Safety and efficacy of sonographically guided high-intensity focused ultrasound for symptomatic uterine fibroids: preliminary study of a modified protocol
We aimed to assess the safety and efficacy of sonographically guided high-intensity focused ultrasound for treating patients with symptomatic uterine fibroids using a modified protocol. This work was part of an ongoing prospective phase 1 study. Twenty patients with 22 symptomatic fibroids were trea...
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| Veröffentlicht in: | Journal of ultrasound in medicine 2014-10, Vol.33 (10), p.1811-1818 |
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| container_title | Journal of ultrasound in medicine |
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| creator | Leung, Joyce H Y Yu, Simon C H Cheung, Eva C W Wong, Alyssa S W Tong, Mabel M B Ho, Stella S Y Leung, Vivian Y F Ahuja, Anil T |
| description | We aimed to assess the safety and efficacy of sonographically guided high-intensity focused ultrasound for treating patients with symptomatic uterine fibroids using a modified protocol.
This work was part of an ongoing prospective phase 1 study. Twenty patients with 22 symptomatic fibroids were treated with sonographically guided high-intensity focused ultrasound under no anesthesia. The modified protocol consisted of repeated and shortened ( |
| doi_str_mv | 10.7863/ultra.33.10.1811 |
| format | Article |
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This work was part of an ongoing prospective phase 1 study. Twenty patients with 22 symptomatic fibroids were treated with sonographically guided high-intensity focused ultrasound under no anesthesia. The modified protocol consisted of repeated and shortened (<25 minutes) treatment sessions of high-input acoustic intensity (1000-1500 W/cm(2)) and intensified sonication pulses (1500-2000) at each spot. The primary end points were periprocedural complications. The secondary end points were symptomatic improvement and radiologic evidence of treatment responses, including the degree of fibroid infarction and volume shrinkage 3 months after treatment. Symptomatic improvement was assessed by a pain score, a pictorial chart menstrual score, the Urogenital Distress Inventory short form, and the Incontinence Impact Questionnaire short form. The degree of fibroid infarction was assessed by the nonperfused ratio on contrast-enhanced magnetic resonance imaging, defined as the ratio of the nonperfused fibroid volume to the total fibroid volume.
Nineteen patients tolerated the treatment well, with no major adverse events. One patient who received treatment for a fibroid located within 6 cm from the skin had third-degree skin burns at 2 sites of 1 cm in diameter. Fibroid-related abdominal pain, pictorial chart, Urogenital Distress Inventory, and Incontinence Impact Questionnaire scores were significantly improved (P < .05). The median nonperfused ratio at 3 months was 20% (95% confidence interval, 5%-32.5%). Median volume shrinkage at 3 months was 17.2% (95% confidence interval, 4.3%-26.6%).
Sonographically guided high-intensity focused ultrasound using a modified protocol may be safe and effective for symptomatic uterine fibroids in selected patients to avoid skin burns.</description><identifier>ISSN: 0278-4297</identifier><identifier>EISSN: 1550-9613</identifier><identifier>DOI: 10.7863/ultra.33.10.1811</identifier><identifier>PMID: 25253828</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Contrast Media - administration & dosage ; Female ; High-Intensity Focused Ultrasound Ablation - adverse effects ; High-Intensity Focused Ultrasound Ablation - methods ; Humans ; Leiomyoma - pathology ; Leiomyoma - surgery ; Magnetic Resonance Imaging ; Meglumine - administration & dosage ; Middle Aged ; Organometallic Compounds - administration & dosage ; Pain Measurement ; Prospective Studies ; Surveys and Questionnaires ; Time Factors ; Treatment Outcome ; Ultrasonography, Interventional ; Uterine Neoplasms - pathology ; Uterine Neoplasms - surgery</subject><ispartof>Journal of ultrasound in medicine, 2014-10, Vol.33 (10), p.1811-1818</ispartof><rights>2014 by the American Institute of Ultrasound in Medicine.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c252t-543cc47fe11f598e052324b18cae2b92249a0676d6b77ebc191530325b9764163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25253828$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leung, Joyce H Y</creatorcontrib><creatorcontrib>Yu, Simon C H</creatorcontrib><creatorcontrib>Cheung, Eva C W</creatorcontrib><creatorcontrib>Wong, Alyssa S W</creatorcontrib><creatorcontrib>Tong, Mabel M B</creatorcontrib><creatorcontrib>Ho, Stella S Y</creatorcontrib><creatorcontrib>Leung, Vivian Y F</creatorcontrib><creatorcontrib>Ahuja, Anil T</creatorcontrib><title>Safety and efficacy of sonographically guided high-intensity focused ultrasound for symptomatic uterine fibroids: preliminary study of a modified protocol</title><title>Journal of ultrasound in medicine</title><addtitle>J Ultrasound Med</addtitle><description>We aimed to assess the safety and efficacy of sonographically guided high-intensity focused ultrasound for treating patients with symptomatic uterine fibroids using a modified protocol.
