Prevalence and Predictors of Vitamin D Deficiency and Response to Oral Supplementation in Patients Receiving Long-Term Home Parenteral Nutrition
Previous studies have suggested a high prevalence of vitamin D deficiency in patients receiving long-term home parenteral nutrition (HPN). The aim of this study was to determine the prevalence and predictors of vitamin D deficiency in long-term HPN patients. Methods: A retrospective, institutional r...
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| Veröffentlicht in: | Nutrition in clinical practice 2014-10, Vol.29 (5), p.681-685 |
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| creator | Bharadwaj, Shishira Gohel, Tushar D. Deen, Omer J. Coughlin, Kathleen L. Corrigan, Mandy L. Fisher, Jill Lopez, Rocio Shatnawei, Abdullah Kirby, Donald F. |
| description | Previous studies have suggested a high prevalence of vitamin D deficiency in patients receiving long-term home parenteral nutrition (HPN). The aim of this study was to determine the prevalence and predictors of vitamin D deficiency in long-term HPN patients. Methods: A retrospective, institutional review board–approved study was performed on all adult patients followed by the Cleveland Clinic HPN program receiving HPN therapy >6 months between 1989 and 2013 with a 25-(OH) D3 level reported. Patients were categorized by serum vitamin D status as follows: sufficient, insufficient, and deficient with respective 25-(OH) D3 levels of ≥30 ng/mL, 20–30 ng/mL, and |
| doi_str_mv | 10.1177/0884533614539178 |
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The aim of this study was to determine the prevalence and predictors of vitamin D deficiency in long-term HPN patients. Methods: A retrospective, institutional review board–approved study was performed on all adult patients followed by the Cleveland Clinic HPN program receiving HPN therapy >6 months between 1989 and 2013 with a 25-(OH) D3 level reported. Patients were categorized by serum vitamin D status as follows: sufficient, insufficient, and deficient with respective 25-(OH) D3 levels of ≥30 ng/mL, 20–30 ng/mL, and <20 ng/mL. Results: Seventy-nine patients were categorized based on serum vitamin D status as follows: 35 (44.3%) deficient, 24 (30.4%) insufficient, and 20 (25.3%) sufficient. The mean age of the cohort at the initiation of HPN was 52.0 ± 12.7 years, and 26 (32.9%) were male. The median HPN duration was 39 months, and the most common indication was inflammatory bowel disease (36.7%). Most (82.3%) patients had at least 1 prescription of oral vitamin D supplement (50,000 International Units) during this time. History of jejunal resection (odds ratio [OR], 5.3; 95% confidence interval [CI], 1.9–15.1; P = .002) and lack of oral vitamin D supplementation (OR, 0.7; 95% CI, 0.52–0.93; P = .038) were the strongest predictors of vitamin D deficiency. Conclusion: Vitamin D deficiency is common among patients receiving long-term HPN despite oral supplementation.</description><identifier>ISSN: 0884-5336</identifier><identifier>EISSN: 1941-2452</identifier><identifier>DOI: 10.1177/0884533614539178</identifier><identifier>PMID: 25038058</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adult ; avitaminosis ; Dietary Supplements ; Female ; home parenteral nutrition ; Humans ; Inflammatory Bowel Diseases - therapy ; Jejunum - surgery ; Male ; Middle Aged ; Nursing ; Parenteral Nutrition, Home Total - adverse effects ; Prevalence ; Retrospective Studies ; total parenteral nutrition ; vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamin D - therapeutic use ; vitamin D deficiency ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - drug therapy ; Vitamin D Deficiency - epidemiology ; Vitamin D Deficiency - etiology ; Vitamins - blood ; Vitamins - therapeutic use</subject><ispartof>Nutrition in clinical practice, 2014-10, Vol.29 (5), p.681-685</ispartof><rights>2014 American Society for Parenteral and Enteral Nutrition</rights><rights>2014 by The American Society for Parenteral and Enteral Nutrition</rights><rights>2014 American Society for Parenteral and Enteral Nutrition.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3831-3995f48ae9a450171fe881e6e52b4a6360a8193c86fceab367c8cf869d21a7333</citedby><cites>FETCH-LOGICAL-c3831-3995f48ae9a450171fe881e6e52b4a6360a8193c86fceab367c8cf869d21a7333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1177%2F0884533614539178$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1177%2F0884533614539178$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25038058$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bharadwaj, Shishira</creatorcontrib><creatorcontrib>Gohel, Tushar D.