creatorcontrib><creatorcontrib>Fakhrjou, Ashraf</creatorcontrib><title>Single-strand conformational polymorphism analysis of a common single nucleotide variation in WRAP53 gene, rs2287499, and evaluating its association in relation to breast cancer risk and prognosis among Iranian-Azeri population</title><title>Medical oncology (Northwood, London, England)</title><addtitle>Med Oncol</addtitle><addtitle>Med Oncol</addtitle><description>The
WRAP53
(WD40-encoding RNA antisense to p53) gene encodes an antisense RNA, essential for p53 stabilization and induction upon DNA damage. Single nucleotide polymorphisms (SNPs) in
WRAP53
have been associated with risk of cancer, which strengthens the role of
WRAP53
in the pathogenesis of human malignancies. In fact,
WRAP53
has been considered as a candidate cancer susceptibility gene. Accordingly, we performed a study to examine the association of a frequent genetic variation in
WRAP53
, rs2287499 (C/G), with breast cancer risk and prognosis among Iranian-Azeri population. A case–control association study, including 206 cases and 203 controls from Iranian-Azeri population, was conducted. Genomic DNA was extracted from peripheral blood and tumor samples by salting-out method. SNP genotyping was carried out by polymerase chain reaction-based single-strand conformational polymorphism (PCR-SSCP) technique. The sequence variation of SSCP banding patterns was determined by sequencing. The collected data were analyzed through statistical package for the social sciences software, using Chi-square (
χ
2
) or Fisher’s exact tests, with a significance level of 0.05. No significant differences in the allele and genotype frequencies between cases and controls were detected. Similarly, no significant associations between genotypes and clinicopathological data were observed. Concisely, no significant overall associations between rs2287499 and breast cancer risk and prognosis were detected in the studied population. The rs2287499 SNP is not associated with breast cancer predisposition in Iranian-Azeri women; it also cannot be used as a molecular biomarker to predict breast cancer prognosis in Iranian-Azeri population.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Breast Neoplasms - epidemiology</subject><subject>Breast Neoplasms - genetics</subject><subject>Case-Control Studies</subject><subject>DNA Mutational Analysis</subject><subject>Ethnic Groups - genetics</subject><subject>Female</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Hematology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Iran - epidemiology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mutation, Missense</subject><subject>Oncology</subject><subject>Original Paper</subject><subject>Pathology</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Polymorphism, Single-Stranded Conformational</subject><subject>Prognosis</subject><subject>Telomerase - genetics</subject><subject>Young Adult</subject><issn>1357-0560</issn><issn>1559-131X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNktuK1TAUhosozjj6AN5IwBsvpppjm15uBh0HBhQP6F1Jm9WasU1qVjuw53V9EdPd8YAgeBESku__10ryZ9ljRp8zSssXyDgVPKdMplHoXN7JjplSVc4E-3w3rYUqc6oKepQ9QLyilDPFq_vZEVdMyIqp4-z7e-f7AXKco_GWtMF3IY5mdsGbgUxh2I8hTl8cjsSknT06JKEjJpHjGDzBg5z4pR0gzM4CuTbRHfTEefLp3e6tEqQHD6ckIue6lFV1StZacG2GJZG-J25GYhBD-1sZYdjWcyBNBIMzaY1vIZLo8OvBYIqh92HtyKRWenKRruCMz3c3EF3qfVo2i4fZvc4MCI9u55Ps46uXH85e55dvzi_Odpd5K0s1552yYC2DqmjT65SCCiq10sI0VheqLDvBdEcbZRirqgaopcoUEkQpuLSKWnGSPdt8U2PfFsC5Hh22MAzGQ1iwZqooNNcV0_-BKllJqlWR0Kd_oVdhiekvDoZUCqH0SrGNamNAjNDVU3Sjifua0XoNS72FpU5hqdew1DJpntw6L80I9pfiZzoSwDcA05HvIf5R-p-uPwBqAczb</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Sedaie Bonab, Aida</creator><creator>Pouladi, Nasser</creator><creator>Hosseinpourfeizi, Mohammad Ali</creator><creator>Ravanbakhsh Gavgani, Reyhaneh</creator><creator>Dehghan, Roghayeh</creator><creator>Azarfam, Parvin</creator><creator>Montazeri, Vahid</creator><creator>Fakhrjou, Ashraf</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20140901</creationdate><title>Single-strand conformational polymorphism analysis of a common single nucleotide variation in WRAP53 gene, rs2287499, and evaluating its association in relation to breast cancer risk and prognosis among Iranian-Azeri population</title><author>Sedaie Bonab, Aida ; Pouladi, Nasser ; Hosseinpourfeizi, Mohammad Ali ; Ravanbakhsh Gavgani, Reyhaneh ; Dehghan, Roghayeh ; Azarfam, Parvin ; Montazeri, Vahid ; Fakhrjou, Ashraf</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-f5dedd1e96c1347303048583abd86577f318f0b5a1199be0d05a64e37324d50d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - diagnosis</topic><topic>Breast Neoplasms - epidemiology</topic><topic>Breast Neoplasms - genetics</topic><topic>Case-Control