Pathophysiology of brain dysfunction in hyperammonemic syndromes: The many faces of glutamine

Ineffective hepatic clearance of excess ammonia in the form of urea, as occurs in urea cycle enzymopathies (UCDs) and in liver failure, leads to increases in circulating and tissue concentrations of glutamine and a positive correlation between brain glutamine and the severity of neurological symptom...

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Veröffentlicht in:	Molecular genetics and metabolism 2014-09, Vol.113 (1-2), p.113-117
1. Verfasser:	Butterworth, Roger F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer type 2 astrocytosis Amino Acid Transport System X-AG - metabolism Ammonia Brain Diseases - etiology Brain Diseases - metabolism Brain edema Glutamates - metabolism Glutaminase - metabolism Glutamine Glutamine - metabolism Hepatic encephalopathy Humans Hyperammonemia - complications Mitochondria - metabolism Neurons - metabolism Syndrome Urea cycle enzymopathies
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