Effect of AST on age-associated changes of vocal folds in a rat model

Objectives/Hypothesis Reactive oxygen species (ROS) are associated with aging. Astaxanthin (AST) is a strong antioxidant and has been reported to prevent various ROS‐induced diseases. In the current study, we investigated the effect of AST on age‐associated histological and mRNA changes of vocal fol...

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Veröffentlicht in:	The Laryngoscope 2014-10, Vol.124 (10), p.E411-E417
Hauptverfasser:	Mizuta, Masanobu, Hirano, Shigeru, Hiwatashi, Nao, Kobayashi, Toshiki, Tateya, Ichiro, Kanemaru, Shin-ichi, Nakamura, Tatsuo, Ito, Juichi
Format:	Artikel
Sprache:	eng
Schlagworte:	age-associated changes Aging - drug effects Aging - metabolism Aldehydes - metabolism Animals Antioxidants Antioxidants - pharmacology AST Chromatography, High Pressure Liquid Disease Models, Animal Fibrinolytic Agents Fibroblast Growth Factor 2 - biosynthesis Fibroblast Growth Factor 2 - genetics Follow-Up Studies Gene Expression Regulation Hepatocyte Growth Factor - biosynthesis Hepatocyte Growth Factor - genetics Immunohistochemistry Male Oxidative Stress Prospective Studies Rats Rats, Sprague-Dawley reactive oxygen species Reactive Oxygen Species - metabolism Real-Time Polymerase Chain Reaction RNA, Messenger - genetics Rodents Vocal Cord Dysfunction - genetics Vocal Cord Dysfunction - metabolism Vocal Cord Dysfunction - prevention & control Vocal Cords - drug effects Vocal Cords - metabolism Vocal Cords - pathology vocal folds Xanthophylls - pharmacology
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