Gene expression, function, and diversity of Nkx2-4 in the rainbow trout, Oncorhynchus mykiss

Highlights • We provide the first evidence for Nkx2-4 mRNAs in vertebrate thyroid follicles. • Three types of Nkx2-4 mRNAs (a–c) were found in the rainbow trout thyroid. • Nkx2-4a and Nkx2-4b directly transactivated thyroglobulin gene expression. • Nkx2-4c did not show a significant increase in the...

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Veröffentlicht in:	General and comparative endocrinology 2014-09, Vol.206, p.193-202
Hauptverfasser:	Uemae, Youji, Sakamoto, Joe, Hidaka, Yoshie, Hiratsuka, Ai, Susa, Takao, Kato, Yukio, Suzuki, Masakazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Cloning, Molecular DNA, Complementary - genetics Electrophoretic Mobility Shift Assay Endocrinology & Metabolism Gene Expression Regulation In Situ Hybridization Molecular Sequence Data Nkx2-1 Nkx2-4 Nuclear Proteins - genetics Nuclear Proteins - metabolism Oncorhynchus mykiss - metabolism Ovary Phylogeny Protein Isoforms - metabolism Rainbow trout RNA, Messenger - metabolism Sequence Homology, Amino Acid Thyroglobulin - metabolism Thyroid Nuclear Factor 1 Thyroid transcription factor Tissue Distribution Transcription Factors - genetics Transcription Factors - metabolism Transcriptional Activation TTF-1
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Zusammenfassung:	Highlights • We provide the first evidence for Nkx2-4 mRNAs in vertebrate thyroid follicles. • Three types of Nkx2-4 mRNAs (a–c) were found in the rainbow trout thyroid. • Nkx2-4a and Nkx2-4b directly transactivated thyroglobulin gene expression. • Nkx2-4c did not show a significant increase in the thyroglobulin expression. • The results are important for understanding gene regulation in the fish thyroid.
ISSN:	0016-6480 1095-6840
DOI:	10.1016/j.ygcen.2014.07.007