Quercetin Prevents Unloading-Derived Disused Muscle Atrophy by Attenuating the Induction of Ubiquitin Ligases in Tail-Suspension Mice
The effects of quercetin (1) were investigated on disused muscle atrophy using mice that underwent tail suspension. Periodic injection of 1 into the gastrocnemius muscle suppressed muscle weight loss and ubiquitin ligase expression. Compound 1 reduced the enhancement of lipid peroxidation in the mus...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2010-10, Vol.73 (10), p.1708-1710 |
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| container_issue | 10 |
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| container_title | Journal of natural products (Washington, D.C.) |
| container_volume | 73 |
| creator | Mukai, Rie Nakao, Reiko Yamamoto, Hironori Nikawa, Takeshi Takeda, Eiji Terao, Junji |
| description | The effects of quercetin (1) were investigated on disused muscle atrophy using mice that underwent tail suspension. Periodic injection of 1 into the gastrocnemius muscle suppressed muscle weight loss and ubiquitin ligase expression. Compound 1 reduced the enhancement of lipid peroxidation in the muscle. Injection of N-acetyl-l-cysteine, but not flavone (2), also prevented muscle weight loss and enhancement of lipid peroxidation. These findings demonstrate that 1 can prevent disused muscle atrophy by attenuating the expression of ubiquitin ligases and that such prevention originates from its antioxidant activity. |
| doi_str_mv | 10.1021/np100240y |
| format | Article |
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Periodic injection of 1 into the gastrocnemius muscle suppressed muscle weight loss and ubiquitin ligase expression. Compound 1 reduced the enhancement of lipid peroxidation in the muscle. Injection of N-acetyl-l-cysteine, but not flavone (2), also prevented muscle weight loss and enhancement of lipid peroxidation. These findings demonstrate that 1 can prevent disused muscle atrophy by attenuating the expression of ubiquitin ligases and that such prevention originates from its antioxidant activity.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np100240y</identifier><identifier>PMID: 20853873</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Northbrook, IL: American Chemical Society and American Society of Pharmacognosy</publisher><subject>Acetylcysteine - pharmacology ; Animals ; Antioxidants - pharmacology ; Biological and medical sciences ; Flavones - chemistry ; Flavones - pharmacology ; Hindlimb Suspension ; Lipid Peroxidation - drug effects ; Male ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Molecular Structure ; Muscle ; Muscle, Skeletal - drug effects ; Muscular Atrophy - drug therapy ; Pharmacology. Drug treatments ; Polymerase Chain Reaction ; Propane - analogs & derivatives ; Propane - pharmacology ; Quercetin - chemistry ; Quercetin - pharmacology ; Thiobarbituric Acid Reactive Substances - analysis ; Ubiquitin-Protein Ligases - drug effects</subject><ispartof>Journal of natural products (Washington, D.C.), 2010-10, Vol.73 (10), p.1708-1710</ispartof><rights>Copyright © 2010 American Chemical Society and American Society of Pharmacognosy and American Society of Pharmacognosy</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a411t-2c7925950de991572e4f9d133ff72efa8bc787dd3708a6c8a179ba4aa045614a3</citedby><cites>FETCH-LOGICAL-a411t-2c7925950de991572e4f9d133ff72efa8bc787dd3708a6c8a179ba4aa045614a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/np100240y$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/np100240y$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23347414$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20853873$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mukai, Rie</creatorcontrib><creatorcontrib>Nakao, Reiko</creatorcontrib><creatorcontrib>Yamamoto, Hironori</creatorcontrib><creatorcontrib>Nikawa, Takeshi</creatorcontrib><creatorcontrib>Takeda, Eiji</creatorcontrib><creatorcontrib>Terao, Junji</creatorcontrib><title>Quercetin Prevents Unloading-Derived Disused Muscle Atrophy by Attenuating the Induction of Ubiquitin Ligases in Tail-Suspension Mice</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>The effects of quercetin (1) were investigated on disused muscle atrophy using mice that underwent tail suspension. Periodic injection of 1 into the gastrocnemius muscle suppressed muscle weight loss and ubiquitin ligase expression. Compound 1 reduced the enhancement of lipid peroxidation in the muscle. Injection of N-acetyl-l-cysteine, but not flavone (2), also prevented muscle weight loss and enhancement of lipid peroxidation. These findings demonstrate that 1 can prevent disused muscle atrophy by attenuating the expression of ubiquitin ligases and that such prevention originates from its antioxidant activity.