Importance of the Two Interferon-stimulated Response Element (ISRE) Sequences in the Regulation of the Human Indoleamine 2,3-Dioxygenase Gene

Indoleamine 2,3-dioxygenase (INDO) is the rate-limiting enzyme in the catabolism of the essential amino acid L -tryptophan. It is induced strongly in many cell lines following interferon-γ treatment. We report the cloning and characterization of the full-length human INDO promoter. This promoter is...

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Veröffentlicht in:	The Journal of biological chemistry 1996-08, Vol.271 (32), p.19140-19145
Hauptverfasser:	Konan, K V, Taylor, M W
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Chloramphenicol O-Acetyltransferase - genetics Cloning, Molecular DNA, Complementary Gene Expression Regulation, Enzymologic - genetics Humans Interferon-gamma - pharmacology Molecular Sequence Data Mutagenesis, Site-Directed Promoter Regions, Genetic Sequence Deletion Tryptophan Oxygenase - genetics Tumor Cells, Cultured
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