</creatorcontrib><creatorcontrib>Deen, Omer J.</creatorcontrib><creatorcontrib>Coughlin, Kathleen L.</creatorcontrib><creatorcontrib>Corrigan, Mandy L.</creatorcontrib><creatorcontrib>Fisher, Jill</creatorcontrib><creatorcontrib>Lopez, Rocio</creatorcontrib><creatorcontrib>Shatnawei, Abdullah</creatorcontrib><creatorcontrib>Kirby, Donald F.</creatorcontrib><title>Prevalence and Predictors of Vitamin D Deficiency and Response to Oral Supplementation in Patients Receiving Long-Term Home Parenteral Nutrition</title><title>Nutrition in clinical practice</title><addtitle>Nutr Clin Pract</addtitle><description>Previous studies have suggested a high prevalence of vitamin D deficiency in patients receiving long-term home parenteral nutrition (HPN). The aim of this study was to determine the prevalence and predictors of vitamin D deficiency in long-term HPN patients. Methods: A retrospective, institutional review board–approved study was performed on all adult patients followed by the Cleveland Clinic HPN program receiving HPN therapy >6 months between 1989 and 2013 with a 25-(OH) D3 level reported. Patients were categorized by serum vitamin D status as follows: sufficient, insufficient, and deficient with respective 25-(OH) D3 levels of ≥30 ng/mL, 20–30 ng/mL, and <20 ng/mL. Results: Seventy-nine patients were categorized based on serum vitamin D status as follows: 35 (44.3%) deficient, 24 (30.4%) insufficient, and 20 (25.3%) sufficient. The mean age of the cohort at the initiation of HPN was 52.0 ± 12.7 years, and 26 (32.9%) were male. The median HPN duration was 39 months, and the most common indication was inflammatory bowel disease (36.7%). Most (82.3%) patients had at least 1 prescription of oral vitamin D supplement (50,000 International Units) during this time. History of jejunal resection (odds ratio [OR], 5.3; 95% confidence interval [CI], 1.9–15.1; P = .002) and lack of oral vitamin D supplementation (OR, 0.7; 95% CI, 0.52–0.93; P = .038) were the strongest predictors of vitamin D deficiency. Conclusion: Vitamin D deficiency is common among patients receiving long-term HPN despite oral supplementation.</description><subject>Adult</subject><subject>avitaminosis</subject><subject>Dietary Supplements</subject><subject>Female</subject><subject>home parenteral nutrition</subject><subject>Humans</subject><subject>Inflammatory Bowel Diseases - therapy</subject><subject>Jejunum - surgery</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nursing</subject><subject>Parenteral Nutrition, Home Total - adverse effects</subject><subject>Prevalence</subject><subject>Retrospective Studies</subject><subject>total parenteral nutrition</subject><subject>vitamin D</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>Vitamin D - therapeutic use</subject><subject>vitamin D deficiency</subject><subject>Vitamin D Deficiency - blood</subject><subject>Vitamin D Deficiency - drug therapy</subject><subject>Vitamin D Deficiency - epidemiology</subject><subject>Vitamin D Deficiency - etiology</subject><subject>Vitamins - blood</subject><subject>Vitamins - therapeutic use</subject><issn>0884-5336</issn><issn>1941-2452</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhq0K1C4t954qH7kEPHHs2MdqWyjSql3RwjXyeicrV4md2knRvgWPjMMWDkiIi-3RfN8va4aQc2DvAer6A1OqEpxLyKeGWh2RBegKirIS5SuymNvF3D8hb1J6ZAwUr9UxOSkF44oJtSA_1hGfTYfeIjV-S3O5dXYMMdHQ0m9uNL3z9IpeYeusy9j-F_YF0xB8QjoGehdNR--nYeiwRz-a0QVPs7TOr1ynDFt0z87v6Cr4XfGAsac3ocdMxAzg7N9OY3SzeUZet6ZL-PblPiVfP14_LG-K1d2nz8vLVWG54lBwrUVbKYPaVIJBDS0qBShRlJvKSC6ZUaC5VbK1aDZc1lbZVkm9LcHUnPNT8u6QO8TwNGEam94li11nPIYpNSCkBABd64yyA2pjSCli2wzR9SbuG2DNvIfm7z1k5eIlfdr0uP0j_B58BsQB-O463P83sLldrplUkL3i4CWzw-YxTNHnKf37Iz8BakKgSw</recordid><startdate>201410</startdate><enddate>201410</enddate><creator>Bharadwaj, Shishira</creator><creator>Gohel, Tushar D.</creator><creator>Deen, Omer J.</creator><creator>Coughlin, Kathleen L.</creator><creator>Corrigan, Mandy L.</creator><creator>Fisher, Jill</creator><creator>Lopez, Rocio</creator><creator>Shatnawei, Abdullah</creator><creator>Kirby, Donald F.