</description><subject>Acetylcysteine - pharmacology</subject><subject>Animals</subject><subject>Antioxidants - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Flavones - chemistry</subject><subject>Flavones - pharmacology</subject><subject>Hindlimb Suspension</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Molecular Structure</subject><subject>Muscle</subject><subject>Muscle, Skeletal - drug effects</subject><subject>Muscular Atrophy - drug therapy</subject><subject>Pharmacology. Drug treatments</subject><subject>Polymerase Chain Reaction</subject><subject>Propane - analogs & derivatives</subject><subject>Propane - pharmacology</subject><subject>Quercetin - chemistry</subject><subject>Quercetin - pharmacology</subject><subject>Thiobarbituric Acid Reactive Substances - analysis</subject><subject>Ubiquitin-Protein Ligases - drug effects</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0Mtu1DAUBmALgehQWPACyBskWAR8zWVZtVwqTQWIzjo6cU6mrjJO6hNXmgfgvfGoQ7thdf7F59_Sz9hbKT5JoeTnMEshlBH7Z2wlrRJFKZR9zlZClrrQdWlO2CuiWyGEFo19yU6UqK2uK71if34ljA4XH_jPiPcYFuKbME7Q-7AtLjD6e-z5hadE-V4lciPysyVO882ed_scFwwJ8vstX26QX4Y-ucVPgU8D33T-LvlD99pvgZB4jtfgx-J3ohkDHdyVd_iavRhgJHxzvKds8_XL9fn3Yv3j2-X52boAI-VSKFc1yjZW9Ng00lYKzdD0UuthyHmAunNVXfW9rkQNpatBVk0HBkAYW0oD-pR9eOid43SXkJZ258nhOELAKVErbVnWSqnKZPrxgbo4EUUc2jn6HcR9K0V7WL19XD3bd8fa1O2wf5T_Zs7g_REAORiHCMF5enJam8pI8-TAUXs7pRjyGv_58C_TDZdR</recordid><startdate>20101022</startdate><enddate>20101022</enddate><creator>Mukai, Rie</creator><creator>Nakao, Reiko</creator><creator>Yamamoto, Hironori</creator><creator>Nikawa, Takeshi</creator><creator>Takeda, Eiji</creator><creator>Terao, Junji</creator><general>American Chemical Society and American Society of Pharmacognosy</general><general>American Society of Pharmacognosy</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20101022</creationdate><title>Quercetin Prevents Unloading-Derived Disused Muscle Atrophy by Attenuating the Induction of Ubiquitin Ligases in Tail-Suspension Mice</title><author>Mukai, Rie ; Nakao, Reiko ; Yamamoto, Hironori ; Nikawa, Takeshi ; Takeda, Eiji ; Terao, Junji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a411t-2c7925950de991572e4f9d133ff72efa8bc787dd3708a6c8a179ba4aa045614a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Acetylcysteine - pharmacology</topic><topic>Animals</topic><topic>Antioxidants - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Flavones - chemistry</topic><topic>Flavones - pharmacology</topic><topic>Hindlimb Suspension</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Molecular Structure</topic><topic>Muscle</topic><topic>Muscle, Skeletal - drug effects</topic><topic>Muscular Atrophy - drug therapy</topic><topic>Pharmacology. Drug treatments</topic><topic>Polymerase Chain Reaction</topic><topic>Propane - analogs & derivatives</topic><topic>Propane - pharmacology</topic><topic>Quercetin - chemistry</topic><topic>Quercetin - pharmacology</topic><topic>Thiobarbituric Acid Reactive Substances - analysis</topic><topic>Ubiquitin-Protein Ligases - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mukai, Rie</creatorcontrib><creatorcontrib>Nakao, Reiko</creatorcontrib><creatorcontrib>Yamamoto, Hironori</creatorcontrib><creatorcontrib>Nikawa, Takeshi</creatorcontrib><creatorcontrib>Takeda, Eiji</creatorcontrib><creatorcontrib>Terao, Junji</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mukai, Rie</au><au>Nakao, Reiko</au><au>Yamamoto, Hironori</au><au>Nikawa, Takeshi</au><au>Takeda, Eiji</au><au>Terao, Junji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quercetin Prevents Unloading-Derived Disused Muscle Atrophy by Attenuating the Induction of Ubiquitin Ligases in Tail-Suspension Mice</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>2010-10-22</date><risdate>2010</risdate><volume>73</volume><issue>10</issue><spage>1708</spage><epage>1710</epage><pages>1708-1710</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><coden>JNPRDF</coden><abstract>The effects of quercetin (1) were investigated on disused muscle atrophy using mice that underwent tail suspension. Periodic injection of 1 into the gastrocnemius muscle suppressed muscle weight loss and ubiquitin ligase expression. Compound 1 reduced the enhancement of lipid peroxidation in the muscle. Injection of N-acetyl-l-cysteine, but not flavone (2), also prevented muscle weight loss and enhancement of lipid peroxidation. These findings demonstrate that 1 can prevent disused muscle atrophy by attenuating the expression of ubiquitin ligases and that such prevention originates from its antioxidant activity.</abstract><cop>Northbrook, IL</cop><pub>American Chemical Society and American Society of Pharmacognosy</pub><pmid>20853873</pmid><doi>10.1021/np100240y</doi><tpages>3</tpages></addata></record> |
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| subjects | Acetylcysteine - pharmacology Animals Antioxidants - pharmacology Biological and medical sciences Flavones - chemistry Flavones - pharmacology Hindlimb Suspension Lipid Peroxidation - drug effects Male Medical sciences Mice Mice, Inbred C57BL Molecular Structure Muscle Muscle, Skeletal - drug effects Muscular Atrophy - drug therapy Pharmacology. Drug treatments Polymerase Chain Reaction Propane - analogs & derivatives Propane - pharmacology Quercetin - chemistry Quercetin - pharmacology Thiobarbituric Acid Reactive Substances - analysis Ubiquitin-Protein Ligases - drug effects |
| title | Quercetin Prevents Unloading-Derived Disused Muscle Atrophy by Attenuating the Induction of Ubiquitin Ligases in Tail-Suspension Mice |
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