Role of Rho small GTPases in meniscus cells

ABSTRACT We previously reported that mechanical stretch regulates Sry‐type HMG box (SOX) 9‐dependent α1(II) collagen (COL2A1) expression in inner meniscus cells. This study examined the role of the small Rho guanosine 5' triphosphatase Rac1 and Rho‐associated kinase (ROCK) in the regulation of...

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Veröffentlicht in:	Journal of orthopaedic research 2014-11, Vol.32 (11), p.1479-1486
Hauptverfasser:	Kanazawa, Tomoko, Furumatsu, Takayuki, Matsumoto-Ogawa, Emi, Maehara, Ami, Ozaki, Toshifumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Animals Arthroplasty, Replacement, Knee Biomechanical Phenomena Cartilage - enzymology Collagen Type II - metabolism CREB Cyclic AMP Response Element-Binding Protein - metabolism Gene Expression Regulation, Enzymologic Humans Knee - physiology Mechanical stretch Meniscus Phosphorylation Promoter Regions, Genetic Rac1 rac1 GTP-Binding Protein - metabolism Rats rho GTP-Binding Proteins - metabolism ROCK SOX9 SOX9 Transcription Factor - metabolism Stress, Mechanical Tensile Strength
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