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201410</creationdate><title>Prevalence and Predictors of Vitamin D Deficiency and Response to Oral Supplementation in Patients Receiving Long-Term Home Parenteral Nutrition</title><author>Bharadwaj, Shishira ; Gohel, Tushar D. ; Deen, Omer J. ; Coughlin, Kathleen L. ; Corrigan, Mandy L. ; Fisher, Jill ; Lopez, Rocio ; Shatnawei, Abdullah ; Kirby, Donald F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3831-3995f48ae9a450171fe881e6e52b4a6360a8193c86fceab367c8cf869d21a7333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>avitaminosis</topic><topic>Dietary Supplements</topic><topic>Female</topic><topic>home parenteral nutrition</topic><topic>Humans</topic><topic>Inflammatory Bowel Diseases - therapy</topic><topic>Jejunum - surgery</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nursing</topic><topic>Parenteral Nutrition, Home Total - adverse effects</topic><topic>Prevalence</topic><topic>Retrospective Studies</topic><topic>total parenteral nutrition</topic><topic>vitamin D</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>Vitamin D - therapeutic use</topic><topic>vitamin D deficiency</topic><topic>Vitamin D Deficiency - blood</topic><topic>Vitamin D Deficiency - drug therapy</topic><topic>Vitamin D Deficiency - epidemiology</topic><topic>Vitamin D Deficiency - etiology</topic><topic>Vitamins - blood</topic><topic>Vitamins - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bharadwaj, Shishira</creatorcontrib><creatorcontrib>Gohel, Tushar D.</creatorcontrib><creatorcontrib>Deen, Omer J.</creatorcontrib><creatorcontrib>Coughlin, Kathleen L.</creatorcontrib><creatorcontrib>Corrigan, Mandy L.</creatorcontrib><creatorcontrib>Fisher, Jill</creatorcontrib><creatorcontrib>Lopez, Rocio</creatorcontrib><creatorcontrib>Shatnawei, Abdullah</creatorcontrib><creatorcontrib>Kirby, Donald F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition in clinical practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bharadwaj, Shishira</au><au>Gohel, Tushar D.</au><au>Deen, Omer J.</au><au>Coughlin, Kathleen L.</au><au>Corrigan, Mandy L.</au><au>Fisher, Jill</au><au>Lopez, Rocio</au><au>Shatnawei, Abdullah</au><au>Kirby, Donald F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and Predictors of Vitamin D Deficiency and Response to Oral Supplementation in Patients Receiving Long-Term Home Parenteral Nutrition</atitle><jtitle>Nutrition in clinical practice</jtitle><addtitle>Nutr Clin Pract</addtitle><date>2014-10</date><risdate>2014</risdate><volume>29</volume><issue>5</issue><spage>681</spage><epage>685</epage><pages>681-685</pages><issn>0884-5336</issn><eissn>1941-2452</eissn><abstract>Previous studies have suggested a high prevalence of vitamin D deficiency in patients receiving long-term home parenteral nutrition (HPN). The aim of this study was to determine the prevalence and predictors of vitamin D deficiency in long-term HPN patients. Methods: A retrospective, institutional review board–approved study was performed on all adult patients followed by the Cleveland Clinic HPN program receiving HPN therapy >6 months between 1989 and 2013 with a 25-(OH) D3 level reported. Patients were categorized by serum vitamin D status as follows: sufficient, insufficient, and deficient with respective 25-(OH) D3 levels of ≥30 ng/mL, 20–30 ng/mL, and <20 ng/mL. Results: Seventy-nine patients were categorized based on serum vitamin D status as follows: 35 (44.3%) deficient, 24 (30.4%) insufficient, and 20 (25.3%) sufficient. The mean age of the cohort at the initiation of HPN was 52.0 ± 12.7 years, and 26 (32.9%) were male. The median HPN duration was 39 months, and the most common indication was inflammatory bowel disease (36.7%). Most (82.3%) patients had at least 1 prescription of oral vitamin D supplement (50,000 International Units) during this time. History of jejunal resection (odds ratio [OR], 5.3; 95% confidence interval [CI], 1.9–15.1; P = .002) and lack of oral vitamin D supplementation (OR, 0.7; 95% CI, 0.52–0.93; P = .038) were the strongest predictors of vitamin D deficiency. Conclusion: Vitamin D deficiency is common among patients receiving long-term HPN despite oral supplementation.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>25038058</pmid><doi>10.1177/0884533614539178</doi><tpages>5</tpages></addata></record> |
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| ispartof | Nutrition in clinical practice, 2014-10, Vol.29 (5), p.681-685 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Adult avitaminosis Dietary Supplements Female home parenteral nutrition Humans Inflammatory Bowel Diseases - therapy Jejunum - surgery Male Middle Aged Nursing Parenteral Nutrition, Home Total - adverse effects Prevalence Retrospective Studies total parenteral nutrition vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D - therapeutic use vitamin D deficiency Vitamin D Deficiency - blood Vitamin D Deficiency - drug therapy Vitamin D Deficiency - epidemiology Vitamin D Deficiency - etiology Vitamins - blood Vitamins - therapeutic use |
| title | Prevalence and Predictors of Vitamin D Deficiency and Response to Oral Supplementation in Patients Receiving Long-Term Home Parenteral Nutrition |
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