Heat shock factor 1 is required for migration and invasion of human melanoma in vitro and in vivo

Highlights • HSF1 knockdown led to a reduction in melanoma migration and invasive ability in vitro. • HSF1 was required for invasion and metastasis, as well as tumorigenesis in vivo. • These functions were restored by overexpression of wild-type HSF1 in vitro and in vivo. • These results show that H...

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Veröffentlicht in:	Cancer letters 2014-11, Vol.354 (2), p.329-335
Hauptverfasser:	Nakamura, Yoshitaka, Fujimoto, Mitsuaki, Fukushima, Sonoko, Nakamura, Akiko, Hayashida, Naoki, Takii, Ryosuke, Takaki, Eiichi, Nakai, Akira, Muto, Masahiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinogenesis Cell Line, Tumor Cell Movement - physiology DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Knockdown Techniques Heat shock factor 1 (HSF1) Heat Shock Transcription Factors Hematology, Oncology and Palliative Medicine Humans Invasion Male Malignant melanoma Melanoma - metabolism Melanoma - pathology Metastasis Mice Mice, Inbred BALB C Mice, Nude Migration Neoplasm Invasiveness Neoplasm Metastasis RNA, Small Interfering - administration & dosage RNA, Small Interfering - genetics Transcription Factors - deficiency Transcription Factors - genetics Transcription Factors - metabolism Tumor Cells, Cultured
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Zusammenfassung:	Highlights • HSF1 knockdown led to a reduction in melanoma migration and invasive ability in vitro. • HSF1 was required for invasion and metastasis, as well as tumorigenesis in vivo. • These functions were restored by overexpression of wild-type HSF1 in vitro and in vivo. • These results show that HSF1 is indispensable for melanoma progression and metastasis. • HSF1 could be a promising therapeutic target for melanoma.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2014.08.029