This work was part of an ongoing prospective phase 1 study. Twenty patients with 22 symptomatic fibroids were treated with sonographically guided high-intensity focused ultrasound under no anesthesia. The modified protocol consisted of repeated and shortened (<25 minutes) treatment sessions of high-input acoustic intensity (1000-1500 W/cm(2)) and intensified sonication pulses (1500-2000) at each spot. The primary end points were periprocedural complications. The secondary end points were symptomatic improvement and radiologic evidence of treatment responses, including the degree of fibroid infarction and volume shrinkage 3 months after treatment. Symptomatic improvement was assessed by a pain score, a pictorial chart menstrual score, the Urogenital Distress Inventory short form, and the Incontinence Impact Questionnaire short form. The degree of fibroid infarction was assessed by the nonperfused ratio on contrast-enhanced magnetic resonance imaging, defined as the ratio of the nonperfused fibroid volume to the total fibroid volume.
Nineteen patients tolerated the treatment well, with no major adverse events. One patient who received treatment for a fibroid located within 6 cm from the skin had third-degree skin burns at 2 sites of 1 cm in diameter. Fibroid-related abdominal pain, pictorial chart, Urogenital Distress Inventory, and Incontinence Impact Questionnaire scores were significantly improved (P < .05). The median nonperfused ratio at 3 months was 20% (95% confidence interval, 5%-32.5%). Median volume shrinkage at 3 months was 17.2% (95% confidence interval, 4.3%-26.6%).
Sonographically guided high-intensity focused ultrasound using a modified protocol may be safe and effective for symptomatic uterine fibroids in selected patients to avoid skin burns.</description><subject>Adult</subject><subject>Contrast Media - administration & dosage</subject><subject>Female</subject><subject>High-Intensity Focused Ultrasound Ablation - adverse effects</subject><subject>High-Intensity Focused Ultrasound Ablation - methods</subject><subject>Humans</subject><subject>Leiomyoma - pathology</subject><subject>Leiomyoma - surgery</subject><subject>Magnetic Resonance Imaging</subject><subject>Meglumine - administration & dosage</subject><subject>Middle Aged</subject><subject>Organometallic Compounds - administration & dosage</subject><subject>Pain Measurement</subject><subject>Prospective Studies</subject><subject>Surveys and Questionnaires</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Ultrasonography, Interventional</subject><subject>Uterine Neoplasms - pathology</subject><subject>Uterine Neoplasms - surgery</subject><issn>0278-4297</issn><issn>1550-9613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UcuO1DAQtBCIHRbunJCPXDK47dhOuKEVL2klDsA5cpz2jFESBz8O-RW-Fs_swqmlUldVVxchr4EddafEuzLnaI5CHCsAHcATcgApWdMrEE_JgXHdNS3v9Q15kdIvxjgD3T4nN1xyKTreHcif78Zh3qlZJ4rOeWvsToOjKazhFM12rsg87_RU_IQTPfvTufFrxjX5ynLBllTh6x0plCriQqRpX7YcFpO9pSVj9CtS58cY_JTe0y3i7Be_mrjTlMt09TN0CZN3voptMeRgw_ySPHNmTvjqcd6Sn58-_rj70tx_-_z17sN9Y2uM3MhWWNtqhwBO9h0yyQVvR-isQT72nLe9YUqrSY1a42ihBymY4HLstWpBiVvy9kG3Gv8umPKw-GRxns2KoaQBpFIATPVtXWUPqzaGlCK6YYt-qUEGYMOlkeH6iUGIC3BppFLePKqXccHpP-FfBeIvM3aLyg</recordid><startdate>201410</startdate><enddate>201410</enddate><creator>Leung, Joyce H Y</creator><creator>Yu, Simon C H</creator><creator>Cheung, Eva C W</creator><creator>Wong, Alyssa S W</creator><creator>Tong, Mabel M B</creator><creator>Ho, Stella S Y</creator><creator>Leung, Vivian Y F</creator><creator>Ahuja, Anil T</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201410</creationdate><title>Safety and efficacy of sonographically guided high-intensity focused ultrasound for symptomatic uterine fibroids: preliminary study of a modified protocol</title><author>Leung, Joyce H Y ; Yu, Simon C H ; Cheung, Eva C W ; Wong, Alyssa S W ; Tong, Mabel M B ; Ho, Stella S Y ; Leung, Vivian Y F ; Ahuja, Anil T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c252t-543cc47fe11f598e052324b18cae2b92249a0676d6b77ebc191530325b9764163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Contrast Media - administration & dosage</topic><topic>Female</topic><topic>High-Intensity Focused Ultrasound Ablation - adverse effects</topic><topic>High-Intensity Focused Ultrasound Ablation - methods</topic><topic>Humans</topic><topic>Leiomyoma - pathology</topic><topic>Leiomyoma - surgery</topic><topic>Magnetic Resonance Imaging</topic><topic>Meglumine - administration & dosage</topic><topic>Middle Aged</topic><topic>Organometallic Compounds - administration & dosage</topic><topic>Pain Measurement</topic><topic>Prospective Studies</topic><topic>Surveys and Questionnaires</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Ultrasonography, Interventional</topic><topic>Uterine Neoplasms - pathology</topic><topic>Uterine Neoplasms - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leung, Joyce H Y</creatorcontrib><creatorcontrib>Yu, Simon C H</creatorcontrib><creatorcontrib>Cheung, Eva C W</creatorcontrib><creatorcontrib>Wong, Alyssa S W</creatorcontrib><creatorcontrib>Tong, Mabel M B</creatorcontrib><creatorcontrib>Ho, Stella S Y</creatorcontrib><creatorcontrib>Leung, Vivian Y F</creatorcontrib><creatorcontrib>Ahuja, Anil T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ultrasound in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leung, Joyce H Y</au><au>Yu, Simon C H</au><au>Cheung, Eva C W</au><au>Wong, Alyssa S W</au><au>Tong, Mabel M B</au><au>Ho, Stella S Y</au><au>Leung, Vivian Y F</au><au>Ahuja, Anil T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Safety and efficacy of sonographically guided high-intensity focused ultrasound for symptomatic uterine fibroids: preliminary study of a modified protocol</atitle><jtitle>Journal of ultrasound in medicine</jtitle><addtitle>J Ultrasound Med</addtitle><date>2014-10</date><risdate>2014</risdate><volume>33</volume><issue>10</issue><spage>1811</spage><epage>1818</epage><pages>1811-1818</pages><issn>0278-4297</issn><eissn>1550-9613</eissn><abstract>We aimed to assess the safety and efficacy of sonographically guided high-intensity focused ultrasound for treating patients with symptomatic uterine fibroids using a modified protocol.
This work was part of an ongoing prospective phase 1 study. Twenty patients with 22 symptomatic fibroids were treated with sonographically guided high-intensity focused ultrasound under no anesthesia. The modified protocol consisted of repeated and shortened (<25 minutes) treatment sessions of high-input acoustic intensity (1000-1500 W/cm(2)) and intensified sonication pulses (1500-2000) at each spot. The primary end points were periprocedural complications. The secondary end points were symptomatic improvement and radiologic evidence of treatment responses, including the degree of fibroid infarction and volume shrinkage 3 months after treatment. Symptomatic improvement was assessed by a pain score, a pictorial chart menstrual score, the Urogenital Distress Inventory short form, and the Incontinence Impact Questionnaire short form. The degree of fibroid infarction was assessed by the nonperfused ratio on contrast-enhanced magnetic resonance imaging, defined as the ratio of the nonperfused fibroid volume to the total fibroid volume.
Nineteen patients tolerated the treatment well, with no major adverse events. One patient who received treatment for a fibroid located within 6 cm from the skin had third-degree skin burns at 2 sites of 1 cm in diameter. Fibroid-related abdominal pain, pictorial chart, Urogenital Distress Inventory, and Incontinence Impact Questionnaire scores were significantly improved (P < .05). The median nonperfused ratio at 3 months was 20% (95% confidence interval, 5%-32.5%). Median volume shrinkage at 3 months was 17.2% (95% confidence interval, 4.3%-26.6%).
Sonographically guided high-intensity focused ultrasound using a modified protocol may be safe and effective for symptomatic uterine fibroids in selected patients to avoid skin burns.</abstract><cop>England</cop><pmid>25253828</pmid><doi>10.7863/ultra.33.10.1811</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Contrast Media - administration & dosage Female High-Intensity Focused Ultrasound Ablation - adverse effects High-Intensity Focused Ultrasound Ablation - methods Humans Leiomyoma - pathology Leiomyoma - surgery Magnetic Resonance Imaging Meglumine - administration & dosage Middle Aged Organometallic Compounds - administration & dosage Pain Measurement Prospective Studies Surveys and Questionnaires Time Factors Treatment Outcome Ultrasonography, Interventional Uterine Neoplasms - pathology Uterine Neoplasms - surgery |
| title | Safety and efficacy of sonographically guided high-intensity focused ultrasound for symptomatic uterine fibroids: preliminary study of a modified protocol |
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