Heat shock factor 1 is required for migration and invasion of human melanoma in vitro and in vivo
Highlights • HSF1 knockdown led to a reduction in melanoma migration and invasive ability in vitro. • HSF1 was required for invasion and metastasis, as well as tumorigenesis in vivo. • These functions were restored by overexpression of wild-type HSF1 in vitro and in vivo. • These results show that H...
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| Veröffentlicht in: | Cancer letters 2014-11, Vol.354 (2), p.329-335 |
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| container_end_page | 335 |
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| container_issue | 2 |
| container_start_page | 329 |
| container_title | Cancer letters |
| container_volume | 354 |
| creator | Nakamura, Yoshitaka Fujimoto, Mitsuaki Fukushima, Sonoko Nakamura, Akiko Hayashida, Naoki Takii, Ryosuke Takaki, Eiichi Nakai, Akira Muto, Masahiko |
| description | Highlights • HSF1 knockdown led to a reduction in melanoma migration and invasive ability in vitro. • HSF1 was required for invasion and metastasis, as well as tumorigenesis in vivo. • These functions were restored by overexpression of wild-type HSF1 in vitro and in vivo. • These results show that HSF1 is indispensable for melanoma progression and metastasis. • HSF1 could be a promising therapeutic target for melanoma. |
| doi_str_mv | 10.1016/j.canlet.2014.08.029 |
| format | Article |
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| ispartof | Cancer letters, 2014-11, Vol.354 (2), p.329-335 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Carcinogenesis Cell Line, Tumor Cell Movement - physiology DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Knockdown Techniques Heat shock factor 1 (HSF1) Heat Shock Transcription Factors Hematology, Oncology and Palliative Medicine Humans Invasion Male Malignant melanoma Melanoma - metabolism Melanoma - pathology Metastasis Mice Mice, Inbred BALB C Mice, Nude Migration Neoplasm Invasiveness Neoplasm Metastasis RNA, Small Interfering - administration & dosage RNA, Small Interfering - genetics Transcription Factors - deficiency Transcription Factors - genetics Transcription Factors - metabolism Tumor Cells, Cultured |
| title | Heat shock factor 1 is required for migration and invasion of human melanoma in vitro and in vivo |
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