Studies</topic><topic>DNA Mutational Analysis</topic><topic>Ethnic Groups - genetics</topic><topic>Female</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Hematology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Iran - epidemiology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mutation, Missense</topic><topic>Oncology</topic><topic>Original Paper</topic><topic>Pathology</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Polymorphism, Single-Stranded Conformational</topic><topic>Prognosis</topic><topic>Telomerase - genetics</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sedaie Bonab, Aida</creatorcontrib><creatorcontrib>Pouladi, Nasser</creatorcontrib><creatorcontrib>Hosseinpourfeizi, Mohammad Ali</creatorcontrib><creatorcontrib>Ravanbakhsh Gavgani, Reyhaneh</creatorcontrib><creatorcontrib>Dehghan, Roghayeh</creatorcontrib><creatorcontrib>Azarfam, Parvin</creatorcontrib><creatorcontrib>Montazeri, Vahid</creatorcontrib><creatorcontrib>Fakhrjou, Ashraf</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Medical oncology (Northwood, London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sedaie Bonab, Aida</au><au>Pouladi, Nasser</au><au>Hosseinpourfeizi, Mohammad Ali</au><au>Ravanbakhsh Gavgani, Reyhaneh</au><au>Dehghan, Roghayeh</au><au>Azarfam, Parvin</au><au>Montazeri, Vahid</au><au>Fakhrjou, Ashraf</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Single-strand conformational polymorphism analysis of a common single nucleotide variation in WRAP53 gene, rs2287499, and evaluating its association in relation to breast cancer risk and prognosis among Iranian-Azeri population</atitle><jtitle>Medical oncology (Northwood, London, England)</jtitle><stitle>Med Oncol</stitle><addtitle>Med Oncol</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>31</volume><issue>9</issue><spage>168</spage><epage>168</epage><pages>168-168</pages><artnum>168</artnum><issn>1357-0560</issn><eissn>1559-131X</eissn><coden>MONCEZ</coden><abstract>The
WRAP53
(WD40-encoding RNA antisense to p53) gene encodes an antisense RNA, essential for p53 stabilization and induction upon DNA damage. Single nucleotide polymorphisms (SNPs) in
WRAP53
have been associated with risk of cancer, which strengthens the role of
WRAP53
in the pathogenesis of human malignancies. In fact,
WRAP53
has been considered as a candidate cancer susceptibility gene. Accordingly, we performed a study to examine the association of a frequent genetic variation in
WRAP53
, rs2287499 (C/G), with breast cancer risk and prognosis among Iranian-Azeri population. A case–control association study, including 206 cases and 203 controls from Iranian-Azeri population, was conducted. Genomic DNA was extracted from peripheral blood and tumor samples by salting-out method. SNP genotyping was carried out by polymerase chain reaction-based single-strand conformational polymorphism (PCR-SSCP) technique. The sequence variation of SSCP banding patterns was determined by sequencing. The collected data were analyzed through statistical package for the social sciences software, using Chi-square (
χ
2
) or Fisher’s exact tests, with a significance level of 0.05. No significant differences in the allele and genotype frequencies between cases and controls were detected. Similarly, no significant associations between genotypes and clinicopathological data were observed. Concisely, no significant overall associations between rs2287499 and breast cancer risk and prognosis were detected in the studied population. The rs2287499 SNP is not associated with breast cancer predisposition in Iranian-Azeri women; it also cannot be used as a molecular biomarker to predict breast cancer prognosis in Iranian-Azeri population.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>25134915</pmid><doi>10.1007/s12032-014-0168-4</doi><tpages>1</tpages></addata></record> |
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subjects | Adult Aged Aged, 80 and over Biomarkers, Tumor - genetics Breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - epidemiology Breast Neoplasms - genetics Case-Control Studies DNA Mutational Analysis Ethnic Groups - genetics Female Genetic Predisposition to Disease - genetics Hematology Humans Internal Medicine Iran - epidemiology Medicine Medicine & Public Health Middle Aged Mutation, Missense Oncology Original Paper Pathology Polymorphism, Single Nucleotide Polymorphism, Single-Stranded Conformational Prognosis Telomerase - genetics Young Adult |
title | Single-strand conformational polymorphism analysis of a common single nucleotide variation in WRAP53 gene, rs2287499, and evaluating its association in relation to breast cancer risk and prognosis among Iranian-Azeri population |
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